The Modified Checklist for Autism in Toddlers: A Follow-up Study Investigating the Early Detection of Autism Spectrum Disorders

  • Jamie M. Kleinman
  • Diana L. Robins
  • Pamela E. Ventola
  • Juhi Pandey
  • Hilary C. Boorstein
  • Emma L. Esser
  • Leandra B. Wilson
  • Michael A. Rosenthal
  • Saasha Sutera
  • Alyssa D. Verbalis
  • Marianne Barton
  • Sarah Hodgson
  • James Green
  • Thyde Dumont-Mathieu
  • Fred Volkmar
  • Katarzyna Chawarska
  • Ami Klin
  • Deborah Fein
Original Paper

Abstract

Autism spectrum disorders (ASD) often go undetected in toddlers. The Modified Checklist for Autism in Toddlers (M-CHAT) was used to screen 3,793 children aged 16–30 months from low- and high-risk sources; screen positive cases were diagnostically evaluated. Re-screening was performed on 1,416 children aged 42–54 months. Time1 Positive Predictive Value (PPV) was .36 for the initial screening and .74 for the screening plus follow-up telephone interview; values were similar for Time2 PPV. When separating referral sources, PPV was low for the low-risk sample but acceptable with the follow-up telephone interview. Children with ASD from the low-risk and high-risk samples were highly similar. Results indicate that the M-CHAT continues to be a promising instrument for the early detection of ASD.

Keywords

Autism Early identification Pediatric screening 

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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Jamie M. Kleinman
    • 1
  • Diana L. Robins
    • 2
  • Pamela E. Ventola
    • 3
  • Juhi Pandey
    • 1
  • Hilary C. Boorstein
    • 1
  • Emma L. Esser
    • 1
  • Leandra B. Wilson
    • 1
  • Michael A. Rosenthal
    • 1
  • Saasha Sutera
    • 1
  • Alyssa D. Verbalis
    • 1
  • Marianne Barton
    • 1
  • Sarah Hodgson
    • 1
  • James Green
    • 1
  • Thyde Dumont-Mathieu
    • 1
  • Fred Volkmar
    • 3
  • Katarzyna Chawarska
    • 3
  • Ami Klin
    • 3
  • Deborah Fein
    • 1
  1. 1.Department of PsychologyUniversity of ConnecticutStorrsUSA
  2. 2.Georgia State UniversityAtlantaUSA
  3. 3.Yale University School of MedicineNew HavenUSA

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