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Estimating the Burden of Disease for Autism Spectrum Disorders in Spain in 2003

Abstract

Autism Spectrum Disorders (ASD) are lifelong neurodevelopmental disabilities. Burden of Disease is an indicator that provides important information on health status and outcomes such as premature mortality and disability. In order to estimate the burden of disease of ASD in the Spanish population during 2003, we followed the procedures used in the WHO Global Burden of Disease Study. ASD generated 43,928 Disability Adjusted Life Years (DALY) in Spain in 2003, from which 33,797 were attributable to Autistic Disorder and 10,131 were caused by Asperger’s Disorder and Pervasive Developmental Disorder-Not Otherwise Specified. DALY could be a useful tool for health policy makers for setting health service priorities, allocating available resources effectively and providing a comparable measure of output for early intervention.

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References

  1. American Psychiatric Association. (1994). Diagnostic and Statistical manual of mental disorders, 4th ed (DSM-IV). Washington, DC: American Psychiatric Association.

  2. Barbaresi, W. J., Katusic, S. K., Colligan, R. C., Weaver, A. L., & Jacobsen, S. J. (2005). The incidence of autism in Olmsted County, Minnesota, 1976–97. Archives of Pediatrics & Adolescent Medicine, 159, 37–44.

  3. Bertrand, J., Mars, A., Boyle, C., Bove, F., Yeargin-Allsopp, M., & Decoufle, P. (2001) Prevalence of autism in a United States population: The Brick Township, New Jersey, investigation. Pediatrics, 108, 1155–1161.

  4. Bibby, P., Eikeseth, S., Martin, N. T., Mudford, O. C., & Reeves, D. (2001) Progress and outcomes for children with autism receiving parent-managed intensive interventions. Research in Developmental Disabilities, 22(6), 425–447.

  5. Centers for Disease Control and Prevention (2000). Prevalence of autism in Brick Township, New Jersey, 1998. Atlanta: Centers for Disease Control and Prevention; Community Report. Available at: http://www.cdc.gov/ncbddd/dd/rpttoc.htm.

  6. Chakrabarti, S., & Fombonne, E. (2001): Pervasive developmental disorders in preschool children. Journal American Medical Association, 285, 3093–3099.

  7. Chakrabarti, S., & Fombonne, E. (2005). Pervasive developmental disorders in preschool children: confirmation of high prevalence. American Journal of Psychiatry, 162(6), 1133–1141.

  8. Coale, A., & Guo, G. (1989). Revised regional model life tables at very low levels of mortality. Population Index, 55, 613–643.

  9. Cook, E. H. Jr. (1998). Genetics of autism. Mental Retardation & Developmental Disabilities. Research Reviews, 4, 113–120.

  10. Dawson, G., & Osterling, J. (1997). Early Intervention in autism. In: M. Guralnick (Ed.), The effectiveness of early intervention. (pp. 307–326). Baltimore, MD: Paul H. Brookes Publishing.

  11. Eikeseth, S., Smith, T., Jahr, E., Eldevik, S. (2002) Intensive behavioral treatment at school for 4- to 7-year-old children with autism: a 1-year comparison controlled study. Behavior Modification, 26(1), 49–65.

  12. Fombonne, E. (1999). The epidemiology of autism: a review. Psychological Medicine, 29, 769–786.

  13. Fombonne, E. (2005). Epidemiology of autistic disorder and other pervasive developmental disorders. Journal of Clinical Psychiatry, 66(Suppl 10), 3–8.

  14. Gabriels, R. L., Hill, D. E., Pierce, R. A., & Rogers, S. J. (2001). Predictions of treatment outcomes in young children with autism: a retrospective study. Autism, 5(4), 407–429.

  15. Genova-Maleras, R., Alvarez-Martín, E., & Morant-Ginestar, C. (2005). La carga de enfermedad en España en el año 2000. Las desigualdades de salud entre mujeres y hombres. XXV Conferencia Internacional de Población. Unión Internacional para el Estudio Científico de la población. Tours (Francia) 18–23 de julio de 2005. Available at: http://iussp2005.princeton.edu/abstractViewer.aspx?submissioneId = 52233.

