Journal of Autism and Developmental Disorders

, Volume 43, Issue 9, pp 2207–2210 | Cite as

Brief Report: Childhood Disintegrative Disorder as a Likely Manifestation of Vitamin B12 Deficiency

  • Savita Malhotra
  • B. N. Subodh
  • Preeti Parakh
  • Sanjay Lahariya
Brief Report

Abstract

Childhood disintegrative disorder is a rare disorder, characterized by regression of acquired skills after a period of normal development. The case of childhood disintegrative disorder presented here was found to have vitamin B12 deficiency and hyperhomocysteinemia on extensive evaluation to find a probable cause for regression. This case illustrates the need for a thorough evaluation of all cases of childhood disintegrative disorder so that treatable causes of regression, like vitamin B12 deficiency, are not missed.

Keywords

Childhood disintegrative disorder Autism Vitamin B12 deficiency Hyperhomocysteinemia 

References

  1. Bertoglio, K., James, S. J., Deprey, L., Brule, N., & Hendren, R. (2010). Pilot study of the effect of methyl B12 treatment on behavioural and biomarker measures in children with autism. Journal of Alternative and Complementary Medicine, 16, 555–560.CrossRefGoogle Scholar
  2. Chauhan, A., & Chauhan, V. (2006). Oxidative stress in autism. Pathophysiology, 13, 171–181.PubMedCrossRefGoogle Scholar
  3. Frombonne, E. (2009). Epidemiology of pervasive developmental disorders. Pediatric Research, 65, 591–598.CrossRefGoogle Scholar
  4. Heller, T. (1908). Dementia infantilis. Zeitschrift fur die Erforschung und Behandlung des Jugenlichen Schwachsinns, 2, 141–165.Google Scholar
  5. Hendry, C. N. (2000). Childhood disintegrative disorder: Should it be considered a distinct diagnosis? Clinical Psychology Review, 20(1), 77–90.PubMedCrossRefGoogle Scholar
  6. James, S. J., Cutler, P., Melnyk, S., Jernigan, S., Janak, L., Gaylor, D. W., et al. (2004). Metabolic biomarkers of increased oxidative stress and impaired methylation capacity in children with autism. American Journal of Clinical Nutrition, 80, 1611–1617.PubMedGoogle Scholar
  7. Malhotra, S., & Gupta, N. (1999). Childhood disintegrative disorder. Journal of Autism and Developmental Disorders, 29, 491–498.PubMedCrossRefGoogle Scholar
  8. Malhotra, S., & Gupta, N. (2002). Childhood disintegrative disorder: Re-examination of the current concept. European Child and Adolescent Psychiatry, 11, 108–114.PubMedCrossRefGoogle Scholar
  9. Pineles, S. L., Avery, R. A., & Liu, G. T. (2010). Vitamin B12 optic neuropathy in autism. Pediatrics, 126, e967–e970.PubMedCrossRefGoogle Scholar
  10. Volkmar, F. R., Klin, A., Marans, W., & Cohen, D. J. (1997). Childhood disintegrative disorder. In D. J. Cohen & F. R. Volkmar (Eds.), Handbook of autism and pervasive developmental disorders (2nd ed., pp. 47–58). New York: Wiley.Google Scholar
  11. Werder, S. F. (2010). Cobalamin deficiency, hyperhomocysteinemia, and dementia. Neuropsychiatric Disease and Treatment, 6, 159–195.PubMedCrossRefGoogle Scholar
  12. Yao, Y., Walsh, W. J., McGinnis, W. R., & Praticò, D. (2006). Altered vascular phenotype in autism: Correlation with oxidative stress. Archives of Neurology, 63, 1161–1164.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media New York 2013

Authors and Affiliations

  • Savita Malhotra
    • 1
  • B. N. Subodh
    • 1
  • Preeti Parakh
    • 1
  • Sanjay Lahariya
    • 1
  1. 1.Department of PsychiatryPostgraduate Institute of Medical Education and ResearchChandigarhIndia

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