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Association of Positive and Negative Parenting Behavior with Childhood ADHD: Interactions with Offspring Monoamine Oxidase A (MAO-A) Genotype

Abstract

Relatively little is known about the potential interplay between genetic and environmental influences on attention-deficit/hyperactivity disorder (ADHD), including gene-environment interaction (G×E). There is evidence that parenting behavior interacts with offspring genotype in the development of externalizing problems, but studies have largely focused on explicit maltreatment rather than differentiated measures of parenting behavior, including positive and negative parenting. We tested the interactive effects of the 30-base pair variable number tandem repeat (VNTR) polymorphism of the monoamine oxidase A gene (MAO-A) with positive and negative parenting behavior on parent- and teacher ratings of inattention and hyperactivity symptoms among 150 6–9 year-old boys with and without ADHD. Negative parenting predicted parent and teacher ratings of inattention symptoms, but only among boys with high-activity MAO-A genotype. MAO-A genotype did not moderate the association of positive parenting and parent- and teacher ratings of ADHD. We discuss the potential role of interactive exchanges between parenting behavior and child genotype in the development and persistence of ADHD and related behavior problems.

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Fig. 1

Notes

  1. 1.

    Because racial-ethnic differences have been reported in MAO-A functioning (Sabol et al. 1998), we also report results for Caucasians boys only (n = 70). The results were mostly consistent with our overall model for all boys. The interaction of negative parenting and MAO-A was significant for parent- (B = .63, SE = .24. p < .01) and teacher-rated inattention (B = 3.23, SE = 1.47, p = .04), but not for parent or (B = .18, SE = .22, p = .41) teacher-rated hyperactivity (B = .98, SE = 1.13, p = .40). The association on negative parenting and parent-rated inattention symptoms was only significant for boys with the high-activity genotype (B = .50, SE = .18, p > .01), but not significant for teacher ratings of inattention (B = −.11, SE = .24, p = .66). Furthermore, the association of negative parenting and inattention was not significant for boys with the low activity genotype (parent model: B = −.33, SE = .33, p = .33; teacher model: B = .24, SE = .87, p = .80). For positive parenting, the interaction of MAO-A and positive parenting was not significant for parent-rated (B = −.22, SE = .22, p = .32) or teacher rated inattention (B = −.25, SE = .27, p = .36). Similarly, the interaction of positive parenting and MAO-A was not significant for parent-rated and teacher-rated hyperactivity (B = .11, SE = .19, p = .56 and B = −.35, SE = .21, p = .11, respectively).

References

  1. American Psychiatric Association. (1994). Diagnostic and statistical manual of mental disorders (4th ed.). Washington: Author.

    Google Scholar 

  2. Bakermans-Kranenburg, M. J., & Van IJzendoorn, M. H. (2006). Gene-environment interaction of the dopamine D4 receptor (DRD4) and observed maternal insensitivity predicting externalizing behavior in pre-schoolers. Developmental Psychobiology, 48, 406–409.

    PubMed  Article  Google Scholar 

  3. Bakermans-Kranenburg, M. J., Van IJzendoorn, M. H., Pijlman, F. T. A., Mesman, J., & Juffer, F. (2008). Developmental Psychology, 44, 293–300.

    PubMed  Article  Google Scholar 

  4. Beck, A. T., Steer, R. A., & Brown, G. K. (1996). Beck Depression Inventory-II (BDI-II). San Antonio: Psychological Corporation.

    Google Scholar 

  5. Beitchman, J. H., Mik, H. M., Ehtesham, S., Douglas, L., & Kennedy, J. L. (2004). MAOA and persistent, pervasive childhood aggression. Molecular Psychiatry, 9, 546–547.

    PubMed  Article  Google Scholar 

  6. Belsky, J., & Pluess, M. (2009). Beyond diathesis stress: differential susceptibility to environmental influences. Psychological Bulletin, 135, 885–908.

    PubMed  Article  Google Scholar 

  7. Biederman, J., Kim, J. W., Doyle, A. E., Mick, E., Fagerness, J., Smoller, J. W., et al. (2008). Sexually dimorphic effects of four genes (COMT, SLC6A2, MAOA, SLC6A4) in genetic associations of ADHD: a preliminary study. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147B, 1511–1518.