  16. GesMor (2003): Software developed by the International Health Department, Instituto de Salud Carlos III. Supported by the Health Mexican Foundation (FUNSALUD) and the Interamerican Bank for Development. Available from: http://www.funsalud.org.mx/red-jlb/gesmor.htm.

  17. Glasson, E. J. (2002). The Western Australia register for autism spectrum disorders. Journal of paediatrics and child health, 38(3), 321.

  18. Harris, S. L., & Delmolino, L. (2002). Applied behavior analysis: Its application in the treatment of autism and related disorders in young children. Infants and Young Children, 14, 11–17.

  19. Harris, S. L., & Handleman, J. S. (2000) Age and IQ at intake as predictors of placement for young children with autism: a four- to six-year follow-up. Journal of Autism and Developmental Disorders, 30, 137–142.

  20. Hertz-Picciotto, I., Croen, L. A., Hansen, R., Jones, C. R., van de Water, J., Pessah, I. N. (2006) The CHARGE study: an epidemiologic investigation of genetic and environmental factors contributing to autism. Environmental Health Perspectives, 114(7), 1119–1125.

  21. Howlin, P., & Asgharian, A. (1999). The diagnosis of autism and Asperger syndrome: Findings from a survey of 770 families. Developmental Medicine & Child Neurology, 41, 834–839.

  22. Hurth, J., Shaw, E., Izeman, S. G., Whaley, K., & Rogers, S. J. (1999). Areas of agreement about effective practices among programs serving young children with autism spectrum disorders. Infants and Young Children, 12(2), 17–26.

  23. Instituto Nacional de Estadística (INE) (2006). Cifras de Población. Revisión del Padrón Municipal 2003. Available from: http://www.ine.es/inebase/index.html.

  24. Jick, H., Beach, K. J., & Kaye, J. A. (2006). Incidence of autism over time. Epidemiology, 17(1), 120–121.

  25. Murray, C. J. L., & Acharya, A. K. 1997, ‘Understanding DALYs (disability-adjusted life years)’, Journal of Health Economics, 16, 703–730.

  26. Murray , C. J. L., & López, A. D. (Eds.). (1996). The Global Burden of disease: a comprehensive assessment of mortality and disability from diseases, injuries and risk factors in 1990 and projected to 2020. Global Burden of Disease and Injury, Vol. 1. Harvard School of Public Health on behalf of WHO. Cambridge, MA: Harvard University Press, 1996.

  27. Murray, C. J. L., Salomon, J. A., & Mathers, C. (2000). A critical examination of summary measures of population health. Bulletin of the World Health Organization, 78, 981–994.

  28. Murray, C. J. L., Salomon, J. A., Mathers, C. D., & Lopez, A. D. (2002). Summary measures of population health: concepts, ethics, measurement and applications. World Health Organization, Geneva, 2002.

  29. National Autistic Society (2006). Estimated prevalence rates in the UK. Available at: http://www.nas.org.uk/nas/jsp/polopoly.jsp?d=108&a=3527.

  30. Pickett, J. A., Paculdo, D. R., Shavelle, R. M., Strauss, D. J. (2006). 1998–2002 update on causes of death in autism [letter]. Journal of Autism and Developmental Disorders, 36(2), 287–288.

  31. Posada-De la Paz, M., Ferrari-Arroyo, M. J., Touriño, E., & Boada, L. (2005). Investigación epidemiológica en el autismo: una visión integradora. Revista de Neurología, 40(Supl 1), S191–S198.

  32. Powell, J. E., Edwards, A., Edwards, M., Pandit, B. S., Sungum-Paliwal, S. R., & Whitehouse, W. (2000). Changes in the incidence of childhood autism and other autistic spectrum disorders in preschool children from two areas of the West Midlands, UK. Developmental Medicine & Child Neurology, 42, 624–628.

  33. Roberts, J. M. (2003). A review of the research to identify the most effective models of best practice in the management of children with autism spectrum disorders. Sydney: Centre for Developmental Disability Studies.

