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Journal of Abnormal Child Psychology

, Volume 44, Issue 4, pp 757–769 | Cite as

Temperament and its Association with Autism Symptoms in a High-risk Population

  • Nancy GaronEmail author
  • Lonnie Zwaigenbaum
  • Susan Bryson
  • Isabel M. Smith
  • Jessica Brian
  • Caroline Roncadin
  • Tracy Vaillancourt
  • Vickie Armstrong
  • Lori-Ann R. Sacrey
  • Wendy Roberts
Article

Abstract

Temperament was investigated in a group of high-risk infants (N = 383; 45 % girls) who had an older sibling with autism spectrum disorder (ASD), and in community control infants (N = 162; 46 % girls) with no family history of ASD (low-risk). The infants were assessed at age 12 months using the Infant Behavior Questionnaire, and at 24 months using the Toddler Behavior Assessment Questionnaire. At 36 months, an independent blind diagnostic assessment for ASD was conducted using the Autism Diagnostic Interview-Revised (ADI-R) and the Autism Diagnostic Observation Schedule (ADOS). The results indicate not only differences in temperament traits between the high- and low-risk groups, but also differences in the structure of higher-order temperament factors. The results support the importance of early reactive temperament in the development of Effortful Control in the high-risk sample. Furthermore, Effortful Control at 24 months appears to play a critical role in predicting later ASD symptoms (at 36 months). Taken together, these findings support the use of early temperament as an endophenotype for ASD.

Keywords

Autism spectrum disorder Temperament Endophenotype Regulation 

Notes

This research was supported in part by grants from the Canadian Institutes of Health Research, Autism Speaks Canada, and NeuroDevNet. Dr. Zwaigenbaum was supported by the Stollery Children’s Hospital Foundation Chair in Autism Research. Drs. Bryson and Smith were supported by the Joan and Jack Craig Chair in Autism Research, Dr. Szatmari was supported by the Chedoke Health Chair in Child Psychiatry, and Dr. Vaillancourt was supported by a Canada Research Chair in Children’s Mental Health and Violence Protection. We also like to thank the children and families who have participated in this project.

Conflict of interest

The authors have no conflicts of interest.

