Parent-Reported Gastro-intestinal Symptoms in Children with Autism Spectrum Disorders
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The objective of this study is to investigate whether parentally-reported gastro-intestinal (GI) symptoms are increased in a population-derived sample of children with autism spectrum disorders (ASD) compared to controls. Participants included 132 children with ASD and 81 with special educational needs (SEN) but no ASD, aged 10–14 years plus 82 typically developing (TD) children. Data were collected on GI symptoms, diet, cognitive abilities, and developmental histories. Nearly half (weighted rate 46.5 %) of children with ASD had at least one individual lifetime GI symptom compared with 21.8 % of TD children and 29.2 % of those with SEN. Children with ASD had more past and current GI symptoms than TD or SEN groups although fewer current symptoms were reported in all groups compared with the past. The ASD group had significantly increased past vomiting and diarrhoea compared with the TD group and more abdominal pain than the SEN group. The ASD group had more current constipation (when defined as bowel movement less than three times per week) and soiling than either the TD or SEN groups. No association was found between GI symptoms and intellectual ability, ASD severity, ASD regression or limited or faddy diet. Parents report more GI symptoms in children with ASD than children with either SEN or TD children but the frequency of reported symptoms is greater in the past than currently in all groups.
KeywordsAutism Autism spectrum disorders Gastro-intestinal symptoms Dietary intake Regression
We would like to thank the parents and children who participated. We would also like to thank the anonymous reviewers. The study was funded by the Department of Health, the Wellcome Trust and the National Alliance for Autism Research (NAAR).
South Thames MREC 00/1/50; Kent & Medway LREC WK153/8/02.
- Dunn, L. M., Dunn, L. M., Whetton, C., & Burley, J. (1997). British picture vocabulary scale (2nd ed.). London: NFER-Nelson.Google Scholar
- Lord, C., Risi, S., Lambrecht, L., Cook, E. H., Leventhal, B. L., DiLavore, P. C., et al. (2000). The autism diagnostic observation schedule-generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30(3), 205–223.PubMedCrossRefGoogle Scholar
- Raven, J. C., Court, J. H., & Raven, J. (1990a). Standard progressive matrices. Oxford: Oxford University Press.Google Scholar
- Raven, J. C., Court, J. H., & Raven, J. (1990b). Coloured progressive matrices. Oxford: Oxford University Press.Google Scholar
- Richler, J., Luyster, R., Risi, S., Dawson, G., Bernier, R., Dunn, M., et al. (2006). Is there a ‘regressive phenotype’ of autism spectrum disorder associated with the measles-mumps-rubella vaccine? A CPEA study. Journal of Autism and Developmental Disorders, 36(3), 299–316.PubMedCrossRefGoogle Scholar
- Rome III (2006) Diagnostic criteria of functional gastro-intestinal disorders. www.romecriteria.org/criteria.
- Rutter, M., Bailey, A., & Lord, C. (2003). SCQ: The Social Communication Questionnaire. Manual. Los Angeles: Western Psychological Services.Google Scholar
- Simonoff, E., Pickles, A., Charman, T., Chandler, S., Loucas, T., & Baird, G. (2008). Psychiatric disorders in children with autism spectrum disorders: Prevalence, comorbidity, and associated factors in a population-derived sample. Journal of the American Academy of Child and Adolescent Psychiatry, 47(8), 921–929.PubMedCrossRefGoogle Scholar
- Stata Corporation. (2005). Stata statistical software release 9.0: Survey data manual. College Station, TX: Stata Corporation.Google Scholar
- Valicenti-McDermott, M., McVicar, K., Rapin, I., Wershil, B. K., Cohen, H., & Shinnar, S. (2006). Frequency of gastrointestinal symptoms in children with autistic spectrum disorders and association with family history of autoimmune disease. Journal of Developmental and Behavioral Pediatrics, 27(2 Suppl), S128–S136.PubMedCrossRefGoogle Scholar
- Wang, L. W., Tancredi, D. J., & Thomas, D. W. (2011). The prevalence of gastrointestinal problems in children across the United States with autism spectrum disorders from families with multiple affected members. Journal of Developmental and Behavioral Pediatrics, 32(5), 351–360.PubMedCrossRefGoogle Scholar
- Wechsler, D. (1992). Wechsler intelligence scale for children (III-UK edition). London: The Psychological Corporation.Google Scholar