    Article  Google Scholar 

  8. Brambor, T., Clark, W. R., & Golder, M. (2005). Understanding interaction models: improving empirical analyses. Political Analysis, 13, 1–20.

    Article  Google Scholar 

  9. Buckholtz, J. W., Callicott, J. H., Kolachana, B., Hariri, A. R., Goldberg, T. E., Genderson, M., et al. (2008). Genetic variation in MAOA modulate ventromedial prefrontal circuitry mediating individual differences in human personality. Molecular Psychiatry, 13, 313–324.

    PubMed  Article  Google Scholar 

  10. Burt, S. A., McGrue, M., Krueger, R. F., & Iacono, W. G. (2007). Environmental contributions to adolescent delinquency: a fresh look at shared environment. Journal of Abnormal Child Psychology, 35, 787–800.

    PubMed  Article  Google Scholar 

  11. Carrel, L., & Willard, H. F. (2005). X-inactivation profile reveals extensive variability in X-linked gene expression in females. Nature, 434, 400–404.

    PubMed  Article  Google Scholar 

  12. Cases, O., Seif, I., Grimsby, J., Gaspar, P., Chen, K., Pournin, S., et al. (1995). Aggressive behavior and altered amounts of brain serotonin and norepinephrine in mice lacking MAOA. Science, 268, 1763–1766.

    PubMed  Article  Google Scholar 

  13. Chronis, A. M., Lahey, B., Pelham, W. E., Williams, S. H., Baumann, B. L., Kipp, H., et al. (2007). Maternal depression and early positive parenting predict future conduct problems in young children with attention-deficit/hyperactivity disorder. Developmental Psychology, 43, 70–82.

    PubMed  Article  Google Scholar 

  14. Chronis-Tuscano, A. M., Raggi, V. L., Clarke, T. L., Rooney, M. E., Diaz, Y., & Pian, J. (2008). Associations between maternal attention-deficit/hyperactivity disorder symptoms and parenting. Journal of Abnormal Child Psychology, 36, 1237–1250.

    PubMed  Article  Google Scholar 

  15. Congdon, E., Lesch, K. P., & Canli, T. (2008). Analysis of DRD4 and DAT polymorphisms and behavioral inhibition in healthy adults: implications for impulsivity. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 147, 27–32.

    Article  Google Scholar 

  16. Dadds, M. R., Maujean, A., & Fraser, J. A. (2003). Parenting and conduct problems in children: Australian data and psychometric properties of the Alabama Parenting Questionnaire. Australian Psychologist, 38, 238–241.

    Article  Google Scholar 

  17. Das, M., Bhowmik, A. D., Sinha, S., Chattopadhyay, A., Chaudhuri, K., Singh, M., et al. (2006). MAOA promoter polymorphism and attention deficit hyperactivity disorder (ADHD) in Indian children. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 141B, 637–642.

    Article  Google Scholar 

  18. Davidson, R. J., Putnam, K. M., & Larson, C. L. (2006). Dysfunction in the neural circuit of emotion regulation – A possible prelude to violence. Science, 289, 591–594.

    Article  Google Scholar 

  19. Edwards, A. C., Dodge, K. A., Latendresse, S. J., Lansford, J. E., Bates, J. E., Pettit, G. S., et al. (2010). MAOA-uVNTR and early physical discipline interact to influence delinquent behavior. Journal of Child Psychology and Psychiatry, 51, 679–687.

    PubMed  Article  Google Scholar 

  20. Ellis, B., & Nigg, J. (2009). Parenting practices and attention-deficit/hyperactivity disorder: new findings suggest partial specificity of effects. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 146–154.

    PubMed  Article  Google Scholar 

  21. Evenden, J. L. (1999). Varieties of impulsivity. Psychopharmacology, 146, 348–361.

    PubMed  Article  Google Scholar 

  22. Faraone, S. V., Sergeant, J., Gillberg, C., & Biederman, J. (2003). The worldwide prevalence of ADHD: is it an American condition? World Psychiatry, 2, 104–113.

    PubMed  Google Scholar 

  23. Fowler, J. S., Alia-Klein, N., Kriplani, A., Logan, J., Williams, B., Zhu, W., et al. (2007). Evidence that brain MAOA activity does not correspond to MAOA genotype in healthy male subjects. Biological Psychiatry, 62, 355–358.

