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The Gluten-Free, Casein-Free Diet In Autism: Results of A Preliminary Double Blind Clinical Trial

Abstract

This study tested the efficacy of a gluten-free and casein-free (GFCF) diet in treating autism using a randomized, double blind repeated measures crossover design. The sample included 15 children aged 2–16 years with autism spectrum disorder. Data on autistic symptoms and urinary peptide levels were collected in the subjects’ homes over the 12 weeks that they were on the diet. Group data indicated no statistically significant findings even though several parents reported improvement in their children. Although preliminary, this study demonstrates how a controlled clinical trial of the GFCF diet can be conducted, and suggests directions for future research.

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ACKNOWLEDGMENTS

This work was supported by the University of Florida’s College of Nursing Biobehavioral NINR-funded research grant P20 NR 07791-03 and GCRC grant M01RR00082 from the National Institute of Research Resources, National Institutes of Health.

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Correspondence to Jennifer Harrison Elder.

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Elder, J.H., Shankar, M., Shuster, J. et al. The Gluten-Free, Casein-Free Diet In Autism: Results of A Preliminary Double Blind Clinical Trial. J Autism Dev Disord 36, 413–420 (2006). https://doi.org/10.1007/s10803-006-0079-0

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  • DOI: https://doi.org/10.1007/s10803-006-0079-0

Keywords

  • Autism
  • diet
  • gluten
  • casein
  • GFCF diet