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Journal of Autism and Developmental Disorders

, Volume 43, Issue 4, pp 973–977 | Cite as

Brief Report: Asperger’s Syndrome and Sibling Birth Order

  • Karmen Schmidt
  • Andrew Zimmerman
  • Margaret Bauman
  • Christine Ferrone
  • Jacob Venter
  • Jessaca Spybrook
  • Charles HenryEmail author
Brief Report

Abstract

Prior investigations suggest that birth order position may be associated with the risk for developing a pervasive developmental disorder. This retrospective chart review examined the birth order status of 29 psychiatrically-referred patients with Asperger’s Syndrome (AS). Eighty-six percent of the subjects were first born. The finding was statistically significant when compared to an expected random distribution of AS subjects χ2 (1, N = 29) = 9.18, p < 0.01. The reasons for such an association are unclear though birth stoppage, obstetric complications, and immunological mechanisms may play a role.

Keywords

Asperger’s syndrome Pervasive developmental disorders Birth order Epidemiology 

Notes

Conflict of interest

This project was funded under partial support from the Casa Colina Foundation.

References

  1. American Psychiatric Association. (2000). Diagnostic and statistical manual for mental disorder, fourth edition, text revision. Washington, DC: American Psychiatric Association.Google Scholar
  2. Atladóttir, H. O., Pedersen, M. G., Thorsen, P., Mortensen, P. B., Deleuran, B., Eaton, W. W., et al. (2009). Association of family history of autoimmune diseases and autism spectrum disorders. Pediatrics, 124, 687–694.PubMedCrossRefGoogle Scholar
  3. Bhatia, M. S., Nigam, V. R., Bohra, N., & Malik, S. C. (1991). Attention deficit disorder with hyperactivity among pediatric outpatients. Journal of Child Psychology and Psychiatry, 32(2), 297–306.PubMedCrossRefGoogle Scholar
  4. Bloemen, O. J. N., Deeley, Q., Sundram, F., Daly, E. M., Barker, G. J., Jones, D. K., et al. (2010). White matter integrity in Asperger syndrome: A preliminary diffusion tensor magnetic resonance imaging study in adults. Autism Research, 3, 203–213.PubMedCrossRefGoogle Scholar
  5. Bolton, P. F., Murphy, M., MacDonald, H., Whitlock, B., Pickles, A., & Rutter, M. (1997). Obstetric complications in autism: Consequences or causes of the condition. Journal of the American Academy of Child and Adolescent Psychiatry, 36(2), 272–281.PubMedCrossRefGoogle Scholar
  6. Braunschweig, D., Ashwood, P., Krakowiak, P., Hertz-Picciotto, I., Hansen, R., Croen, L. A., et al. (2008). Autism: Maternally derived antibodies specific for fetal brain proteins. NeuroToxicology, 29(2), 226–231.PubMedGoogle Scholar
  7. Braunschweig, D., Duncanson, P., Boyce, R., Hansen, R., Ashwood, P., Pessah, I. N., et al. (2011). Behavioral correlates of maternal antibody status among children with autism. Journal of Autism and Developmental Disorders,. doi: 10.1007/s10803-011-1378-7.Google Scholar
  8. Cederlund, M., & Gillberg, C. (2004). One hundred males with Asperger syndrome: A clinical study of background and associated factors. Developmental Medicine and Child Neurology, 46, 652–660.PubMedCrossRefGoogle Scholar
  9. Comi, A. M., Zimmerman, A. W., Frye, V. H., Law, P. A., & Peeden, J. N. (1999). Familial clustering of autoimmune disorders and evaluation of medical risk factors in autism. Journal of Child Neurology, 14(6), 388–394.PubMedCrossRefGoogle Scholar
  10. Croen, L. A., Braunschweig, D., Haapanen, L., Yoshida, C. K., Fireman, B., Grether, J. K., et al. (2008). Maternal mid-pregnancy autoantibodies to fetal brain protein: The early markers for autism study. Biological Psychiatry, 64, 583–588.PubMedCrossRefGoogle Scholar
  11. Croen, L. A., Grether, J. K., Yoshida, C. K., Odouli, R., & Van de Water, J. (2005). Maternal autoimmune diseases, asthma and allergies, and childhood autism spectrum disorders. Archives of Pediatrics and Adolescent Medicine, 159, 151–157.PubMedCrossRefGoogle Scholar