References

  1. Adamek, L., Nichols, S., Tetenbaum, S. P., Bregman, J., Ponzio, C. A., & Carr, E. G. (2011). Individual temperament and problem behavior in children with autism spectrum disorders. Focus on Autism and Other Developmental Disabilities, 26, 173–183. doi: 10.1177/1088357611405041.CrossRefGoogle Scholar
  2. American Psychiatric Association. (2000). Diagnostic and statistical manual of mental disorders (4th ed.). Washington: American Psychiatric Association.Google Scholar
  3. American Psychiatric Association. (2013). Diagnostic and statistical manual of mental disorders (5th ed.). Washington: American Psychiatric Association.Google Scholar
  4. Anckarsäter, H., Stahlberg, O., Larson, T., Hakansson, C., Jutblad, S., Niklasson, L., & Rastam, M. (2006). The impact of ADHD and autism spectrum disorders on temperament, character, and personality development. The American Journal of Psychiatry, 163, 1239–1244. doi: 10.1176/appi.ajp.163.7.1239.CrossRefPubMedGoogle Scholar
  5. Arbuckle, J. L. (2006). Amos (version 7.0) [computer program]. Chicago: SPSS.Google Scholar
  6. Benjamini, Y., & Hochberg, Y. (1995). Controlling the false discovery rate: a practical and powerful approach to multiple testing. Journal of the Royal Statistical Society: Series B, 57, 289–300.Google Scholar
  7. Bradley, E. A., & Isaacs, B. J. (2006). Inattention, hyperactivity, and impulsivity in teenagers with intellectual disabilities, with and without autism. The Canadian Journal of Psychiatry / La Revue Canadienne de Psychiatrie, 51, 598–606.Google Scholar
  8. Brock, M. E., Freuler, A. A., Baranek, G. T., Watson, L. R., Poe, M. D., & Sabatino, A. A. (2012). Temperament and sensory features of children with autism. Journal of Autism and Developmental Disorders, 42, 2271–2284. doi: 10.1007/s10803-012-1472-5.CrossRefPubMedPubMedCentralGoogle Scholar
  9. Bryson, S. E., Zwaigenbaum, L., Brian, J., Roberts, W., Szatmari, P., Rombough, V., & McDermott, C. (2007). A prospective case series of high-risk infants who developed autism. Journal of Autism and Developmental Disorders, 37, 12–24. doi: 10.1007/s10803-006-0328-2.CrossRefPubMedGoogle Scholar
  10. Capps, L., Kasari, C., Yirmiya, N., & Sigman, M. (1993). Parental perception of emotional expressiveness in children with autism. Journal of Consulting and Clinical Psychology, 61, 475–484. doi: 10.1037/0022-006X.61.3.475.CrossRefPubMedGoogle Scholar
  11. Chen, F. F. (2007). Sensitivity of goodness of fit indexes to lack of measurement invariance. Structural Equation Modeling, 14, 464–504. doi: 10.1080/1070551070130183410.1080/107055107013018342007-12387-005.CrossRefGoogle Scholar
  12. Chess, S., & Thomas, A. (1990). The New York longitudinal study (NYLS): the young adult periods. The Canadian Journal of Psychiatry / La Revue Canadienne De Psychiatrie, 35, 557–561.Google Scholar
  13. Cheung, G. W., & Rensvold, R. B. (2002). Evaluating goodness-of-fit indexes for testing measurement invariance. Structural Equation Modeling, 9, 233–255.CrossRefGoogle Scholar
  14. Clifford, S. M., Hudry, K., Elsabbagh, M., Charman, T., & Johnson, M. H. (2013). Temperament in the first 2 years of life in infants at high-risk for autism spectrum disorders. Journal of Autism and Developmental Disorders, 43, 673–686. doi: 10.1007/s10803-012-1612-y.CrossRefPubMedGoogle Scholar
  15. Curran, P. J., West, S. G., & Finch, J. F. (1996). The robustness of test statistics to nonnormality and specification error in confirmatory factor analysis. Psychological Methods, 1, 16–29. doi: 10.1037/1082-989X.1.1.16.CrossRefGoogle Scholar
  16. del Rosario, M., Gillespie-Lynch, K., Johnson, S., Sigman, M., & Hutman, T. (2014). Parent-reported temperament trajectories among infant siblings of children with autism. Journal of Autism and Developmental Disorders, 44, 381–393. doi: 10.1007/s10803-013-1876-x.CrossRefPubMedPubMedCentralGoogle Scholar
