Journal of Autism and Developmental Disorders

, Volume 41, Issue 4, pp 395–404 | Cite as

Progress in Understanding Autism: 2007–2010

Original Paper

Abstract

Scientific progress is discussed in relation to clinical issues; genetic issues; environmental issues; and the state of play on psychological treatments. It is concluded that substantial gains in knowledge have been achieved during the last 3 years, and there have been some unexpected findings, but major puzzles remain. We should be hopeful of ever greater gains in the years ahead, but both prevention and cure remain elusive.

Keywords

Scientific advances Research challenges 

References

  1. Abrahams, B. S., & Geschwind, D. H. (2008). Advances in autism genetics: On the threshold of a new neurobiology. Nature Review: Genetics, 9, 341–355.CrossRefGoogle Scholar
  2. Afzal, M. A., Ozoemena, L. C., O’Hare, A., Kidger, K. A., Bentley, M. L., & Minor, P. D. (2006). Absence of detectable measles virus genome sequence in blood of autistic children who have had their MMR vaccination during the routine childhood immunization schedule of UK. Journal of Medical Virology, 78, 623–630.PubMedCrossRefGoogle Scholar
  3. Asperger, H. (1944). Die ‘Autistischen Psychopathen’ im Kindesalter [Trans. ‘Autistic psychopathy’ in childhood]. Archiv fur Psychiatrie und Nervenkrankheiten, 117, 76–136.CrossRefGoogle Scholar
  4. Atladóttir, H. O., Parner, E. T., Schendel, D., Dalsgaard, S., Thomsen, P. H., & Thorsen, P. (2007). Time trends in reported diagnoses of childhood neuropsychiatric disorders: A Danish cohort study. Archives of Pediatric and Adolescent Medicine, 161, 193–198.CrossRefGoogle Scholar
  5. Bacchelli, A., & Maestrini, E. (2006). Autism spectrum disorders: Molecular genetic advances. American Journal of Medical Genetics C. Seminars in Medical Genetics, 142, 13–23.CrossRefGoogle Scholar
  6. Bailey, A., Le Couteur, A., Gottesman, I., Bolton, P., Simonoff, E., Yuzda, F. Y., et al. (1995). Autism as a strongly genetic disorder: Evidence from a British twin study. Psychological Medicine, 25, 63–77.PubMedCrossRefGoogle Scholar
  7. Bailey, A., Palferman, S., Heavey, L., & Le Couteur, A. (1998). Autism: The phenotype in relatives. Journal of Autism and Developmental Disorders, 28, 369–392.PubMedCrossRefGoogle Scholar
  8. Bailey, A., & Parr, J. (2003). Implications of the broader phenotype for concepts of autism. In G. Bock & J. Goode (Eds.), Autism: Neural basis and treatment possibilities (pp 26–36). Chichester, UK: Wiley.Google Scholar
  9. Baird, G., Charman, T., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., et al. (2008a). Regression, developmental trajectory and associated problems in disorders in the autism spectrum. The SNAP Study, Journal of Autism& Developmental Disorders, 38, 1827–1836.CrossRefGoogle Scholar
  10. Baird, G., Pickles, A., Simonoff, E., Charman, T., Sullivan, P., Chandler, S., et al. (2008b). Measles vaccination and antibody response in autism spectrum disorders. Archives of Disease in Childhood, 93, 832–837.PubMedCrossRefGoogle Scholar
  11. Berument, S. K., Rutter, M., Lord, C., Pickles, A., & Bailey, A. (1999). Autism screening questionnaire: Diagnostic validity. British Journal of Psychiatry, 175, 444–445.PubMedCrossRefGoogle Scholar
  12. Bolton, P. F., Carcani-Rathwell, I., Hutton, J., Goode, S., Howlin, P., & Rutter, M. L. (in press). Features and correlates of epilepsy in autism. British Journal of Psychiatry.Google Scholar
