Journal of Abnormal Child Psychology

, Volume 36, Issue 3, pp 433–444 | Cite as

Common Genetic and Environmental Influences on Major Depressive Disorder and Conduct Disorder

  • Anjali Subbarao
  • Soo Hyun RheeEmail author
  • Susan E. Young
  • Marissa A. Ehringer
  • Robin P. Corley
  • John K. Hewitt


The evidence for common genetic and environmental influences on conduct disorder (CD) and major depressive disorder (MDD) in adolescents was examined. A sample of 570 monozygotic twin pairs, 592 dizygotic twin pairs, and 426 non-twin siblings, aged 12–18 years, was recruited from the Colorado Twin Registry. For the past year data, there was a significant correlation between the genetic influences on MDD and CD and, for the lifetime data, there was a significant correlation between the genetic influences on MDD and CD, and a significant correlation between the nonshared environmental influences on MDD and CD. Our results suggest that some genetic factors will increase an individual’s vulnerability to both MDD and CD in adolescence.


Major depressive disorder Conduct disorder Comorbidity 



This work was supported by National Institutes of Health Grants MH43899, MH16880, HD10333, DA11015, and DA13956. We thank Michael C. Stallings and Sally-Ann Rhea for helpful comments regarding the manuscript.


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Copyright information

© Springer Science+Business Media, LLC 2007

Authors and Affiliations

  • Anjali Subbarao
    • 1
  • Soo Hyun Rhee
    • 1
    • 2
    Email author
  • Susan E. Young
    • 2
  • Marissa A. Ehringer
    • 2
    • 3
  • Robin P. Corley
    • 2
  • John K. Hewitt
    • 1
    • 2
  1. 1.Department of PsychologyUniversity of ColoradoBoulderUSA
  2. 2.Institute for Behavioral GeneticsUniversity of ColoradoBoulderUSA
  3. 3.Department of Integrative PhysiologyUniversity of ColoradoBoulderUSA

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