  17. DeYoung, C. G. (2006). Higher-order factors of the Big five in a multi-informant sample. Journal of Personality and Social Psychology, 91, 1138–1151. doi: 10.1037/0022-3514.91.6.1138.CrossRefPubMedGoogle Scholar
  18. DeYoung, C. G. (2014). Cybernetic big five theory. Journal of Research in Personality. doi: 10.1016/j.jrp.2014.07.004.Google Scholar
  19. Doyle, A. E., Faraone, S. V., Seidman, L. J., Willcutt, E. G., Nigg, J. T., Waldman, I. D., & … Biederman, J. (2005). Are endophenotypes based on measures of executive functions useful for molecular genetic studies of ADHD? Journal of Child Psychology and Psychiatry, 46, 778–803.  10.1111/j.1469-7610.2005.01476.x
  20. Eilam-Stock, T., Xu, P., Cao, M., Gu, X., Van Dam, N. T., Anagnostou, E., & … Fan, J. (2014). Abnormal autonomic and associated brain activities during rest in autism spectrum disorder. Brain: A Journal of Neurology, 137, 153–171.  10.1093/brain/awt294
  21. Evans, D. E., & Rothbart, M. K. (2009). A two-factor model of temperament. Personality and Individual Differences, 47, 565–570. doi: 10.1016/j.paid.2009.05.010.CrossRefPubMedPubMedCentralGoogle Scholar
  22. Filliter, J. H., Longard, J., Lawrence, M. A., Zwaigenbaum, L., Brian, J., Garon, N., & … Bryson, S. E. (2015). Positive affect in infant siblings of children diagnosed with autism spectrum disorder. Journal of Abnormal Child Psychology, 43, 567–575.  10.1007/s10802-014-9921-6
  23. Gagne, J. R., Van Hulle, C. A., Aksan, N., Essex, M. J., & Goldsmith, H. (2011). Deriving childhood temperament measures from emotion-eliciting behavioral episodes: scale construction and initial validation. Psychological Assessment, 23, 337–353. doi: 10.1037/a0021746.CrossRefPubMedPubMedCentralGoogle Scholar
  24. Garon, N., Bryson, S., Zwaigenbaum, L., Smith, I.M., Brian, J., Roberts, W., & Szatmari, P. (2009). Temperament and its relationship to autistic symptoms in a high-risk infant sib cohort. Journal of Abnormal Child Psychology, 37, 59–78. doi: 10.1007/s10802-008-9258-0.CrossRefPubMedGoogle Scholar
  25. Goldsmith, H. H. (1996). Toddler behavior assessment questionnaire. Eugene: University of Oregon, Department of Psychiatry.Google Scholar
  26. Goodwin, M. S., Groden, J., Velicer, W. F., Lipsitt, L. P., Baron, M., Hofmann, S. G., & Groden, G. (2006). Cardiovascular arousal in individuals with autism. Focus on Autism and Other Developmental Disabilities, 21, 100–123. doi: 10.1177/10883576060210020101.CrossRefGoogle Scholar
  27. Gottesman, I. I., & Gould, T. D. (2003). The endophenotype concept in psychiatry: etymology and strategic intentions. The American Journal of Psychiatry, 160, 636–645. doi: 10.1176/appi.ajp.160.4.636.CrossRefPubMedGoogle Scholar
  28. Hu, L., & Bentler, P. M. (1999). Cutoff criteria for fit indexes in covariance structure analysis: conventional criteria versus new alternatives. Structural Equation Modeling, 6, 1–55. doi: 10.1080/10705519909540118.CrossRefGoogle Scholar
  29. Kline, R. B. (2011). Principles and practice of structural equation modeling (3rd ed.). New York: Guilford Press.Google Scholar
  30. Komsi, N., Räikkönen, K., Pesonen, A., Heinonen, K., Keskivaara, P., Järvenpää, A., & Strandberg, T. E. (2006). Continuity of temperament from infancy to middle childhood. Infant Behavior & Development, 29, 494–508. doi: 10.1016/j.infbeh.2006.05.002.CrossRefGoogle Scholar
  31. Konstantareas, M., & Stewart, K. (2006). Affect regulation and temperament in children with autism spectrum disorder. Journal of Autism and Developmental Disorders, 36, 143–154. doi: 10.1007/s10803-005-0051-4.CrossRefPubMedGoogle Scholar
  32. Kushki, A., Brian, J., Dupuis, A., & Anagnostou, E. (2014). Functional autonomic nervous system profile in children with ASD. Molecular Autism, 5, 2040–2392.CrossRefGoogle Scholar