  13. Bourgeron, T. (2007). The possible interplay of synaptic and clock genes in autism spectrum disorders. Cold Spring Harbor Symposia on Quantitative Biology, 72, 645–654.PubMedCrossRefGoogle Scholar
  14. Bryson, S. E., Zwaigenbaum, L., Brian, J., Roberts, W., Szatmari, P., Rombough, V., et al. (2007). A prospective cases series of high-risk infants who developed autism. Journal of Autism and Developmental Disorders, 37, 12–24.PubMedCrossRefGoogle Scholar
  15. Buitelaar, J. K. (2003). Why have drug treatments been so disappointing? In G. Bock & J. Goode (Eds.), Autism: Neural basis and treatment possibilities (pp. 235–249). Chichester, UK: Wiley.CrossRefGoogle Scholar
  16. Cantor, R. M., Yoon, J. L., Fuur, J., & Lajonchere, C. M. (2007). Paternal age and autism are associated in a family-based sample. Molecular Psychiatry, 12, 419–423.PubMedCrossRefGoogle Scholar
  17. Cook, E. H., & Scherer, S. W. (2008). Copy-number variations associated with neuropsychiatric conditions. Nature, 455(7215), 919–923.PubMedCrossRefGoogle Scholar
  18. Courchesne, E., Carper, R., & Akshoomoff, N. (2003). Evidence of brain overgrowth in the first year of life in autism. Journal of the American Medical Association, 290, 337–344.PubMedCrossRefGoogle Scholar
  19. Courchesne, E., Pierce, K., Schumann, C., Redcay, E., Buckwalter, J., Kennedy, D., et al. (2007). Mapping early brain development in autism. Neuron, 56, 399–413.PubMedCrossRefGoogle Scholar
  20. Croen, L. A., Najjar, D. V., Fireman, B., & Grether, J. K. (2007). Maternal and paternal age and risk of autism spectrum disorders. Archives of Pediatric and Adolescent Medicine, 161, 334–340.CrossRefGoogle Scholar
  21. D’Souza, Y., Fombonne, E., & Ward, B. J. (2006). No evidence of persisting measles virus in peripheral blood mononuclear cells from children with autism spectrum disorder. Pediatrics, 118, 1664–2608.PubMedCrossRefGoogle Scholar
  22. Dawson, G., Estes, A., Munson, J., Schellenberg, G., Bernier, R., Abott, R., et al. (2007). Quantitative assessment of autism symptom-related traits in probands and parents: Broader phenotype autism symptom scale. Journal of Autism and Developmental Disorders, 37, 523–536.PubMedCrossRefGoogle Scholar
  23. Dawson, G., Rogers, S., Munson, J., Smith, M., Winter, J., Greenson, J., et al. (2009). Randomized, controlled trial of an intervention for toddlers with autism: The early start Denver model. Pediatrics, 125, 17–23.CrossRefGoogle Scholar
  24. Dietz, C., Swinkels, S., van Daalen, E., van Engeland, H., & Buitelaar, J. K. (2006). Screening for autistic spectrum disorder in children aged 14–15 months. II. Population screening with the early screening of autistic traits questionnaire (ESAT): Design and general findings. Journal of Autism and Developmental Disorders, 36, 713–722.PubMedCrossRefGoogle Scholar
  25. Dodge, K. A., & Rutter, M. (Eds.). (in press). Geneenvironment interactions in developmental psychopathology: So what? New York: Guilford Press.Google Scholar
  26. Durand, C. M., Betancur, C., Boeckers, T. M., Bockman, J., Chaste, P., Faucherau, F., et al. (2007). Mutations in the gene encoding the synaptic scaffolding protein SHANK3 are associated with autism spectrum disorders. Nature Genetics, 39, 25–27.PubMedCrossRefGoogle Scholar
