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Data-Driven Methods for Predicting ADHD Diagnosis and Related Impairment: The Potential of a Machine Learning Approach

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Abstract

Current diagnostic criteria for ADHD include several symptoms that highly overlap in conceptual meaning and interpretation. Additionally, inadequate sensitivity and specificity of current screening tools have hampered clinicians’ ability to identify those at risk for related outcomes. Using machine learning techniques, the current study aimed to propose a novel algorithm incorporating key ADHD symptoms to predict concurrent and future (i.e., five years later) ADHD diagnosis and related impairment levels. Participants were 399 children with and without ADHD; multiple informant measures of ADHD symptoms, global impairment, academic performance, and social skills were included as part of an accelerated longitudinal design. Results suggested eight symptoms as most important in predicting impairment outcomes five years later: (1) Has difficulty sustaining attention in tasks or play activities, (2) Does not follow through on instructions and fails to finish work, (3) Has difficulty organizing tasks and activities, (4) Avoids tasks (e.g., schoolwork, homework) that require sustained mental effort, (5) Is often easily distracted, (6) Is often forgetful in daily activities, (7) Fidgets with hands or feet or squirms in seat, and (8) Interrupts/intrudes on others. The algorithm comprising this abbreviated list of symptoms performed just as well as or significantly better than one comprising all 18 symptoms in predicting future global impairment and academic performance, but not social skills. It also predicted concurrent and future ADHD diagnosis with 81–93% accuracy. Continued development of screening tools will be key to ensuring access to clinical services for youth at risk for ADHD.

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Acknowledgements

The authors thank all participants for making this work possible. The data that support the findings of this study are available from the corresponding author upon reasonable request. All authors contributed to the paper’s conception, drafting, data analysis, and approved the final product.

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Correspondence to Patrick K. Goh.

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The authors have no conflicts of interest to disclose. Support was provided by NIH R37-MH-59105 and R01-MH-119119.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee (Research Integrity Office Institutional Review Board; Protocol #4817) and with the 1864 Helsinki declaration and its later amendments or comparable ethical standards.

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Informed consent was obtained from all individual participants included in the study.

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Goh, P.K., Elkins, A.R., Bansal, P.S. et al. Data-Driven Methods for Predicting ADHD Diagnosis and Related Impairment: The Potential of a Machine Learning Approach. Res Child Adolesc Psychopathol 51, 679–691 (2023). https://doi.org/10.1007/s10802-023-01022-7

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  • DOI: https://doi.org/10.1007/s10802-023-01022-7

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