    PubMed  Article  Google Scholar 

  24. Frick, P. J. (1991). The Alabama Parenting Questionnaire. University of Alabama.

  25. Frick, P. J., & Dantagnan, A. L. (2005). Predicting the stability of conduct problems in children with and without callous-unemotional traits. Journal of Child and Family Studies, 14, 469–485.

    Article  Google Scholar 

  26. Froehlich, T. E., Lanphear, B. P., Epstein, J. N., Barbaresi, W. J., Katusic, S. K., & Kahn, R. S. (2007). Prevalence, recognition, and treatment of attention-deficit/hyperactivity disorder in a national sample of US children. Archives of Pediatrics and Adolescent Medicine, 161, 857–864.

    PubMed  Article  Google Scholar 

  27. Gabriel, S. B., Schaffner, S. F., Nguyen, H., Moore, J. M., Roy, J., Blumenstiel, B., et al. (2002). The structure of haplotype blocks in the human genome. Science, 296, 2225–2229.

    PubMed  Article  Google Scholar 

  28. Gauderman, W. J. (2002). Sample size requirements for association studies of gene-gene interactions. American Journal of Epidemiology, 155, 478–487.

    PubMed  Article  Google Scholar 

  29. Gizer, I., Ficks, C., & Waldman, I. (2009). Candidate gene studies of ADHD: a meta-analytic review. Human Genetics, 126, 51–90.

    PubMed  Article  Google Scholar 

  30. Hawes, D. J., & Dadds, M. R. (2006). Assessing parenting practices through parent-report and direct observation during parent-training. Journal of Child and Family Studies, 15, 555–568.

    Article  Google Scholar 

  31. Holland, P. C., & Gallagher, M. (1999). Amygdala circuitry in attentional and representational processes. Trends in Cognitive Sciences, 3, 65–73.

    PubMed  Article  Google Scholar 

  32. Hudziak, J. J., Heath, A. C., Madden, P. F., Reich, W., Bucholz, K. K., Slutske, W., et al. (1998). Latent class and factor analysis of DSM-IV ADHD: a twin study of female adolescents. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 848–857.

    PubMed  Article  Google Scholar 

  33. Jaffee, S. R., & Price, T. S. (2007). Gene-environment correlations: a review of the evidence and implications for prevention of mental illness. Molecular Psychiatry, 12, 432–442.

    PubMed  Google Scholar 

  34. Johnston, C., & Mash, E. J. (2001). Families of children with attention-deficit/hyperacitivty disorder: review of recommendations for future research. Clinical Child and Family Psychology Review, 4, 183–207.

    PubMed  Article  Google Scholar 

  35. Kahn, R. S., Khoury, J., Nichols, W. C., & Lanphear, B. P. (2003). Role of dopamine transporter genotype and maternal prenatal smoking in childhood hyperactive-impulsive, inattentive, and oppositional behaviors. Journal of Pediatrics, 143, 104–110.

    PubMed  Article  Google Scholar 

  36. Kato, T., Dong, B., Ishii, K., & Kinemuchi, H. (1986). Brain dialysis: in vivo metabolism of dopamine and serotonin by monoamine oxidase A but not B in the striatum of unrestrained rats. Journal of Neurochemistry, 46, 1277–1282.

    PubMed  Article  Google Scholar 

  37. Kim-Cohen, J., Caspi, A., Taylor, A., Williams, B., Newcombe, R., Craig, I. W., et al. (2006). MAOA, maltreatment, and gene-environment interaction predicting children’s mental health: new evidence and a meta-analysis. Molecular Psychiatry, 11, 903–913.

    PubMed  Article  Google Scholar 

  38. Klive, E., Kurrikoff, T., Maestu, J., & Harro, J. (2010). Effect of alpha2A-adrenoceptor C-1291 g genotype and maltreatment on hyperactivity and inattention in adolescents. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34, 219–224.

    Article  Google Scholar 

  39. Lahey, B. B., Pelham, W. E., Stein, M. A., Loney, J., Trapani, C., Nugent, K., et al. (1998). Validity of DSM-IV attention-deficit/hyperactivity disorder for younger children. Journal of the American Academy of Child and Adolescent Psychiatry, 37, 695–702.

    PubMed  Article  Google Scholar 

  40. Lahey, B. B., Rathouz, P. J., Lee, S. S., Chronis-Tuscano, A., Pelham, W. E., Waldman, I. D., et al. (2011). Interactions between early parenting and a polymorphism of the child’s dopamine transporter gene in predicting future child conduct disorder symptoms. Journal of Abnormal Psychology, 120, 33–45.