  27. Elsabbagh, M., & Johnson, M. H. (2010). Getting answers from babies about autism. Trends Cognitive Science, 4, 81–87.CrossRefGoogle Scholar
  28. Feinstein, A. (2010). A history of autism: Conversations with the pioneers. Chichester, UK: Wiley Blackwell.CrossRefGoogle Scholar
  29. Folstein, S. E., & Rosen-Sheidley, B. (2001). Genetics of autism: Complex aetiology for a heterogeneous disorder. Nature Reviews: Genetics, 2, 943–955.PubMedCrossRefGoogle Scholar
  30. Folstein, S., & Rutter, M. (1977). Infantile autism: A genetic study of 21 twin pairs. Journal of Child Psychology and Psychiatry, 18, 297–321.PubMedCrossRefGoogle Scholar
  31. Fombonne, E. (2005). Epidemiological studies of pervasive developmental disorders. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp 62–63). Hoboken, NJ: Wiley.Google Scholar
  32. Frith, U. (1989). Autism: Explaining the enigma. Oxford, UK: Blackwell Publishing.Google Scholar
  33. Frith, U. (2003). Autism: Explaining the enigma (2nd ed.). Oxford: Blackwell.Google Scholar
  34. Frith, C., & Frith, U. (2008). What can we learn from structural and functional brain imaging? In M. Rutter, D. Bishop, D. Pine, S. Scott, J. Stevenson, E. Taylor, & A. Thapar (Eds.), Rutter’s child and adolescent psychiatry (5th ed., pp. 134–144). Massachusetts, USA: Blackwell Publishing.CrossRefGoogle Scholar
  35. Geschwind, D. H., & Levitt, P. (2007). Autism spectrum disorders: Developmental disconnection syndromes. Current Opinion in Neurobiology, 17, 103–111.PubMedCrossRefGoogle Scholar
  36. Gotham, K., Risi, S., Pickles, A., & Lord, C. (2007). The autism diagnostic observation schedule: Revised algorithms for improved diagnostic validity. Journal of Autism and Developmental Disorders, 37, 613–627.PubMedCrossRefGoogle Scholar
  37. Goulden, K. J., Shinnar, S., Koller, H., Katz, M., & Richardson, S. A. (1991). Epilepsy in children with mental retardation: A cohort study. Epilepsia, 32, 690–697.PubMedCrossRefGoogle Scholar
  38. Green, J., Charman, T., McConachie, H., Aldred, C., Slonims, V., Howlin, P., et al. (2010). Parent-mediated communication-focused treatment in children with autism (PACT): A randomized controlled trial. The Lancet, 375, 2152–2160.CrossRefGoogle Scholar
  39. Gregory, S. G., Connelly, J. J., Towers, A. J., Johnson, J., Bisocho, D., Markunas, C. A., et al. (2009). Genomic and epigenetic evidence for oxytocin receptor deficiency in autism. BMC Medicine, 7, 62. doi:10.1186/1741-7015-7-62.PubMedCrossRefGoogle Scholar
  40. Happé, F. (2003). Cognition in autism: One deficit or many? Autism: Neural basis and treatment possibilities. Novartis Foundation Symposium, 251, 198–212.PubMedCrossRefGoogle Scholar
  41. Happé, F. (2005). The weak central coherence account of autism. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp. 640–649). Hoboken, NJ: Wiley.Google Scholar
  42. Happé, F., & Ronald, A. (2008). The ‘fractionable autism triad’: A review of evidence from behavioural, genetic, cognitive and neural research. Neuropsychological Review, 18(4), 287–304.CrossRefGoogle Scholar
  43. Helt, M., Kelley, E., Kinsbourne, M., Pandey, J., Boorstein, H., Herbert, M., et al. (2008). Can children with autism recover? If so, how? Neuropsychology Review, 18, 339–366.PubMedCrossRefGoogle Scholar
  44. Hermelin, B. (2001). Bright splinters of the mind. London, UK: Jessica Kingsley Publishers.Google Scholar
