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Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin

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Abstract

Whereas Dysbindin is considered a schizophrenia vulnerability gene, there is no consistency of findings. Phenotype refinement approaches may help to increase the genetic homogeneity and thus reconcile conflicting results. Premorbid adjustment (PMA) has been suggested to aid the phenotypic dissection. Gornick et al. (J Autism Dev Disord 35:831–838, 2005) reported an association between Dysbindin and PMA in US-Caucasian individuals with childhood-onset psychosis. In a sample of 222 adult-onset schizophrenia inpatients from Germany, we could not detect an association between PMA and 36 SNPs in Dysbindin. Our results suggest that genetic variation in Dysbindin may not contribute to the schizophrenia phenotype with an onset beyond childhood. Further studies including even larger samples and more SNPs may be warranted to clarify the relationship between Dysbindin and PMA.

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Acknowledgments

We are greatly indebted to the study participants without whom this research would not be possible. This study was supported by the Deutsche Forschungsgemeinschaft (DFG), the National German Genome Research Network (NGFN) of the Federal Ministry of Education and Research (BMBF), the Alfried Krupp von Bohlen und Halbach Foundation, and NARSAD.

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Authors and Affiliations

  1. Department of Genetic Epidemiology, Central Institute of Mental Health, University of Heidelberg, Mannheim, Germany

    Frederike Schirmbeck, Alexander Georgi, Jana Strohmaier, Christine Schmael, Katja V. Boesshenz, Marcella Rietschel & Thomas G. Schulze

  2. Department of Genomics, Life & Brain Center, University of Bonn, Bonn, Germany

    Thomas W. Mühleisen, Stefan Herms, Per Hoffmann, Markus M. Nöthen & Sven Cichon

  3. Institute of Human Genetics, University of Bonn, Bonn, Germany

    Rami Abou Jamra, Johannes Schumacher, Peter Propping, Markus M. Nöthen & Sven Cichon

  4. Department of Psychiatry and Psychotherapy, University of Bonn, Bonn, Germany

    Wolfgang Maier

  5. Unit on the Genetic Basis of Mood and Anxiety Disorders, National Institute of Mental Health (NIMH), National Institutes of Health (NIH), 35 Convent Drive, Bldg. 35, Rm 1A202, MSC 3719, Bethesda, MD, 20892-3719, USA

    Thomas G. Schulze

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  1. Frederike Schirmbeck
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  2. Alexander Georgi
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Correspondence to Thomas G. Schulze.

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Schirmbeck, F., Georgi, A., Strohmaier, J. et al. Brief Report: No Association Between Premorbid Adjustment in Adult-Onset Schizophrenia and Genetic Variation in Dysbindin. J Autism Dev Disord 38, 1977–1981 (2008). https://doi.org/10.1007/s10803-008-0582-6

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  • DOI: https://doi.org/10.1007/s10803-008-0582-6

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