    PubMed  Article  Google Scholar 

  41. Langley, K., Fowler, T., Ford, T., Thapar, A. K., van den Bree, M., Harold, G., et al. (2010). Adolescent clinical outcomes for young people with attention-deficit/hyperactivity disorder. The British Journal of Psychiatry, 196, 235–240.

    PubMed  Article  Google Scholar 

  42. Lawson, D. C., Turic, D., Langley, K., Pay, H. M., Govan, C. F., Norton, N., et al. (2003). Association analysis of monoamine oxidase A and attention deficit hyperactivity disorder. American Journal of Medical Genetics Part B, 116, 84–89.

    Google Scholar 

  43. Lee, S. S., Chronis-Tuscano, A., Keenan, K., Pelham, W. E., Loney, J., Van Hulle, C. A., et al. (2010). Association of maternal dopamine transporter genotype with negative parenting: evidence for gene x environment interaction with child disruptive behavior. Molecular Psychiatry, 15, 548–558.

    PubMed  Article  Google Scholar 

  44. Liu, D., Diorio, J., Tannenbaum, B., Caldji, C., Francis, D., Freedman, A., et al. (1997). Maternal care, hippocampal glucocorticoid receptors, and hypothalami-pituitary-adrenal responses to stress. Science, 277, 1659–1662.

    PubMed  Article  Google Scholar 

  45. Luan, J. A., Wong, M. Y., Day, N. E., & Wareham, N. J. (2001). Sample size determination for studies of gene-environment interaction. International Journal of Epidemiology, 30, 1035–1040.

    PubMed  Article  Google Scholar 

  46. Lytton, H. (1990). Child and parent effects in boys’ conduct disorder: a reinterpretation. Developmental Psychology, 26, 683–697.

    Article  Google Scholar 

  47. Manor, I., Tyano, S., Mel, E., Eisenberg, J., Bachner-Melman, R., Kotler, M., et al. (2002). Family-based and association studies of monoamine oxidase A and attention deficit hyperactivity disorder (ADHD: preferential transmission of the long promoter region repeat and its association with impaired performance on a continuous performance test (TOVA). Molecular Psychiatry, 7, 625–632.

    Google Scholar 

  48. Martel, M. M., Nikolas, M., Jernigan, K., Friderici, K., Waldman, I., & Nigg, J. T. (2010). The dopamine receptor D4 gene (DRD4) moderates family environmental effects on ADHD. Journal of Abnormal Psychology, 39, 1–10.

    Google Scholar 

  49. Melnick, S. M., & Hinshaw, S. P. (2000). Emotion regulation and parenting in AD/HD and comparison boys: linkages with social behaviors and peer preference. Journal of Abnormal Child Psychology, 28, 73–86.

    PubMed  Article  Google Scholar 

  50. Meyer-Lindenberg, A., & Weinberger, D. R. (2006). Intermediate phenotypes and genetic mechanisms of psychiatric disorders. Nature Reviews Neuroscience, 7, 818–827.

    PubMed  Article  Google Scholar 

  51. Meyer-Lindenberg, A., Buckholtz, J. W., Kolachana, B., Hariri, A. R., Pezawas, L., Blasi, G., et al. (2006). Neural mechanisms of genetic risk for impulsivity and violence in humans. Proceedings of the National Academy of Sciences, 103, 6269–6274.

    Article  Google Scholar 

  52. Moffitt, T. E. (2005). The new look of behavioral genetics in developmental psychopathology: gene-environment interplay in antisocial behaviors. Psychological Bulletin, 131, 533–554.

    PubMed  Article  Google Scholar 

  53. Molina, B. S., Hinshaw, S. P., Swanson, J. M., Arnold, L. E., Vitiello, B., Jensen, P. S., et al. (2009). The MTA at 8 years: prospective follow-up of children treated for combined-type ADHD in a multisite study. Journal of the American Academy of Child and Adolescent Psychiatry, 48, 484–500.

    PubMed  Article  Google Scholar 

  54. Nigg, J., Nikolas, M., & Burt, S. A. (2010). Measured gene-by-environment interaction in relation to attention-deficit/hyperactivity disorder. Journal of the American Academy of Child and Adolescent Psychiatry, 49, 863–873.

