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Evaluation of choroidal thickness and choroidal vascularity index in patients with Crimean-Congo hemorrhagic fever

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Abstract

Purpose

This study aimed to compare choroidal thickness parameters between patients diagnosed with Crimean–Congo hemorrhagic fever (CCHF) and healthy individuals using spectral domain optical coherence tomography.

Methods

The right eyes of 27 individuals diagnosed with CCHF and 27 healthy subjects were included in this study. CCHF cases were assessed based on a history of tick bites and hospitalization. Choroidal thickness was measured using enhanced depth imaging optical coherence tomography. Measurements of choroidal thickness were taken at 5 different points, including the subfoveal quadrant and the fovea up to 2000 μm with 1000 μm intervals in the temporal and nasal quadrants. Choroidal vascular index (CVI) was calculated as the ratio of luminal area (LA) to total choroidal area (TCA) at the macula's total area and at 1500 μm from the center (CVI and CVI1500).

Results

Choroidal thickness in the CCHF group was found to be thicker in each quadrant compared to the control group, with the subfoveal and nasal quadrants showing significantly greater thickness. TCA, stromal area, and LA were significantly higher in the CCHF group, while no significant difference was observed in CVI and CVI1500.

Conclusion

The findings of this study suggest that CCHF disease may have an impact on the choroidal structure.

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Funding

No financial support was received for this submission.

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Authors and Affiliations

  1. Department of Ophthalmology, Medical Faculty, Tokat Gaziosmanpaşa University, Tokat, Turkey

    Şerife Gülhan Konuk & Raşit Kılıç

  2. Department of Infectious Diseases and Clinical Microbiology, Medical Faculty, Tokat Gaziosmanpaşa University, Tokat, Turkey

    Emine Türkoğlu Yılmaz

  3. Karaman Educatıon And Research Hospıtal, Karaman, Turkey

    Fatih Kaya

Authors
  1. Şerife Gülhan Konuk
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  2. Raşit Kılıç
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  3. Emine Türkoğlu Yılmaz
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  4. Fatih Kaya
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Contributions

ŞGK and ETY conceived of the presented idea. ŞGK developed the theory and performed the computations. ŞGK and RK verified the analytical methods. All authors discussed the results and contributed to the final manuscript.

Corresponding author

Correspondence to Şerife Gülhan Konuk.

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Conflict of interest

The authors declare that they have no conflict of interest.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the Tokat Gaziosmanpaşa University Faculty of Medicine clinical research ethics committee (Date: 02.09.2021/No: 21KAEK-196) and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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All participants agreed to the collection and anonymous publication of the data.

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Informed consent was obtained from all individual participants included in the study.

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Cite this article

Konuk, Ş.G., Kılıç, R., Yılmaz, E.T. et al. Evaluation of choroidal thickness and choroidal vascularity index in patients with Crimean-Congo hemorrhagic fever. Int Ophthalmol 43, 4163–4169 (2023). https://doi.org/10.1007/s10792-023-02817-9

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  • DOI: https://doi.org/10.1007/s10792-023-02817-9

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