  12. Croen, L. A., Najjar, D. V., Fireman, B., & Grether, J. K. (2007). Maternal and paternal age and risk of autism spectrum disorders. Archives of Pediatric and Adolescent Medicine, 161, 334–340.CrossRefGoogle Scholar
  13. Deykin, E. Y., & MacMahon, B. (1980). Pregnancy, delivery and neonatal complications among autistic children. Archives of Pediatrics and Adolescent Medicine, 134(9), 860–864.CrossRefGoogle Scholar
  14. Durkin, M. S., Maenner, M. J., Newshaffer, C. J., Lee, L., Cunniff, C. M., Daniels, J. L., et al. (2008). Advanced parental age and the risk of autism spectrum disorder. American Journal of Epidemiology, 168(11), 1268–1276.PubMedCrossRefGoogle Scholar
  15. Eaton, W. W., Mortensen, P. B., Thomsen, P. H., & Frydenberg, M. (2001). Obstetric complications and risk for severe psychopathology in childhood. Journal of Autism and Developmental Disorders, 31(3), 279–285.PubMedCrossRefGoogle Scholar
  16. Eskenazi, B., Fenster, L., & Sidney, S. (1991). A multivariate analysis of risk factors for preeclampsia. Journal of the American Medical Association, 266(2), 237–241.PubMedCrossRefGoogle Scholar
  17. Gardener, H., Spiegelman, D., & Buka, S. L. (2009). Prenatal risk factors for autism: Comprehensive meta-analysis. The British Journal of Psychiatry, 195, 7–14.PubMedCrossRefGoogle Scholar
  18. Gaughran, F., Blizard, R., Mohan, R., Zammit, S., & Owen, M. (2007). Birth order and the severity of illness in schizophrenia. Psychiatry Research, 150, 205–210.PubMedCrossRefGoogle Scholar
  19. Ghaziuddin, M. (2010). Brief report: Should the DSM V drop Asperger syndrome. Journal of Autism and Developmental Disorders, 40, 1146–1148.PubMedCrossRefGoogle Scholar
  20. Gillberg, C. (1989). Asperger syndrome in 23 Swedish children. Developmental Medicine and Child Neurology, 31(4), 520–531.PubMedCrossRefGoogle Scholar
  21. Glasson, E. J., Bower, C., Petterson, B., de Klerk, N., Chaney, G., & Hallmayer, J. F. (2004). Perinatal factors and the development of autism: A population study. Archives of General Psychiatry, 61, 618–627.PubMedCrossRefGoogle Scholar
  22. Greenwood, M., & Yule, U. G. (1914). On the determination of size of family and of the distribution of characters in order of birth from samples taken through members of the sibships. Journal of the Royal Statistical Society, 77(2), 179–199.CrossRefGoogle Scholar
  23. Happé, F. (2011). Criteria, categories, and continua: Autism and related disorders in DSM-5. Journal of the American Academy of Child and Adolescent Psychiatry, 50(6), 540–542.PubMedCrossRefGoogle Scholar
  24. Howlin, P., & Asgharian, A. (1999). The diagnosis of autism and Asperger syndrome: Findings from a survey of 770 families. Developmental Medicine and Child Neurology, 41, 834–839.PubMedCrossRefGoogle Scholar
  25. Johnson, W. G., Buyske, S., Mars, A. E., Sreenath, M., Stenroos, E. S., Williams, T. A., et al. (2009). HLA-DR4 as a risk allele for autism acting in mothers of probands possibly during pregnancy. Archives of Pediatricts and Adolescent Medicine, 163(6), 542–546.CrossRefGoogle Scholar
  26. Jones, M. B., & Szatmari, P. (1988). Stoppage rules and genetic studies of autism. Journal of Autism and Developmental Disorders, 18(1), 31–40.PubMedCrossRefGoogle Scholar
  27. Karmaus, W., Arshad, H., & Mattes, J. (2001). Does the sibling effect have its origin in utero? Investigating birth order, cord blood immunoglobulin E concentration, and allergic sensitization at age 4 years. American Journal of Epidemiology, 154(10), 909–915.PubMedCrossRefGoogle Scholar
  28. Karmaus, W., Arshad, S. H., Sadeghnejad, A., & Twiselton, R. (2004). Does maternal immunoglobulin E decrease with increasing order of live offspring? Investigation into maternal immune tolerance. Clinical and Experimental Allergy, 34, 853–859.PubMedCrossRefGoogle Scholar