    PubMed  Article  Google Scholar 

  55. Nikolas, M. A., & Burt, S. A. (2010). Genetic and environmental influences on ADHD symptom dimensions of inattention and hyperactivity: a meta-analysis. Journal of Abnormal Psychology, 119, 1–17.

    PubMed  Article  Google Scholar 

  56. Pelham, W. E., Gnagy, E. M., Greenslade, K. E., & Milich, R. (1992). Teacher ratings of DSM-III-R symptoms for the disruptive behavior disorders. Journal of the American Academy of Child and Adolescent Psychiatry, 31, 210–218.

    PubMed  Article  Google Scholar 

  57. Pelham, W. E., Foster, E. M., & Robb, J. A. (2007). The economic impact of attention-deficit/hyperactivity disorder in children and adolescents. Ambulatory Pediatrics, 7, 121–131.

    PubMed  Article  Google Scholar 

  58. Pettit, G. S., Bates, J. E., & Dodge, K. A. (1997). Supportive parenting, ecological context, and children’s adjustment: a seven-year longitudinal study. Child Development, 68, 908–923.

    Google Scholar 

  59. Pfiffner, L. J., McBurnett, K., Rathouz, P. J., & Judice, S. (2005). Family correlates of oppositional and conduct disorder in children with attention deficit/hyperactivity disorder. Journal of Abnormal Child Psychology, 33, 551–563.

    PubMed  Article  Google Scholar 

  60. Pluess, M., Belsky, J., Way, B. M., & Taylor, S. E. (2010). 5-HTTLPR moderates effects of current life events on neuroticism: differential susceptibility to environmental influences. Progress in Neuro-Psychopharmacology and Biological Psychiatry, 34, 1070–1074.

    PubMed  Article  Google Scholar 

  61. Qian, Q. J., Yang, L., Wang, Y. F., Zhang, H. B., Guan, L. L., Chen, Y., et al. (2010). Gene–gene interaction between COMT and MAOA potentially predicts the intelligence of attention-deficit hyperactivity disorder boys in China. Behavior Genetics, 40, 57–365.

    Article  Google Scholar 

  62. Roohi, J., DeVincent, C. J., Hatchwell, E., & Gadow, K. D. (2009). Association of a monoamine oxidase-A gene promoter polymorphism with ADHD and anxiety in boys with autism spectrum disorder. Journal of Autism Developmental Disorders, 39, 67–74.

    Article  Google Scholar 

  63. Royston, P., Altman, D. G., & Sauerbrei, W. (2005). Dichotomizing continuous predictors in multiple regression: a bad idea. Statistics in Medicine, 25, 127–141.

    Article  Google Scholar 

  64. Sabol, S. Z., Hu, S., & Hamer, D. (1998). A functional polymorphism in the monoamine oxidase A gene promoter. Human Genetics, 103, 273–279.

    PubMed  Article  Google Scholar 

  65. Shaffer, D., Fisher, P., Lucas, C. P., Dulcan, M. K., & Schwab-Stone, M. E. (2000). NIMH diagnostic interview schedule for children version IV (NIMH DISC-IV): description, differences from previous versions, and reliability of some common diagnoses. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 28–38.

    PubMed  Article  Google Scholar 

  66. Shaw, P., Lerch, J., Greenstein, D., Sharp, W., Clasen, L., Evans, A., et al. (2006). Longitudinal mapping of cortical thickness and clinical outcome in children and adolescents with attention-deficit/hyperactivity disorder. Archives of General Psychiatry, 63, 540–549.

    PubMed  Article  Google Scholar 

  67. Shelton, K. K., Frick, P. J., & Wootton, J. (1996). Assessment of parenting practices in families of elementary school-age children. Journal of Clinical Child Psychology, 25, 317–329.

    Article  Google Scholar 

  68. Sjoberg, R. L., Nilsson, K. W., Wargelius, H. L., Leppert, J., Lindstrom, L., & Oreland, L. (2007). Adolescent girls and criminal activity: role of MAOA-LPR genotype and psychosocial factors. American Journal of Medical Genetics Part B: Neuropsychiatric Genetics, 144, 159–164.

    Article  Google Scholar 

  69. Spencer, T. J., Adler, L. A., McGough, J. J., Muniz, R., Jiang, H., & Pestreich, L. (2007). Efficacy and safety of dexmethylphenidate extended-release capsules in adults with attention-deficit/hyperactivity disorder. Biological Psychiatry, 61, 1380–1387.

