Substantial Problems with Measuring Brain Mitochondrial Dysfunction in Autism Spectrum Disorder Using Magnetic Resonance Spectroscopy

This is a preview of subscription content, log in to check access.


  1. Bates, T. E., Strangward, M., Keelan, J., Davey, G. P., Munro, P. M., & Clark, J. B. (1996). Inhibition of N-acetylaspartate production: Implications for 1H MRS studies in vivo. Neuroreport, 7, 1397–1400.

    PubMed  Article  Google Scholar 

  2. Boumezbeur, F., Mason, G. F., de Graaf, R. A., Behar, K. L., Cline, G. W., Shulman, G. I., et al. (2010). Altered brain mitochondrial metabolism in healthy aging as assessed by in vivo magnetic resonance spectroscopy. Journal of Cerebral Blood Flow and Metabolism, 30, 211–221.

    PubMed  Article  Google Scholar 

  3. Chauhan, A., F. Gu, M.M. Essa, J. Wegiel, K. Kaur.,& W. Ted Brown, et al. (2011). Brain region-specific deficit in mitochondrial electron transport chain complexes in children with autism. Journal of neurochemistry.

  4. Clark, J. B. (1998). N-acetyl aspartate: A marker for neuronal loss or mitochondrial dysfunction. Developmental Neuroscience, 20, 271–276.

    PubMed  Article  Google Scholar 

  5. Corrigan, N.M., D.W. Shaw, T.L. Richards, A.M. Estes, S.D. Friedman., & H. Petropoulos, et al. (2011). Proton magnetic resonance spectroscopy and MRI reveal no evidence for brain mitochondrial dysfunction in children with autism spectrum disorder. Journal of autism and developmental disorders.

  6. Ezugha, H., M. Goldenthal, I. Valencia, C.E. Anderson, A. Legido., & H. Marks. (2010). 5q14.3 Deletion manifesting as mitochondrial disease and autism: Case report. Journal of child neurology.

  7. Friedman, S. D., Shaw, D. W., Artru, A. A., Richards, T. L., Gardner, J., Dawson, G., et al. (2003). Regional brain chemical alterations in young children with autism spectrum disorder. Neurology, 60, 100–107.

    PubMed  Google Scholar 

  8. Friedman, S. D., Shaw, D. W., Artru, A. A., Dawson, G., Petropoulos, H., & Dager, S. R. (2006). Gray and white matter brain chemistry in young children with autism. Archives of General Psychiatry, 63, 786–794.

    PubMed  Article  Google Scholar 

  9. Giulivi, C., Zhang, Y. F., Omanska-Klusek, A., Ross-Inta, C., Wong, S., Hertz-Picciotto, I., et al. (2010). Mitochondrial dysfunction in autism. JAMA, 304, 2389–2396.

    PubMed  Article  Google Scholar 

  10. Graf, W. D., Marin-Garcia, J., Gao, H. G., Pizzo, S., Naviaux, R. K., Markusic, D., et al. (2000). Autism associated with the mitochondrial DNA G8363A transfer RNA(Lys) mutation. Journal of Child Neurology, 15, 357–361.

    PubMed  Article  Google Scholar 

  11. Pons, R., Andreu, A. L., Checcarelli, N., Vila, M. R., Engelstad, K., Sue, C. M., et al. (2004). Mitochondrial DNA abnormalities and autistic spectrum disorders. Journal of Pediatrics, 144, 81–85.

    PubMed  Article  Google Scholar 

  12. Rossignol, D.A., & R. E. Frye. (2011). Mitochondrial dysfunction in autism spectrum disorders: A systematic review and meta-analysis. Molecular psychiatry.

  13. Weissman, J. R., Kelley, R. I., Bauman, M. L., Cohen, B. H., Murray, K. F., Mitchell, R. L., et al. (2008). Mitochondrial disease in autism spectrum disorder patients: A cohort analysis. PLoS ONE, 3, e3815.

    PubMed  Article  Google Scholar 

Download references

Author information



Corresponding author

Correspondence to Daniel A. Rossignol.

Rights and permissions

Reprints and Permissions

About this article

Cite this article

Rossignol, D.A., Frye, R.E. Substantial Problems with Measuring Brain Mitochondrial Dysfunction in Autism Spectrum Disorder Using Magnetic Resonance Spectroscopy. J Autism Dev Disord 42, 640–642 (2012).

Download citation


  • Autism Spectrum Disorder
  • Autism Spectrum Disorder
  • Mitochondrial Dysfunction
  • Magnetic Resonance Spectroscopy
  • Mitochondrial Disease