  45. Honda, H., Shimizu, Y., & Rutter, M. (2005). No effect of MMR withdrawal on the incidence of autism: A total population study. Journal of Child Psychology and Psychiatry, 46, 572–579.PubMedCrossRefGoogle Scholar
  46. Hornig, M., Brieses, T., Buie, T., Mauman, M. L., Lauwers, G., Siemetzki, U., et al. (2008). Lack of association between measles virus vaccine and autism with enteropathy: A case-control study. PLoS One, 3, e3140.PubMedCrossRefGoogle Scholar
  47. Howlin, P. (2003). Can early interventions alter the course of autism? In G. Bock & J. Goode (Eds.), Autism: Neural basis and treatment possibilities (pp. 250–265). Chichester, UK: Wiley.CrossRefGoogle Scholar
  48. Howlin, P. (2005). The effectiveness of interventions for children with autism. Journal of Neural Transmission (Suppementum), 69, 101–119.Google Scholar
  49. Howlin, P., Goode, S., Hutton, J., & Rutter, M. (2004). Adult outcomes for children with autism. Journal of Child Psychology and Psychiatry, 45, 212–229.PubMedCrossRefGoogle Scholar
  50. Howlin, P., Goode, S., Hutton, J., & Rutter, M. (2010). Savant skills in autism: Psychometric approaches and parental reports. In F. Happé & U. Frith (Eds.), Autism and talent (pp. 13–24). Oxford: University Press.Google Scholar
  51. Hutton, J., Goode, S., Murphy, M., Le Couteur, A., & Rutter, M. (2008). New-onset psychiatric disorders in individuals with autism. Autism, 12(4), 373–390.PubMedCrossRefGoogle Scholar
  52. International Schizophrenia Consortium. (2008). Rare chromosomal deletions and duplications increase risk of schizophrenia. Nature, 455, 237–241.CrossRefGoogle Scholar
  53. Jamain, S., Radyushkin, K., Hammerschmidt, K., Granon, S., Boretius, S., Varoqueaux, F., et al. (2008). Reduced social interaction and ultrasonic communication in a mouse model of monogenic heritable autism. Proceedings of the National Academy of Sciences of the USA, 5, 1710–1715.CrossRefGoogle Scholar
  54. Kanner, L. (1971). Follow-up study of eleven autistic children originally reported in 1943. Journal of Autism and Childhood Schizophenia, 1, 119–145.CrossRefGoogle Scholar
  55. Keen, D. V., Reid, F. D., & Arnone, D. (2010). Autism, ethnicity and maternal immigration. British Journal of Psychiatry, 196, 274–281.PubMedCrossRefGoogle Scholar
  56. Keller, F., & Persico, A. M. (2003). The neurobiological context of autism. Molecular Neurobiology, 28, 1–22.PubMedCrossRefGoogle Scholar
  57. Klin, A., Jones, W., Schultz, R. T., & Volkmar, F. (2005). The enactive mind—from actions to cognition: Lessons from autism. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp. 682–703). Hoboken, NJ: Wiley.Google Scholar
  58. Lam, K. S. L., Bodfish, J. W., & Piven, J. (2008). Evidence for three subtypes of repetitive behaviour in autism that differ in familiality and association with other symptoms. Journal of Child Psychology and Psychiatry, 49, 1193–1200.PubMedCrossRefGoogle Scholar
  59. Landa, R., Holman, K. C., & Garrett-Mayer, E. (2007). Social and communication development in toddlers with early and later diagnosis of autism spectrum disorders. Archives of General Psychiatry, 64, 853–864.PubMedCrossRefGoogle Scholar
  60. Le Couteur, A., Bailey, A. J., Goode, S., Pickles, A., Robertson, S., Gottesman, I., et al. (1996). A broader phenotype of autism: The clinical spectrum in twins. Journal of Child Psychology and Psychiatry, 37, 785–801.PubMedCrossRefGoogle Scholar