    PubMed  Article  Google Scholar 

  70. Sprich, S., Biederman, J., Crawford, M. H., Mundy, E., & Faraone, S. V. (2000). Adoptive and biological families of children and adolescents with ADHD. Journal of the American Academy of Child and Adolescent Psychiatry, 39, 1432–1437.

    PubMed  Article  Google Scholar 

  71. Swanson, J. M., Kinsbourne, M., Nigg, J., Lanphear, B., Stefanatos, G. A., Volkow, N., et al. (2007). Etiologic subtypes of attention-deficit/hyperactivity disorder: brain imaging, molecular genetic and environmental factors and the dopamine hypothesis. Neuropsychology Review, 17, 39–59.

    PubMed  Article  Google Scholar 

  72. Szyf, M., McGowan, P., & Meaney, M. J. (2007). The social environment and the epigenome. Environmental and Molecular Mutagenesis, 49, 46–60.

    Article  Google Scholar 

  73. Thomas, D. (2010). Methods for investigation gene-environment interactions in candidate pathway and genome-wide association studies. Annual Review of Public Health, 31, 21–36.

    PubMed  Article  Google Scholar 

  74. Vanyukov, M. M., Maher, B. S., Devlin, B., Kirillova, G. P., Kirisci, L., Yu, L. M., et al. (2008). The MAOA promoter polymorphism, disruptive behavior disorders, and early onset substance use disorders: gene-environment interaction. Psychiatric Genetics, 17, 323–332.

    Article  Google Scholar 

  75. Wakschlag, L. S., Kistner, E. O., Pine, D. S., Biesecker, G., Pickett, K. E., Skol, A. D., et al. (2010). Interaction of prenatal exposure to cigarettes and MAOA genotype in pathways to youth antisocial behavior. Molecular Psychiatry, 15, 928–937.

    PubMed  Article  Google Scholar 

  76. Wells, K. C., Epstein, J. N., Hinshaw, S. P., Conners, C. K., Klaric, J., Abikoff, H. B., et al. (2000). Parenting and family stress treatment outcomes in attention deficit hyperactivity disorder (ADHD): an empirical analysis in the MTA study. Journal of Abnormal Child Psychology, 28, 543–533.

    PubMed  Article  Google Scholar 

  77. Widom, C. S., & Brzustowicz, L. M. (2006). MAOA and the “cycle of violence”: childhood abuse and neglect, MAO-A genotype, and the risk for violent and antisocial behavior. Biological Psychiatry, 60, 684–689.

    PubMed  Article  Google Scholar 

  78. Willcutt, E. G., Doyle, A. E., Nigg, J. T., Faraone, S. V., & Pennington, B. F. (2005). Validity of the executive function theory of attention-deficit/hyperactivity disorder: a meta-analytic review. Biological Psychiatry, 57, 1336–1346.

    PubMed  Article  Google Scholar 

  79. Xu, X., Brookes, K., Chen, C. K., Huang, Y. S., Wu, Y., & Asherson, P. (2007). Association study between the monoamine oxidase A gene and attention deficit hyperactivity disorder in Taiwanese samples. BMC Psychiatry, 7, 7–10.

    Article  Google Scholar 

  80. Zhu, J., Chen, Y., Lai, J., Dang, Y., Yan, C., Xu, M., et al. (2010). Dopamine D3 receptor regulates basal but not amphetamine-induced changes in pain sensitivity in mice. Neuroscience Letters, 477, 134–137.

    PubMed  Article  Google Scholar 

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Correspondence to Steve S. Lee.

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This work was partially supported by the Consortium of Neuropsychiatric Phenomics (CNP) (NIH Roadmap for Medical Research grant UL1-DE019580, RL1DA024853) and NIH Grant 1R03AA020186-01 to Steve S. Lee.

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Li, J.J., Lee, S.S. Association of Positive and Negative Parenting Behavior with Childhood ADHD: Interactions with Offspring Monoamine Oxidase A (MAO-A) Genotype. J Abnorm Child Psychol 40, 165–175 (2012). https://doi.org/10.1007/s10802-011-9553-z

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Keywords

  • Parenting
  • ADHD
  • Gene-environment interaction
  • MAO-A