Journal of Autism and Developmental Disorders

, Volume 43, Issue 7, pp 1623–1629 | Cite as

Bone Density in Peripubertal Boys with Autism Spectrum Disorders

  • Ann M. Neumeyer
  • Amy Gates
  • Christine Ferrone
  • Hang Lee
  • Madhusmita Misra
Original Paper

Abstract

We determined whether bone mineral density (BMD) is lower in boys with autism spectrum disorders (ASD) than controls, and also assessed variables that may affect BMD in ASD. BMD was measured using dual energy X-ray absorptiometry (DXA) in 18 boys with ASD and 19 controls 8–14 years old. Boys with ASD had lower BMD Z-scores at the spine, hip and femoral neck, and differences at the hip and femoral neck persisted after controlling for maturity and BMI. Vitamin D intake from food and in serum were lower in ASD subjects, as was exercise activity. We conclude that BMD is lower in peripubertal boys with ASD and may be associated with impaired vitamin D status and lower exercise activity.

Keywords

Autism Autism spectrum disorder Bone density Puberty Bone turnover Bone metabolism 

Abbreviations

BMD

Bone mineral density

BMAD

Bone mineral apparent density

DXA

Dual energy X-ray absorptiometry

ASD

Autism spectrum disorder

IGF-1

Insulin-like growth factor-1

TSH

Thyroid stimulating hormone

T4

Thyroxine

P1NP

N-terminal propeptide of Type 1 procollagen

NTX

N-telopeptide

SGBG

Sex hormone binding globulin

SD

Standard deviation

SE

Standard error

CV

Coefficient of variation

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Copyright information

© Springer Science+Business Media New York 2012

Authors and Affiliations

  • Ann M. Neumeyer
    • 1
  • Amy Gates
    • 4
  • Christine Ferrone
    • 4
  • Hang Lee
    • 2
  • Madhusmita Misra
    • 3
  1. 1.Lurie Center for AutismMassachusetts General Hospital and Harvard Medical SchoolLexingtonUSA
  2. 2.Biostatistics CenterMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  3. 3.Pediatric Endocrine and Neuroendocrine UnitsMassachusetts General Hospital and Harvard Medical SchoolBostonUSA
  4. 4.Lurie Center for AutismMassachusetts General HospitalLexingtonUSA

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