  61. Losh, M., Childress, D., Lam, K., & Piven, J. (2008). Defining key features of the broad autism phenotype: A comparison across parents of multiple- and single-incidence autism families. American Journal of Medical Genetics B: Neuropsychiatric Genetics, 147B, 424–433.CrossRefGoogle Scholar
  62. Lovaas, O. I. (1987). Behavioral treatment and normal educational and intellectual functioning in young autistic children. Journal of Consulting and Clinical Psychology, 55, 3–9.PubMedCrossRefGoogle Scholar
  63. Magnus, P., Irgens, L. M., Haug, K., Nystad, W., Skjaerven, R., Stoltenberg, C., et al. (2006). Cohort profile: The Norwegian mother and child cohort study (MoBa). International Journal of Epidemiology, 35, 1146–1150.PubMedCrossRefGoogle Scholar
  64. Marshall, C. R., Nooer, A., Vincent, J. B., Lionel, A. C., Feuk, L., Skaug, J., et al. (2008). Structural variations of chromosomes in autism spectrum disorder. American Journal of Human Genetics, 82(2), 477–488.PubMedCrossRefGoogle Scholar
  65. McEachin, J. J., Smith, T., & Lovaas, O. I. (1993). Long-term outcome for children with autism who received early intensive behavioral treatment. American Journal of Mental Retardation, 97, 359–372.PubMedGoogle Scholar
  66. Meaney, M. J. (2010). Epigenetics and the biological definition of gene × environment interactions. Child Development, 81, 41–79.PubMedCrossRefGoogle Scholar
  67. Medical Research Council. (2001). MRC review of autism research: Epidemiology and causes. London: MRC.Google Scholar
  68. Mundy, P., & Burnette, C. (2005). Joint attention and neurodevelopmental models of autism. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp. 650–681). Hoboken, NJ: Wiley.Google Scholar
  69. National Research Council. (2001). Educating children with autism. Committee on educational interventions for children with autism. Washington, DC: National Academy Press.Google Scholar
  70. O’Connor, N., & Hermelin, B. (1998). Annotation: Low intelligence and special abilities. Journal of Child Psychology and Psychiatry, 29, 391–396.CrossRefGoogle Scholar
  71. Ozonoff, S., South, M., & Provencal, S. (2005). Executive functions. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp. 606–627). Hoboken, NJ: Wiley.Google Scholar
  72. Palmen, S. J., & van Engeland, H. (2004). Review on structural neuroimaging findings in autism. Journal of Neural Transmission, 111, 903–929.PubMedCrossRefGoogle Scholar
  73. Parr, J. R., Le Couteur, A., Baird, G., Rutter, M., Pickles, A., Fombonne, E., et al. (in press). Early developmental regression in autism spectrum disorder: Evidence from an international multiplex sample. Journal of Autism and Developmental Disorders. doi:10.1007/s10803-010-1055-2
  74. Persico, A., & Bugeron, T. (2006). Searching for ways out of the autism maze: Genetic, epigenetic and environmental clues. Trends in Neuroscience, 29, 349–358.CrossRefGoogle Scholar
  75. Pickles, A., Bolton, P., Macdonald, H., Bailey, A., Le Couteur, A., Sim, C. H., et al. (1995). Latent class analysis of recurrence risks for complex phenotypes with selection and measurement error: A family history study of autism. American Journal of Human Genetics, 57, 717–726.PubMedGoogle Scholar
  76. Pickles, A., Simonoff, E., Conti-Ramsden, G., Falcaro, M., Simkin, Z., Charman, T., et al. (2009). Loss of language in early development of autism and specific language impairment. Journal of Child Psychology and Psychiatry, 50, 843–852.PubMedCrossRefGoogle Scholar