  29. Karmaus, W., & Botezan, C. (2002). Does a higher number of siblings protect against the development of allergy and asthma? A review. Journal of Epidemiology and Community Health, 56, 209–217.PubMedCrossRefGoogle Scholar
  30. Lee, A. C. C., Mullany, L. C., Tielsch, J. M., Katz, J., Khatry, S. K., LeClerq, S. C., et al. (2011). Incidence of and risk factors for neonatal respiratory depression and encephalopathy in rural Sarlahi. Nepal Pediatrics, 128(4), 915–924.CrossRefGoogle Scholar
  31. Lee, L., Zachary, A. A., Leffell, M. S., Newschaffer, C. J., Matteson, K. J., Tyler, J. D., et al. (2006). HLA-DR4 in families with autism. Pediatric Neurology, 35(5), 303–307.PubMedCrossRefGoogle Scholar
  32. Lord, C., Mulloy, C., Wendelboe, M., & Schopler, E. (1991). Pre- and perinatal factors in high-functioning females and males with autism. Journal of Autism and Developmental Disorders, 21(2), 197–209.PubMedCrossRefGoogle Scholar
  33. Magalhães, E. S., Pinto-Mariz, F., Bastos-Pinto, S., Pontes, A. T., Prado, E. A., & deAzevedo, L. C. (2009). Immune allergic response in Asperger syndrome. Journal of Neuroimmunology, 216, 108–112.PubMedCrossRefGoogle Scholar
  34. Martin, L. A., Ashwood, P., Braunschweig, D., Cabanlit, M., Van de Water, J., & Amaral, D. G. (2008). Stereotypies and hyperactivity in rhesus monkeys exposed to IgG from mothers of children with autism. Brain, Behavior, and Immunity, 22, 806–816.PubMedCrossRefGoogle Scholar
  35. Mattila, M.-L., Hurtic, T., Haapsamo, H., Jussila, K., Kuusikko-Gauffin, S., Kielinen, M., et al. (2010). Comorbid psychiatric disorders associated with Asperger syndrome/high functioning autism: A community- and clinic-based study. Journal of Autism and Developmental Disorders, 40, 1080–1093.PubMedCrossRefGoogle Scholar
  36. O’Leary, C., de Klerk, N., Keogh, J., Pennell, C., de Groot, J., York, L., et al. (2007). Trends in mode of delivery during 1984–2003: Can they be explained by pregnancy and delivery complications. BJOG: An international Journal of Obstetrics and Gynaecology, 114(7), 855–864.CrossRefGoogle Scholar
  37. Ogbuanu, I. U., Karmaus, W. J., Zhang, H., Sabo-Attwood, T., Ewart, S., Roberts, G., Arshad, S. H. (2010). Birth order modifies the effect of IL13 gene polymorphisms on serum IgE at age 10 and skin prick test at ages 4, 10 and 18: A prospective birth cohort study. Allergy, Asthma & Clinical Immunology, 6(6). doi:10.1186/1710-1492-6-6.
  38. Piven, J., Simon, J., Chase, G. A., & Wzorek, M. (1993). The etiology of autism: Pre-, peri- and neonatal factors. Journal of the American Academy of Child and Adolescent Psychiatry, 32(6), 1256–1263.PubMedCrossRefGoogle Scholar
  39. Rehnström, K., Ylisaukko-oja, T., Nieminen-von Wendt, T., Sarenius, S., Källman, T., Kempas, E., Wendt, L. von, Peltonen, L., & Järvelä, I. (2006). Independent replication and initial fine mapping of 3p21–24 in Asperger syndrome. Journal of Medical Genetics, 43(2), pp. 6. doi: 10.1136/jmg.2005.033621.
  40. Reichenberg, A., Smith, C., Schmeidler, J., & Silverman, J. M. (2007). Birth order effects on autism symptom domains. Psychiatry Research, 150, 199–204.PubMedCrossRefGoogle Scholar
  41. Rosenberg, R. E., Kaufmann, W. E., Law, J. K., & Law, P. A. (2011). Parent Report of Community Psychiatric Comorbid Diagnoses in Autism Spectrum Disorders. Autism Research and Treatment, 2011, pp. 10. doi: 10.1155/2011/405849.Google Scholar
  42. Salyakina, D., Ma, D. Q., Jaworski, J. M., Konidari, I., Whitehead, P. L., Henson, R., et al. (2010). Variants in several genomic regions associated with Asperger disorder. Autism Research, 3(6), 303–310.PubMedCrossRefGoogle Scholar
