An Electrophysiological Investigation of Interhemispheric Transfer Time in Children and Adolescents with High-Functioning Autism Spectrum Disorders
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Little is known about the functional impact of putative deficits in white-matter connectivity across the corpus callosum (CC) in individuals with autism spectrum disorders (ASDs). We utilized the temporal sensitivity of event-related potentials to examine the interhemispheric transfer time (IHTT) of basic visual information across the CC in youth with high-functioning ASD relative to healthy controls. We conducted two experiments: a visual letter matching experiment (n = 46) and a visual picture matching experiment, (n = 48) and utilized both electrophysiological (N1 and P1 amplitudes and latencies) and behavioral [response times (RTs), error rates] indices of IHTT. There were no significant group differences on either experiment for RTs, error rates, or N1 and P1 latencies, suggesting that on basic tasks the timing of information flow across the CC may not be altered in high functioning ASD.
KeywordsAutism Interhemispheric transfer time N1 P1 Event-related potential Corpus callosum White matter
We gratefully acknowledge the assistance of Kyle Jamison, Whitney Worsham, Whitney Ernst, and Tiffany Newton in data collection. This study was supported by funds from the Brigham Young University College of Family, Home, and Social Sciences, and the Poelman Foundation.
Conflict of interest
The authors report no conflicts of interest.
- Barnea-Goraly, N., Lotspeich, L. J., & Reiss, A. L. (2010). Similar white matter aberrations in children with autism and their unaffected siblings: A diffusion tensor imaging study using tract-based spatial statistics. Archives of General Psychiatry, 67, 1052–1060. doi: 10.1001/archgenpsychiatry.2010.123.PubMedCrossRefGoogle Scholar
- Birmaher, B., Brent, D. A., Chiappetta, L., Bridge, J., Monga, S., & Baugher, M. (1999). Psychometric properties of the screen for child anxiety related emotional disorders (SCARED): A replication study. Journal of the American Academy of Child and Adolescent Psychiatry, 38, 1230–1236.PubMedCrossRefGoogle Scholar
- Dien, J., & Santuzzi, A. M. (2005). Principal components analysis of event-related potential datasets. In T. Handy (Ed.), Event-related potentials: A methods handbook. Cambridge: MIT Press.Google Scholar
- Fabri, M., Polonara, G., Del Pesce, M., Quattrini, A., Salvolini, U., & Manzoni, T. (2001). Posterior corpus callosum and interhemispheric transfer of somatosensory information: An fMRI and neuropsychological study of a partially callosotomized patient. Journal of Cognitive Neuroscience, 13, 1071–1079. doi: 10.1162/089892901753294365.PubMedCrossRefGoogle Scholar
- Hong, S., Ke, X., Tang, T., Hang, Y., Chu, K., Huang, H., et al. (2011). Detecting abnormalities of corpus callosum connectivity in autism using magnetic resonance imaging and diffusion tensor tractography. Psychiatry Research: Neuroimaging, 194, 333–339. doi: 10.1016/j.pscychresns.2011.03.009.PubMedCrossRefGoogle Scholar
- Just, M. A., Cherkassky, V. L., Keller, T. A., Kana, R. K., & Minshew, N. J. (2007). Functional and anatomical cortical underconnectivity in autism: Evidence from an fMRI study of an executive function task and corpus callosum morphometry. Cerebral Cortex, 17, 951–961. doi: 10.1093/cercor/bhl006.PubMedCrossRefGoogle Scholar
- Levin, H. S., Wilde, E. A., Chu, Z., Yallampalli, R., Hanten, G. R., & Li, X. (2008). Diffusion tensor imaging in relation to cognitive and functional outcome of traumatic brain injury in children. The Journal of Head Trauma Rehabilitation, 23, 197–208. doi: 10.1097/01.HTR.0000327252.54128.7c.PubMedCentralPubMedCrossRefGoogle Scholar
- Lo, Y., Soong, W., Gau, S. S., Wu, Y., Lai, M., Yeh, F., et al. (2011). The loss of asymmetry and reduced interhemispheric connectivity in adolescents with autism: A study using diffusion spectrum imaging tractography. Psychiatry Research: Neuroimaging, 192, 60–66. doi: 10.1016/j.pscychresns.2010.09.008.PubMedCrossRefGoogle Scholar
- Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.PubMedCrossRefGoogle Scholar
- Pfefferbaum, A., Sullivan, E. V., Hedehus, M., Adalsteinsson, E., Lim, K. O., & Moseley, M. (2000). In vivo detection and functional correlates of white matter microstructural disruption in chronic alcoholism. Alcoholism, Clinical and Experimental Research, 24, 1214–1221. doi: 10.1111/j.1530-0277.2000.tb02086.x.PubMedCrossRefGoogle Scholar
- Shukla, D. K., Keehn, B., Lincoln, A. J., & Müller, R. A. (2010). White matter compromise of callosal and subcortical fiber tracts in children with autism spectrum disorder: A diffusion tensor imaging study. Journal of the American Academy of Child and Adolescent Psychiatry, 49(1269–1278), e1262. doi: 10.1016/j.jaac.2010.08.018.Google Scholar
- Yamauchi, H., Fukuyama, H., Nagahama, Y., Katsumi, Y., Dong, Y., Konishi, J., et al. (1996). Atrophy of the corpus callosum associated with cognitive impairment and widespread cortical hypometabolism in carotid artery occlusive disease. Archives of Neurology, 53, 1103–1109.PubMedCrossRefGoogle Scholar