Abstract
We investigated correlates of language regression for children diagnosed with autism spectrum disorders (ASD). Using archival data, children diagnosed with ASD (N = 114, M age = 41.4 months) were divided into four groups based on language development (i.e., regression, plateau, general delay, no delay) and compared on developmental, adaptive behavior, symptom severity, and behavioral adjustment variables. Few overall differences emerged between groups, including similar non-language developmental history, equal risk for seizure disorder, and comparable behavioral adjustment. Groups did not differ with respect to autism symptomatology as measured by the Autism Diagnostic Observation Schedule and Autism Diagnostic Interview-Revised. Language plateau was associated with better adaptive social skills as measured by the Vineland Adaptive Behavior Scales. Implications and study limitations are discussed.
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References
American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Washington, DC: American Psychiatric Association. text revision.
Baird, G., Charman, T., Pickles, A., Chandler, S., Loucas, T., Meldrum, D., et al. (2008). Regression, developmental trajectory and associated problems in disorders in the autism spectrum: The SNAP study. Journal of Autism and Developmental Disorders, 38, 1827–1836.
Bernabei, P., Cerquiglini, A., Cortesi, F., & D’Ardia, C. (2007). Regression versus no regression in the autistic disorder: Developmental trajectories. Journal of Autism and Developmental Disorders, 37, 580–588.
Brown, J., & Prelock, P. A. (1995). Brief report: The impact of regression on language development in autism. Journal of Autism and Developmental Disorders, 25, 305–309.
Canitano, R., Luchetti, A., & Zappella, M. (2005). Epilepsy, electroencephalographic abnormalities, and regression in children with autism. Journal of Child Neurology, 20, 27–31.
Centers for Disease Control and Prevention. (2007). Prevalence of autism spectrum disorders-Autism and Developmental Disabilities Monitoring Network, 14 sites, United States, 2002, Surveillance Summaries. Morbidity and Mortality Weekly Report, 56, (No. SS-1).
Cohen, J. (1992). A power primer. Psychological Bulletin, 112, 155–159.
Davidovitch, M., Glick, L., Hotzman, G., Tirosh, E., & Safir, M. P. (2000). Developmental regression in autism: Maternal perception. Journal of Autism and Developmental Disorders, 30, 113–119.
Giannotti, F., Cortesi, F., Cerquiglini, A., Miraglia, D., Vagnoni, C., Sebastianai, T., et al. (2008). An investigation of sleep characteristics, EEG abnormalities and epilepsy in developmentally regressed and non-regressed children with autism. Journal of Autism and Developmental Disorders, 38, 1888–1897.
Goldberg, W. A., Osann, K., Filipek, P. A., Laulhere, T., Jarvis, K., Modahl, D., et al. (2003). Language and other regression: Assessment and timing. Journal of Autism and Developmental Disorders, 33, 607–616.
Hansen, R. L., Ozonoff, S., Krakowiak, P., Angkustsiri, K., Jones, C., Deprey, L. J., et al. (2008). Regression in autism: Prevalence and associated factors in the CHARGE study. Ambulatory Pediatrics, 8, 25–31.
Hrdlicka, M., Komarek, V., Propper, L., Kulisek, R., Zumrova, A., Faladova, L., et al. (2004). Not EEG abnormalities but epilepsy is associated with autistic regression and mental functioning in childhood autism. European Child and Adolescent Psychiatry, 13, 209–213.
Kobayashi, R., & Murata, T. (1998). Setback phenomenon in autism and long-term prognosis. Acta Psychiatrica Scandinavica, 98, 296–303.
Lainhart, J. E., Ozonoff, S., Coon, H., Krasny, L., Dinh, E., Nice, J., et al. (2002). Autism, regression, and the broader autism phenotype. American Journal of Medical Genetics, 113, 231–237.
Landa, R. J., Holman, K. C., & Garrett-Mayer, E. (2007). Social and communication development in toddlers with early and later diagnosis of autism spectrum disorders. Archives of General Psychiatry, 64, 853–864.
Lord, C., Rutter, M., DiLavore, P. C., & Risi, S. (2001). Autism diagnostic observation schedule ADOS manual. Los Angeles: Western Psychological Services.
Lord, C., Rutter, M., & LeCouteur, A. (1994). Autism diagnostic interview-revised: A revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685.
Lord, C., Shulman, C., & DiLavore, P. (2004). Regression and word loss in autistic spectrum disorders. Journal of Child Psychology and Psychiatry, 45, 936–955.
Luyster, R., Richler, J., Risi, S., Hsu, W., Dawson, G., Bernier, R., et al. (2005). Early regression in social communication in autism spectrum disorders: A CPEA study. Developmental Neuropsychology, 27, 311–336.
Meilleur, A.-A. S., & Fombonne, E. (2009). Regression of language and non-language skills in pervasive developmental disorders. Journal of Intellectual Disability Research, 53, 115–124.
Ozonoff, S., Williams, B. J., & Landa, R. (2005). Parental report of the early development of children with regressive autism. Autism, 9, 461–486.
Reynolds, C. R., & Kamphaus, R. W. (1998). Behavior assessment system for children manual. Circle Pines, MN: American Guidance Services, Inc.
Richler, J., Luyster, R., Risi, S., Hsu, W., Dawson, G., Bernier, R., et al. (2006). Is there a “regressive phenotype” of autism spectrum disorder associated with the measles-mumps-rubella vaccine? A CPEA study. Journal of Autism and Developmental Disorders, 36, 299–316.
Rogers, S. J. (2004). Developmental regression in autism spectrum disorders. Mental Retardation and Developmental Disabilities, 10, 139–143.
Siperstein, R., & Volkmar, F. (2004). Brief report: Parental reporting of regression in children with pervasive developmental disorders. Journal of Autism and Developmental Disorders, 34, 731–734.
Sparrow, S. S., Balla, D., & Cichetti, D. (1984). Vineland adaptive behavior scales. Circle Pines, MN: American Guidance Service, Inc.
Tuchman, R. F., & Rapin, I. (1997). Regression in pervasive developmental disorders: Seizures and epileptiform electroencephalogram correlates. Pediatrics, 99, 560–566.
Werner, E., Dawson, G., Munson, J., & Osterling, J. (2005). Variation in early developmental course in autism and its relation with behavioral outcome at 3–4 years of age. Journal of Autism and Developmental Disorders, 35, 337–350.
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This paper is based upon the first author’s doctoral dissertation.
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Jones, L.A., Campbell, J.M. Clinical Characteristics Associated with Language Regression for Children with Autism Spectrum Disorders. J Autism Dev Disord 40, 54–62 (2010). https://doi.org/10.1007/s10803-009-0823-3
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DOI: https://doi.org/10.1007/s10803-009-0823-3