  43. Singer, H. S., Morris, C. M., Gause, C. D., Gillin, P. K., Crawford, S., & Zimmerman, A. W. (2008). Antibodies against fetal brain in sera of mothers with autistic children. Journal of Neuroimmunology, 194, 165–172.PubMedCrossRefGoogle Scholar
  44. Singer, H. S., Morris, C., Gause, C., Pollard, M., Zimmerman, A. W., & Pletnikov, M. (2009). Prenatal exposure to antibodies from mothers of children with autism produces neurobehavioral alterations: A pregnant dam mouse model. Journal of Neuroimmunology, 211, 39–48.PubMedCrossRefGoogle Scholar
  45. Slager, S. L., Foroud, T., Haghighi, F., Spence, M. A., & Hodge, S. E. (2001). Stoppage: An issue for segregation analysis. Genetic Epidemiology, 20, 328–339.PubMedCrossRefGoogle Scholar
  46. Spiker, D., Lotspeich, L. J., Dimiceli, S., Szatmari, P., Myers, R. M., & Risch, N. (2001). Birth order effects on nonverbal IQ scores in autism multiplex families. Journal of Autism and Developmental Disorders, 31(5), 449–460.PubMedCrossRefGoogle Scholar
  47. Stanton-Chapman, T. L., Chapman, D. A., Bainbridge, N. L., & Scott, K. G. (2002). Identification of early risk factors for language impairment. Research in Developmental Disabilities, 23(6), 390–405.PubMedCrossRefGoogle Scholar
  48. Sunyer, J., Anto, J. M., Harris, J., Torrent, M., Vall, O., Cullinan, P., et al. (2001). Maternal atopy and parity. Clinical and Experimental Allergy, 31, 1352–1355.PubMedCrossRefGoogle Scholar
  49. Sweeten, T. L., Bowyer, S. L., Posey, D. J., Halberstadt, G. M., & McDougal, C. J. (2003). Increased prevalence of familial autoimmunity in probands wit pervasive developmental disorders. Pediatrics, 112(5), e420–e424. doi: 10.1542/peds.112.5.e420.PubMedCrossRefGoogle Scholar
  50. Tsai, L. Y., & Stewart, M. A. (1983). Etiological implications of maternal age and birth order in infantile autism. Journal of Autism and Developmental Disorders, 133(1), 57–65.CrossRefGoogle Scholar
  51. Via, E., Radua, J., Cardoner, N., Happé, F., & Mataix-Cols, D. (2011). Meta-analysis of gray matter abnormalities in autism spectrum disorder: Should Asperger disorder be subsumed under a broader umbrella of autistic spectrum disorder. Archives of General Psychiatry, 68(4), 409–418.PubMedCrossRefGoogle Scholar
  52. Wills, S., Cabanlit, M., Bennett, J., Ashwood, P., Amaral, D. G., & Van de Water, J. (2009). Detection of autoantibodies to neural cells of the cerebellum in the plasma of subjects with autism spectrum disorders. Brain, Behavior, and Immunity, 23(1), 64–74.PubMedCrossRefGoogle Scholar
  53. Zimmerman, A. W., Connors, S. L., Matteson, K. J., Lee, L., Singer, H. S., Castaneda, J. A., et al. (2007). Maternal antibrain antibodies in autism. Brain, Behavior, and Immunity, 21(3), 351–357.PubMedCrossRefGoogle Scholar
  54. Zimmerman, A. W., Jyonouchi, H., Comi, A. M., Connors, S. L., Milstien, S., Varsou, A., et al. (2005). Cerebrospinal fluid and serum markers of inflammation in autism. Pediatric Neurology, 33(3), 195–201.PubMedCrossRefGoogle Scholar
  55. Zwaigenbaum, L., Szatmari, P., Jones, M. B., Bryson, S. E., Maclean, J. E., Mahoney, W. J., et al. (2002). Pregnancy and birth complications in autism and liability to the broader autism phenotype. Journal of the American Academy of Child and Adolescent Psychiatry, 41(5), 572–579.PubMedCrossRefGoogle Scholar

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Karmen Schmidt
    • 1
  • Andrew Zimmerman
    • 1
  • Margaret Bauman
    • 1
  • Christine Ferrone
    • 1
  • Jacob Venter
    • 2
    • 4
  • Jessaca Spybrook
    • 3
  • Charles Henry
    • 4
    • 5
    Email author
  1. 1.Department of PediatricsMassachusetts General HospitalBostonUSA
  2. 2.Department of PsychiatryCambridge Health AllianceCambridgeUSA
  3. 3.Evaluation, Measurement, and Research DepartmentWestern Michigan UniversityKalamazooUSA
  4. 4.Department of PsychiatryMassachusetts General HospitalBostonUSA
  5. 5.LexingtonUSA

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