  33. Little, T. D. (2013). Longitudinal structural equation modeling. New York: Guilford Press.Google Scholar
  34. Little, T. D., Rhemtulla, M., Gibson, K., & Schoemann, A. M. (2013). Why the items versus parcels controversy needn’t be one. Psychological Methods, 18, 285–300. doi: 10.1037/a0033266.CrossRefPubMedPubMedCentralGoogle Scholar
  35. Lord, C., Rutter, M., & Le Couteur, A. (1994). Autism diagnostic interview—revised: a revised version of a diagnostic interview for caregivers of individuals with possible pervasive developmental disorders. Journal of Autism and Developmental Disorders, 24, 659–685. doi: 10.1007/BF02172145.CrossRefPubMedGoogle Scholar
  36. Lord, C., Risi, S., Lambrecht, L., Cook, E. R., Leventhal, B. L., DiLavore, P. C., & … Rutter, M. (2000). The Autism Diagnostic Observation Schedule—Generic: A standard measure of social and communication deficits associated with the spectrum of autism. Journal of Autism and Developmental Disorders, 30, 205–223.  10.1023/A:1005592401947
  37. Lord, C., Rutter, M., DiLavore, P. C., Risi, S., Gotham, K., & Bishop, S. (2012). Autism diagnostic observation schedule (2nd ed.). Torrance: Western Psychological Services.Google Scholar
  38. Loveland, K. A., Tunali-Kotoski, B., Pearson, D. A., Brelsford, K. A., Ortegon, J., & Chen, R. (1994). Imitation and expression of facial affect in autism. Development and Psychopathology, 6, 433–444. doi: 10.1017/S0954579400006039.CrossRefGoogle Scholar
  39. Mardia, K. V. (1970). Measures of multivariate skewness and kurtosis with applications. Biometrika, 57, 519–530.CrossRefGoogle Scholar
  40. Mullen, E. M. (1995). Mullen scales of early learning - AGS edition. Circle Pines: AGS Publishing.Google Scholar
  41. Nigg, J. T. (2006). Temperament and developmental psychopathology. Journal of Child Psychology and Psychiatry, 47, 395–422. doi: 10.1111/j.1469-7610.2006.01612.x.CrossRefPubMedGoogle Scholar
  42. Osborne, J. W. (2010). Improving your data transformations: applying Box-Cox transformations as a best practice. Practical Assessment, Research, and Evaluation, 15, 1–9.Google Scholar
  43. Ozonoff, S., Garcia, N., Clark, E., & Lainhart, J. E. (2005). MMPI-2 personality profiles of high-functioning adults with autism spectrum disorders. Assessment, 12, 86–95. doi: 10.1177/1073191104273132.CrossRefPubMedGoogle Scholar
  44. Porges, S. W. (2005). The vagus: A mediator of behavioral and visceral features associated with autism. In M. L. Bauman & T. L. Kemper (Eds.), The neurobiology of autism (pp. 65–78). Baltimore: Johns Hopkins University Press.Google Scholar
  45. Posner, M. I., Rothbart, M. K., Sheese, B. E., & Voelker, P. (2012). Control networks and neuromodulators of early development. Developmental Psychology, 48, 827–835. doi: 10.1037/a0025530.CrossRefPubMedPubMedCentralGoogle Scholar
  46. Rainville, P., Bechara, A., Naqvi, N., & Damasio, A. R. (2006). Basic emotions are associated with distinct patterns of cardiorespiratory activity. International Journal of Psychophysiology, 61, 5–18. doi: 10.1016/j.ijpsycho.2005.10.024.CrossRefPubMedGoogle Scholar
  47. Rothbart, M. K. (1981). Measurement of temperament in infancy. Child Development, 52, 569–578. doi: 10.2307/1129176.CrossRefGoogle Scholar
  48. Rothbart, M. K. (2011). Becoming who we are: Temperament and personality in development. New York: Guilford Press.Google Scholar
  49. Rothbart, M. K., & Bates, J. E. (2006). Temperament. In N. Eisenberg, W. Damon, & R. M. Lerner (Eds.), Handbook of child psychology: Vol. 3, social, emotional, and personality development (6th ed., pp. 99–166). Hoboken: Wiley.Google Scholar
  50. Rothbart, M. K., & Posner, M. I. (2006). Temperament, attention, and developmental psychopathology. In D. Cicchetti & D. J. Cohen (Eds.), Developmental psychopathology, Vol 2: Developmental neuroscience (2nd ed., pp. 465–501). Hoboken: Wiley.Google Scholar
