The Broad Autism Phenotype Questionnaire
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The broad autism phenotype (BAP) is a set of personality and language characteristics that reflect the phenotypic expression of the genetic liability to autism, in non-autistic relatives of autistic individuals. These characteristics are milder but qualitatively similar to the defining features of autism. A new instrument designed to measure the BAP in adults, the Broad Autism Phenotype Questionnaire (BAPQ), was administered to 86 parents of autistic individuals and 64 community control parents. Sensitivity and specificity of the BAPQ for detecting the BAP were high (>70%). Parents of children with autism had significantly higher scores on all three subscales: aloof personality, rigid personality, and pragmatic language. This instrument provides a valid and efficient measure for characterizing the BAP.
KeywordsAutism Broad autism phenotype Assessment
This research was supported by NIH grants U54 MH66418-02 (JP) and NICHD P30 HD03110. The authors gratefully acknowledge the contributions of Patrick Thompson, Karen Stone, Ellen Cohen, Elizabeth Ashley, and Debra Childress.
- American Psychiatric Association (1994). Diagnostic and statistical manual of mental disorders (DSM-IV) (4th ed). Washington, DC: American Psychiatric Association.Google Scholar
- Baron-Cohen, S., Wheelwright, S., Skinner, R., Martin, J., & Clubley, E. (2001). The Autism-Spectrum quotient (AQ): Evidence from Asperger syndrome/high-functioning autism, males and females, scientists and mathematicians. Journal of Autism and Developmental Disorders, 31, 5–17.PubMedCrossRefGoogle Scholar
- Bishop, D. V. M., Mayberry, M., Maley, A., Wong, D., Hill, W., & Hallmayer, J. (2004). Using self-report to identify the broad phenotype in parents of children with autistic spectrum disorders: A study using the Autism-Spectrum quotient. Journal of Child Psychology and Psychiatry, 45, 1431–1436.PubMedCrossRefGoogle Scholar
- Bradford, Y., Haines, J., Hutcheson, H., Gardiner, M., Braun, T., Sheffield, V., Cassavant, T., Huang, W., Wang, K., Vieland, V., Folstein, S., Santangelo, S., & Piven, J. (2001). Incorporating language phenotypes strengthens evidence of linkage to autism. American Journal of Medical Genetics-Neuropsychiatric Genetics, 105, 539–547.PubMedCrossRefGoogle Scholar
- Constantino, J. N. (2002). The social responsiveness scale. Los Angeles, CA: Western Psychological Services.Google Scholar
- Kanner, L. (1943). Autistic disturbances of affective content. Nervous Child, 2, 217–250.Google Scholar
- Landa, R., Piven, J., Wzorek, M. M., Gayle, J. O., Chase, G. A., Folstein, S. E. (1992). Social language usage in parents of autistic individuals. Psychological Medicine, 46, 245–254.Google Scholar
- Lord, C., Rutter, M., DiLavore, P., & Risi, S. (2006). Autism diagnostic observation schedule. San Antonio, TX: Western Psychological Services.Google Scholar
- Losh, M., & Piven, J. (2006). Social cognition and the broad autism phenotype: Identifying genetically meaningful phenotypes. Journal of Child Psychology and Psychiatry. In press.Google Scholar
- Sung, Y. J., Dawson, G., Munson, J., Estes, A., Schellenberg, G. D., & Wijsman, E. M. (2005). Genetic investigation of quantitative traits related to autism: Use of multivariate polygenic models with ascertainment adjustment. American Journal of Human Genetics, 76, 68–81.PubMedCrossRefGoogle Scholar