  77. Pickles, A., Starr, E., Kazak, S., Bolton, P., Papanikolaou, K., Bailey, A., et al. (2000). Variable expression of the autism broader phenotype: Findings from extended pedigrees. Journal of Child Psychology and Psychiatry, 41, 491–502.PubMedCrossRefGoogle Scholar
  78. Pinto, D., Pagnamenta, A. T., Klei, L., Anney, R., Merico, D., Regan, R., et al. (2010). Functional impact of global rare copy number variation in autism spectrum disorders. Nature, 466, 368–372.PubMedCrossRefGoogle Scholar
  79. Piven, J., Arndt, S., Bailey, J., Haveramp, S., Andreasen, N. C., & Palmer, P. (1995). An MRI study of brain size in autism. American Journal of Psychiatry, 152, 1145–1149.PubMedGoogle Scholar
  80. Redcay, E., & Courchesne, E. (2005). When is the brain enlarged in autism? A meta-analysis of all brain size reports. Biological Psychiatry, 58, 1–9.PubMedCrossRefGoogle Scholar
  81. Reichenberg, A., Gross, R., Weiser, M., Bresnahan, M., Silverman, J., Harlap, S., et al. (2006). Advancing paternal age and autism. Archives of General Psychiatry, 63, 1026–1032.PubMedCrossRefGoogle Scholar
  82. Ronald, A., Happé, F., & Plomin, R. (2005). The genetic relationship between individual differences in social and nonsocial behaviors characteristic of autism. Developmental Science, 8, 444–458.PubMedCrossRefGoogle Scholar
  83. Rønningen, A., Paltiel, L., Meltzer, H. M., Nordhagen, R., Lie, K. K., Hovengen, R., et al. (2006). The biobank of the Norwegian mother and child cohort study: A resource for the next 100 years. European Journal of Epidemiology, 21, 619–625.PubMedCrossRefGoogle Scholar
  84. Rutter, M. (1970). Autistic children: Infancy to adulthood. Seminars in Psychiatry, 2, 435–450.PubMedGoogle Scholar
  85. Rutter, M. (2003). Roots of mental illness (pp. 11–21). New York: The New York Academy of Sciences.Google Scholar
  86. Rutter, M. (2005a). Incidence of autism spectrum disorders: Changes over time and their meaning. Acta Paediatrica, 94, 2–15.PubMedCrossRefGoogle Scholar
  87. Rutter, M. (2005b). Genetic influences and autism. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp. 425–452). Hoboken, NJ: Wiley.Google Scholar
  88. Rutter, M. (2008). Thimerosal vaccine litigation. Report to US vaccine court 2008.Google Scholar
  89. Rutter, M. (in press). Child psychiatric diagnosis and classification: Concept, findings, challenges & potential. Journal of Child Psychology and Psychiatry.Google Scholar
  90. Rutter, M., & Bailey, A. (1993). Thinking and relationships: Mind and brain. In S. Baron-Cohen, H. Tager-Flusberg, & D. Cohen (Eds.), Understanding other minds: Perspectives from autism (pp. 481–505). New York: Oxford University Press.Google Scholar
  91. Rutter, M., Bailey, A., Bolton, P., & Le Couture, A. (1994). Autism and known medical conditions: Myth and substance. Journal of Child Psychology and Psychiatry, 35, 311–322.PubMedCrossRefGoogle Scholar
  92. Rutter, M., Bailey, A., & Lord, C. (2003). The social communication questionnaire. Manual. Los Angeles, CA: Western Psychological Services.Google Scholar
  93. Rutter, M., & Sonuga-Barke, E. J. (Eds.). (2010). Deprivation-specific psychological patterns: Effects of institutional deprivation. Monographs of the Society for Research in Child Development, 75:1. Serial no. 295.Google Scholar
