Journal of Autism and Developmental Disorders

, Volume 42, Issue 11, pp 2312–2322

A Two-Year Longitudinal MRI Study of the Corpus Callosum in Autism

  • Thomas W. Frazier
  • Matcheri S. Keshavan
  • Nancy J. Minshew
  • Antonio Y. Hardan
Original Paper

DOI: 10.1007/s10803-012-1478-z

Cite this article as:
Frazier, T.W., Keshavan, M.S., Minshew, N.J. et al. J Autism Dev Disord (2012) 42: 2312. doi:10.1007/s10803-012-1478-z


A growing body of literature has identified size reductions of the corpus callosum (CC) in autism. However, to our knowledge, no published studies have reported on the growth of CC volumes in youth with autism. Volumes of the total CC and its sub-divisions were obtained from 23 male children with autism and 23 age- and gender-matched controls at baseline and 2-year follow-up. Persistent reductions in total CC volume were observed in participants with autism relative to controls. Only the rostral body subdivision showed a normalization of size over time. Persistent reductions are consistent with the diagnostic stability and life-long impairment observed in many individuals with autism. Multi-modal imaging studies are needed to identify specific fiber tracks contributing to CC reductions.


Magnetic resonance imaging Autism Corpus callosum Rostral body 

Copyright information

© Springer Science+Business Media, LLC 2012

Authors and Affiliations

  • Thomas W. Frazier
    • 1
  • Matcheri S. Keshavan
    • 2
  • Nancy J. Minshew
    • 3
  • Antonio Y. Hardan
    • 4
  1. 1.Center for Autism (CRS10) and Pediatric Behavioral HealthCleveland ClinicClevelandUSA
  2. 2.Department of Psychiatry, Beth Israel and Deaconess Medical CenterHarvard Medical SchoolBostonUSA
  3. 3.Western Psychiatric Institute and ClinicUniversity of Pittsburgh School of MedicinePittsburghUSA
  4. 4.Department of Psychiatry and Behavioral SciencesStanford UniversityStanfordUSA

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