Abstract
Voltammetric methods have been used for the determination of chlorphenoxamine hydrochloride (Ch-HCl) in raw material and in its pharmaceutical preparations (Allergex and Allergex caffeine tablet). It was found that Ch-HCl gives a characteristic cyclic voltammetric (CV) and differential pulse voltammetric (DPV) peak in acetonitrile using platinum and glassy carbon working electrodes. The I p of the DPV peak increases linearly within the concentration range from 4.5 × 10−4 to 1.0 × 10−2 mol L−1 of the investigated drug. The concentration of Ch-HCl in raw drug material and in its pharmaceutical preparations was determined using the standard addition method, Randles–Sevcik equation and indirectly via its complexation with sodium tetraphenylborate (NaTPB). The obtained over all average recoveries were 101.44 and 100.49% with SD 0.45 and 0.38 (n = 4) for platinum and glassy carbon electrodes, respectively. The effect of scan rate, sample concentration, and supporting electrolyte on the I p and E p was also investigated.
Similar content being viewed by others
References
Kelani KM (2005) J AOAC Int 88(4):1126
Dinc E, Palabiyik IM, Ustundag O, Yurtsever F, Onur F (2002) J Pharm Biomed Anal 28(3–4):591
Ayad M, Saleh H, El-Bolkiny M, El-Henawee M (1993) Anal Lett 26(5):913
Barary MH, Wahbi AM (1991) Drug Dev Ind Pharm 17(3):457
El-Henawee MM, Mohamed HS, El-Bolkiny N, Ayad MM (1990) Spectrosc Lett 23(3):273
Amine AS, El-Henawee MM (1995) Mikrochim Acta 118(3–4):177
Metrohm Application Bulletin (2001) Technical report 263/1e: 11
Bebawy LI, El-Kousy MN (1999) J Pharm Biomed Anal 20(4):663
Goeneches S, Ruecker G, Brzezinka H, Hoffmann G, Neugebauer M, Pyzik T (1987) Arzneim Forsch 37(7):854
Zareh MM, Teleb SM, Ahmed ES (2002) Anal Lett 35:17
Isaa YM, Amin AS (1996) Analusis 24:139
Temizer A, Ozaltin N (1986) J AOAC Int 69(2):192
Abdel-Ghani NT, El-Ries MA, El-Shall MA (2007) Anal Sci 23:1053
Svancara I, Ogorevc B, Hocevar SB, Vytras K (2002) Anal Sci 18:301
De Btono SF, Garcia AA, Arranz Valentin JF (1999) J Pharm Biomed Anal 20:621
Ewing GW (1995) Instrumental methods of chemical analysis, 5th edn. Lippincott/Raven, Philadelphia
West DM, Holler FJ, Grouch SR (2004) Fundamental of analytical chemistry, 8th edn. Thomson-Brooks/Cole, USA
Abdel-Ghani NT, Shoukry AF, Hussein SH (2002) J Pharm Biomed Anal 30:601
Issa YM, Shoukry AF, El-Nashar RM (2001) J Pharm Biomed Anal 26:379
Pickering WF (1971) Modern analytical chemistry. Marcel Dekker, New York
Nesmaeyanov AN, Nesmaeyanov NA (1986) Fundamental of organic chemistry, 3rd edn. MIR Publisher, Moscow
David K, Gosser JR (1993) Cyclic voltammetry simulation and analysis of reaction mechanisms. VCH Publishers, UK
Miller JC, Miller JN (1993) Statistics for analytical chemistry, 4th edn. Ellis Horwood Ltd, New York
Christian GD (1994) Analytical chemistry, 5th edn. Wiley, USA
Author information
Authors and Affiliations
Corresponding author
Rights and permissions
About this article
Cite this article
Abdel-Ghani, N.T., Abu-Elenien, G.M. & Hussein, S.H. Differential pulse voltammetric determination of chlorphenoxamine hydrochloride and its pharmaceutical preparations using platinum and glassy carbon electrodes. J Appl Electrochem 40, 499–505 (2010). https://doi.org/10.1007/s10800-009-0021-1
Received:
Accepted:
Published:
Issue Date:
DOI: https://doi.org/10.1007/s10800-009-0021-1