  51. Rothbart, M. K., Ellis, L. K., Rueda, M., & Posner, M. I. (2003). Developing mechanisms of temperamental effortful control. Journal of Personality, 71, 1113–1143. doi: 10.1111/1467-6494.7106009.CrossRefPubMedGoogle Scholar
  52. Shiner, R. L., & DeYoung, C. G. (2013). The structure of temperament and personality traits: A developmental perspective. In P. D. Zelazo & P. D. Zelazo (Eds.), The Oxford handbook of developmental psychology (Self and other, Vol. 2, pp. 113–141). New York: Oxford University Press.Google Scholar
  53. Soderstrom, H., Rastam, M., & Gillberg, C. (2002). Temperament and character in adults with Asperger syndrome. Autism, 6(3), 287–297. doi: 10.1177/1362361302006003006.CrossRefPubMedGoogle Scholar
  54. Thayer, J. F., Åhs, F., Fredrikson, M., Sollers, J., & Wager, T. D. (2012). A meta-analysis of heart rate variability and neuroimaging studies: implications for heart rate variability as a marker of stress and health. Neuroscience and Biobehavioral Reviews, 36, 747–756. doi: 10.1016/j.neubiorev.2011.11.009.CrossRefPubMedGoogle Scholar
  55. Wainer, A. L., Ingersoll, B. R., & Hopwood, C. J. (2011). The structure and nature of the broader autism phenotype in a non-clinical sample. Journal of Psychopathology and Behavioral Assessment, 33, 459–469. doi: 10.1007/s10862-011-9259-0.CrossRefGoogle Scholar
  56. Whittle, S., Allen, N. B., Lubman, D. I., & Yücel, M. (2006). The neurobiological basis of temperament: towards a better understanding of psychopathology. Neuroscience and Biobehavioral Reviews, 30, 511–525. doi: 10.1016/j.neubiorev.2005.09.003.CrossRefPubMedGoogle Scholar
  57. Widaman, K. F., & Reise, S. P. (1997). Exploring the measurement invariance of psychological instruments: Applications in the substance use domain. In K. J. Bryant, M. Windle, S. G. West, K. J. Bryant, M. Windle, & S. G. West (Eds.), The science of prevention: Methodological advances from alcohol and substance abuse research (pp. 281–324). Washington: American Psychological Association. doi: 10.1037/10222-009.CrossRefGoogle Scholar
  58. Wiggins, L. D., Reynolds, A., Rice, C. E., Moody, E. J., Bernal, P., Blaskey, L., & … Levy, S. E. (2014). Using standardized diagnostic instruments to classify children with autism in the study to explore early development. Journal of Autism and Developmental Disorders,  10.1007/s10803-014-2287-3
  59. Wing, L., & Gould, J. (1979). Severe impairments of social interaction and associated abnormalities in children: Epidemiology and classification. Journal of Autism and Developmental Disorders, 9, 11–29. doi: 10.1007/BF01531288.CrossRefPubMedGoogle Scholar
  60. Zwaigenbaum, L., Bryson, S. E., Szatmari, P., Brian, J., Smith, I. M., Roberts, W., & … Roncadin, C. (2012). Sex differences in children with autism spectrum disorder identified within a high-risk infant cohort. Journal of Autism and Developmental Disorders, 42, 2585–2596.  10.1007/s10803-012-1515-y

Copyright information

© Springer Science+Business Media New York 2015

Authors and Affiliations

  • Nancy Garon
    • 1
    Email author
  • Lonnie Zwaigenbaum
    • 2
    • 3
  • Susan Bryson
    • 4
  • Isabel M. Smith
    • 4
  • Jessica Brian
    • 5
    • 6
  • Caroline Roncadin
    • 7
  • Tracy Vaillancourt
    • 8
  • Vickie Armstrong
    • 4
  • Lori-Ann R. Sacrey
    • 2
  • Wendy Roberts
    • 6
    • 9
  1. 1.Psychology DepartmentMount Allison UniversitySackvilleCanada
  2. 2.Department of PediatricsUniversity of AlbertaEdmontonCanada
  3. 3.Autism Research CentreGlenrose Rehabilitation HospitalEdmontonCanada
  4. 4.Dalhousie University/IWK Health CentreHalifaxCanada
  5. 5.Bloorview Research InstituteTorontoCanada
  6. 6.University of TorontoTorontoCanada
  7. 7.Kinark Child and Family ServicesMarkhamCanada
  8. 8.University of OttawaOttawaCanada
  9. 9.The Hospital for Sick ChildrenTorontoCanada

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