Journal of Autism and Developmental Disorders

, Volume 44, Issue 7, pp 1546–1555 | Cite as

Maternal Immune-Mediated Conditions, Autism Spectrum Disorders, and Developmental Delay

  • Kristen Lyall
  • Paul Ashwood
  • Judy Van de Water
  • Irva Hertz-Picciotto
Original Paper


The maternal immune system may play a role in offspring neurodevelopment. We examined whether maternal autoimmune disease, asthma, and allergy were associated with child autism spectrum disorder (ASD) and developmental delay without autism (DD) using 560 ASD cases, 391 typically developing controls, and 168 DD cases from the CHildhood Autism Risk from Genetics and the Environment (CHARGE) study. Results from conditional logistic regression demonstrated few significant associations overall. Maternal autoimmune disease was significantly associated with a modest increase in odds of developmental disorders (combined ASD + DD; OR = 1.46, 95 % CI 1.01, 2.09) but not of ASD alone. Associations with certain allergens and onset periods were also suggested. These findings suggest maternal autoimmune disease may modestly influence childhood developmental disorders (ASD + DD).


Autoimmune disease Asthma Allergy Autism Developmental delay Maternal risk factors 



This work was supported by the following grants: National Institute of Environmental Health Sciences R01 ES015359, National Institute of Environmental Health Sciences P01 ES11269, Environmental Protection Agency STAR #R829388 & R833292, and 5-T32MH073124. The authors have no financial relationships relevant to this article or conflicts of interest to disclose.

Supplementary material

10803_2013_2017_MOESM1_ESM.doc (42 kb)
Supplementary material 1 (DOC 42 kb)


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Kristen Lyall
    • 1
  • Paul Ashwood
    • 2
  • Judy Van de Water
    • 2
  • Irva Hertz-Picciotto
    • 1
    • 2
  1. 1.Department of Public Health SciencesUniveristy of CaliforniaDavisUSA
  2. 2.MIND InstituteUniversity of California, Davis SacramentoUSA

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