  94. Scahill, L., & Martin, A. (2005). Psychopharmacology. In F. Volkmar, R. Paul, A. Klin, & D. Cohen (Eds.), Handbook of autism and pervasive developmental disorders (pp. 1102–1117). Hoboken, NJ: Wiley.Google Scholar
  95. Sebat, J., Lakshmi, B., Malhotra, D., Troge, J., Lese-Martin, C., Walsh, T., et al. (2007). Strong association of de novo copy number mutations with autism. Science, 316(58223), 445–449.PubMedCrossRefGoogle Scholar
  96. Stoltenberg, C., Schjølberg, S., Bresnahan, M., Hornig, M., Hirtz, C., et al. (2010). The autism birth cohort: A paradigm for gene–environment-timing research. Molecular Psychiatry, 15, 676–680.PubMedCrossRefGoogle Scholar
  97. Szatmari, P., Bryson, S., Duku, E., Vaccarella, L., Zwaigenbaum, L., Bennett, T., et al. (2009). Similar developmental trajectory in autism and Asperger syndrome: From early childhood to adolescence. Journal of Child Psychology and Psychiatry, 50, 1459–1467.PubMedCrossRefGoogle Scholar
  98. Szatmari, P., Paterson, A. D., Zwaigenbaum, L., Roberts, W., Brian, J., Liu, X.-Q., et al. (2007). Mapping autism risk loci using genetic linkage and chromosomal rearrangements. Nature Genetics, 39(3), 319–328.PubMedCrossRefGoogle Scholar
  99. Treffert, D. A. (2010). The savant syndrome: An extraordinary condition. A synopsis: Past, present, future. In F. Happé & U. Frith (Eds.), Autism and talent (pp. 1–12). New York: Oxford University Press.Google Scholar
  100. Uher, R. (2009). The role of genetic variation in the causation of mental illness: An evolution-informed framework. Molecular Psychiatry, 14, 1072–1082.PubMedCrossRefGoogle Scholar
  101. Volkmar, F. R., & Nelson, D. S. (1990). Seizure disorders in autism. Journal of the American Academy of Child and Adolescent Psychiatry, 29(1), 127–129.PubMedCrossRefGoogle Scholar
  102. Werner, E., & Dawson, G. (2005). Validation of the phenomenon of autistic regression using home videotapes. Archives of General Psychiatry, 62, 889–895.PubMedCrossRefGoogle Scholar
  103. Williams, N. M., Zaharieva, I., Martin, A., Langley, K., Mantripragada, K., Fossdal, R., et al. (2010). Rare chromosomal deletions and duplications in attention-deficit hyperactivity disorder: A genome-wide analysis. Lancet, 376, 1401–1408.PubMedCrossRefGoogle Scholar
  104. Wohl, M., & Gorwood, P. (2007). Paternal ages below or above 35 years old are associated with a different risk of schizophrenia in the offspring. European Psychiatry, 22, 22–26.PubMedCrossRefGoogle Scholar
  105. Woodhouse, W., Bailey, A., Rutter, M., Bolton, P., Baird, G., & Le Couteur, A. (1996). Head circumference in autism and other pervasive developmental disorders. Journal of Child Psychology and Psychiatry, 37, 785–801.CrossRefGoogle Scholar
  106. Yirmiya, N., & Charman, T. (2010). The prodrome of autism: Early behavioural and biological signs, regression, peri- and post-natal development and genetics. Journal of Child Psychology and Psychiatry, 5, 432–458.CrossRefGoogle Scholar
  107. Zwaigenbaum, L., Bryson, S., Rogers, T., Roberts, W., Brian, J., & Szatmari, P. (2005). Behavioral manifestations of autism in the first year of life. International Journal of Developmental Neuroscience, 23, 143–152.PubMedCrossRefGoogle Scholar

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© Springer Science+Business Media, LLC 2011

Authors and Affiliations

  1. 1.MRC Social, Genetic & Developmental Psychiatry Centre, Institute of PsychiatryKing’s College LondonLondonUK

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