Journal of Autism and Developmental Disorders

, Volume 45, Issue 5, pp 1176–1190

Cortical Variability in the Sensory-Evoked Response in Autism

  • Sarah M. Haigh
  • David J. Heeger
  • Ilan Dinstein
  • Nancy Minshew
  • Marlene Behrmann
Original Paper

DOI: 10.1007/s10803-014-2276-6

Cite this article as:
Haigh, S.M., Heeger, D.J., Dinstein, I. et al. J Autism Dev Disord (2015) 45: 1176. doi:10.1007/s10803-014-2276-6

Abstract

Previous findings have shown that individuals with autism spectrum disorder (ASD) evince greater intra-individual variability (IIV) in their sensory-evoked fMRI responses compared to typical control participants. We explore the robustness of this finding with a new sample of high-functioning adults with autism. Participants were presented with visual, somatosensory and auditory stimuli in the scanner whilst they completed a one-back task. While ASD and control participants were statistically indistinguishable with respect to behavioral responses, the new ASD group exhibited greater IIV relative to controls. We also show that the IIV was equivalent across hemispheres and remained stable over the duration of the experiment. This suggests that greater cortical IIV may be a replicable characteristic of sensory systems in autism.

Keywords

Autism fMRI Sensory-evoked Variability 

Supplementary material

10803_2014_2276_MOESM1_ESM.doc (412 kb)
Supplementary material 1 (DOC 412 kb)

Copyright information

© Springer Science+Business Media New York 2014

Authors and Affiliations

  • Sarah M. Haigh
    • 1
    • 6
  • David J. Heeger
    • 2
  • Ilan Dinstein
    • 3
  • Nancy Minshew
    • 4
    • 5
  • Marlene Behrmann
    • 1
  1. 1.Department of PsychologyCarnegie Mellon UniversityPittsburghUSA
  2. 2.Department of Psychology and Center for Neural ScienceNew York UniversityNew YorkUSA
  3. 3.Psychology DepartmentBen-Gurion University of the Negev, 653Beer-ShebaIsrael
  4. 4.Department of PsychiatryUniversity of PittsburghPittsburghUSA
  5. 5.Department of NeurologyUniversity of PittsburghPittsburghUSA
  6. 6.Department of PsychiatryUniversity of PittsburghPittsburghUSA

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