Journal of Autism and Developmental Disorders

, Volume 44, Issue 3, pp 521–531 | Cite as

Nasal Oxytocin for Social Deficits in Childhood Autism: A Randomized Controlled Trial

  • Mark R. DaddsEmail author
  • Elayne MacDonald
  • Avril Cauchi
  • Katrina Williams
  • Florence Levy
  • John Brennan
Original Paper


The last two decades have witnessed a surge in research investigating the application of oxytocin as a method of enhancing social behaviour in humans. Preliminary evidence suggests oxytocin may have potential as an intervention for autism. We evaluated a 5-day ‘live-in’ intervention using a double-blind randomized control trial. 38 male youths (7–16 years old) with autism spectrum disorders were administered 24 or 12 international units (depending on weight) intranasal placebo or oxytocin once daily over four consecutive days. The oxytocin or placebo was administered during parent–child interaction training sessions. Parent and child behaviours were assessed using parent reports, clinician ratings, and independent observations, at multiple time points to measure side-effects; social interaction skills; repetitive behaviours; emotion recognition and diagnostic status. Compared to placebo, intranasal oxytocin did not significantly improve emotion recognition, social interaction skills, or general behavioral adjustment in male youths with autism spectrum disorders. The results show that the benefits of nasal oxytocin for young individuals with autism spectrum disorders may be more circumscribed than suggested by previous studies, and suggest caution in recommending it as an intervention that is broadly effective.


Autism Oxytocin Children Randomized controlled trial 



Funding for this research was supported by project Grant #568694 from the National Health and Medical Research Council of Australia to the first author. The authors wish to thank Royal Far West and the participating families for their support.

Conflict of interest

The authors report no financial interests or potential conflicts of interest.

Supplementary material

10803_2013_1899_MOESM1_ESM.docx (24 kb)
Supplementary material 1 (DOCX 24 kb)


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Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Mark R. Dadds
    • 1
    Email author
  • Elayne MacDonald
    • 1
  • Avril Cauchi
    • 1
  • Katrina Williams
    • 2
  • Florence Levy
    • 3
  • John Brennan
    • 3
  1. 1.School of PsychologyUniversity of New South WalesSydneyAustralia
  2. 2.Murdoch Children’s Research InstituteUniversity of MelbourneMelbourneAustralia
  3. 3.School of PsychiatryUniversity of New South WalesSydneyAustralia

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