Divergent Patterns of Social Cognition Performance in Autism and 22q11.2 Deletion Syndrome (22q11DS)
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Individuals with developmental disorders frequently report a range of social cognition deficits including difficulties identifying facial displays of emotion. This study examined the specificity of face emotion processing deficits in adolescents with either autism or 22q11DS compared to typically developing (TD) controls. Two tasks (face emotion recognition and weather scene recognition) were used to explore group differences in visual scanpath strategy and concurrent recognition accuracy. For faces, the autism and 22q11DS groups demonstrated lower emotion recognition accuracy and fewer fixations compared to the TD group. Individuals with autism demonstrated fewer fixations to some weather scene stimuli compared to 22q11DS and TD groups, yet achieved a level of recognition accuracy comparable to the TD group. These findings provide evidence for a divergent pattern of social cognition dysfunction in autism and 22q11DS.
KeywordsAutism Velo-cardio-facial syndrome (VCFS) Face processing Visual information processing
We would like to thank Dr. Kathryn Leadbeater and Ms. Brooke Sinderberry for their assistance in recruitment for the current study. Funding for the current study was obtained from the Hunter Medical Research Institute (HMRI) in the form of a Port-Waratah Coal Services post-doctoral fellowship and from the National Health and Medical Research Council (NMMRC) in the form of an Australian Training Fellowship (455624). The study was supported by the Schizophrenia Research Institute utilising infrastructure funding from the NSW Ministry of Health and funding from NSW Trade and Investment.
Conflict of interest
The authors declare that they have no conflict of interest.
- American Psychiatric Association. (2000). Task force on dsm-iv: Dsm-iv-tr. Diagnostic and statistical manual of mental disorders. Washington, DC: American Psychiatric Association.Google Scholar
- Fine, S. E., Weissman, A., Gerdes, M., Pinto-Martin, J., Zackai, E. H., McDonald-McGinn, D. M., et al. (2005). Autism spectrum disorders and symptoms in children with molecularly confirmed 22q11.2 deletion syndrome. Journal of Autism and Developmental Disorders, 35(4), 461–470.PubMedCrossRefGoogle Scholar
- First, M. B., Spitzer, R. L., Gibbon, M., & Williams, J. B. W. (2002). Structured clinical interview for dsm-iv-tr axis i disorders, research version, patient edition with psychotic screen (scid-i/p w/psy screen) New York, Biometrics Research.Google Scholar
- Goldenberg, P. C., Calkins, M. E., Richard, J., McDonald-McGinn, D., Zackai, E., Mitra, N., et al. (2012). Computerized neurocognitive profile in young people with 22q11.2 deletion syndrome compared to youths with schizophrenia and at-risk for psychosis. American Journal of Medical Genetics. Pt B, Neuropsychiatric Genetics: the Official Publication of the International Society of Psychiatric Genetics, 159B(1), 87–93.CrossRefGoogle Scholar
- Kates, W. R., Antshel, K. M., Fremont, W. P., Shprintzen, R. J., Strunge, L. A., Burnette, C. P., et al. (2007). Comparing phenotypes in patients with idiopathic autism to patients with velocardiofacial syndrome (22q11DS) with and without autism. American Journal of Medical Genetics. Pt A. 143A(22), 2642–2650.Google Scholar
- Kaufman, J., Birmaher, B., Brent, D., Rao, U., Flynn, C., Moreci, P., et al. (1997). Schedule for affective disorders and schizophrenia for school-age children-present and lifetime version (K-SADS-PL): Initial reliability and validity data. Journal of the American Academy of Child and Adolescent Psychiatry, 36(7), 980–988.PubMedCrossRefGoogle Scholar
- Kuhlthau, K., Orlich, F., Hall, T. A., Sikora, D., Kovacs, E. A., Delahaye, J., et al. (2010). Health-related quality of life in children with autism spectrum disorders: Results from the autism treatment network. Journal of Autism and Developmental Disorders, 40(6), 721–729.PubMedCrossRefGoogle Scholar
- Vorstman, J. A., Staal, W. G., van Daalen, E., van Engeland, H., Hochstenbach, P. F. and Franke, L. (2006). Identification of novel autism candidate regions through analysis of reported cytogenetic abnormalities associated with autism. Molecular Psychiatry 11(1), 1, 18–28.Google Scholar
- Wechsler, D. (1999). Wechsler abbreviated scale of intelligence. San Antonio, TX: The Psychological Corporation.Google Scholar