  34. Rutter, M. (2005). Incidence of autism spectrum disorders: changes over time and their meaning. Acta Paediatrica, 94, 2–15.

  35. Salomon, J. A., & Murray, C. J. (2004). A multi-method approach to measuring health-state valuations. Health Economics, 13(3), 281–290.

  36. Sallows, G. O., & Graupner, T. D. (2005). Intensive behavioral treatment for children with autism: Four-year outcome and predictors. American Journal of Mental Retardation, 110(6), 417–438.

  37. Shavelle, R. M., Strauss, D. (1998) Comparative mortality of persons with autism in California, 1980–1996. Journal of Insurance Medicine, 30(4), 220–225.

  38. Shavelle, R. M., Strauss, D. J., & Pickett, J. (2001). Causes of death in autism. Journal of Autism and Developmental Disorders, 31(6), 569–576.

  39. Shavelle, R. M., Strauss, D. J., Day, S. M. (2003) Comparative mortality of persons with mental retardation in California 1980–1999. Journal of Insurance Medicine, 35(1), 5–8.

  40. Smith, T. (1999). Outcome of early intervention for children with autism. Clinical Psychology: Science and Practice, 6, 33–49.

  41. Stokstad, E. (2001). Development. New hints into the biological basis of autism. Science, 294, 34–37.

  42. Victorian Burden of Disease Study (1999). Morbidity. Public Health Division. Victorian Government Department of Human Services. Melbourne, Victoria 1999. Available at: http://www.health.vic.gov.au/healthstatus/bod/bod_vic.htm.

  43. Victorian Burden of Disease Study (2005). Mortality and morbidity in 2001. Public Health Group. Victorian Government Department of Human Services. Melbourne, Victoria 2005. Available at: http://www.health.vic.gov.au/healthstatus/bod/bod_vic.htm.

  44. Volkmar, F. R. (1998). Autism and pervasive developmental disorders. Cambridge: Cambridge University Press.

  45. Williams, K., Glasson, E. J., Wray, J., Tuck, M., Helmer, M., Bower, C. I., & Mellis, C. M. (2005). Incidence of autism spectrum disorders in children in two Australian states. Med J Aust, 182(3), 108–111.

  46. Wing, L., & Potter, D. (2002). The epidemiology of autistic spectrum disorders: is the prevalence rising? Mental Retardation and Developmental Disabilities Research Reviews, 8, 151–161.

  47. World Health Organization (WHO). (1993). International statistical classification of diseases and related health problems, 10th revision, ICD-10 (Vols 1–3). Geneva: World Health Organization.

  48. World Health Organization (2001). Global burden of disease estimates. GBD 2001 Estimates by Sub-Region. Available at: http://www.who.int/whosis/burden.

  49. World Health Organization (2006). Disability Adjusted Life Years (DALY). Available at: http://www.who.int/healthinfo/boddaly/en/index.html.

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Acknowledgments

The authors wish to thank Elena Álvarez, from the International Health Department, Instituto de Salud Carlos III, Consuelo Morant, from the Regional Mental Health Co-ordination Office, Madrid Autonomous Region, Spain and Ricard Gènova from the Institute of Public Health, Madrid Autonomous Region, Spain for their expert opinion on the burden of diseases subject. The study was financed by the RETICS programme at Instituto de Salud Carlos III, Grants n.G03/123. REpIER (Epidemiology Research Network for Rare Diseases) and C03/05. INERGEN (National Institute of Genetic Rare Diseases).

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Correspondence to Manuel Posada.

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Sánchez-Valle, E., Posada, M., Villaverde-Hueso, A. et al. Estimating the Burden of Disease for Autism Spectrum Disorders in Spain in 2003. J Autism Dev Disord 38, 288–296 (2008) doi:10.1007/s10803-007-0393-1

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Keywords

  • Pervasive developmental disorders
  • Autistic spectrum disorders
  • Burden of disease
  • Disability adjusted life years
  • DALY
  • Epidemiology