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Development of interface haze after femtosecond laser-assisted in situ keratomileusis with accelerated corneal crosslinking: a case series

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Abstract

Background

Femtosecond laser-assisted in situ keratomileusis (FS-LASIK) with accelerated corneal crosslinking (FS-LASIK Xtra) is a recent procedure to achieve safer corneal ablation in myopic patients with borderline corneal thickness. Despite its well-accepted effectiveness, the development of remarkable interface haze is a potential concern but has rarely been reported and discussed.

Methods

We report for the first time a case series of 11 eyes of 7 patients who developed typical interface haze 1–3 months after FS-LASIK Xtra for the correction of myopia with astigmatism, with intensity grades ranging from 0.5 + to 3 + at the time of onset.

Results

The preclinical spherical diopters of the 7 patients ranged from − 2.25 D to − 9.25 D and cylindrical diopters ranged from − 0.25 D to − 2.50 D. The haze tended to be self-limiting, and topical anti-inflammatory therapy was given to moderate and severe cases, who responded well to treatment.

Conclusions

The development of clinically significant interface haze is a relatively rare complication after FS-LASIK Xtra but tends to have a higher incidence and intensity compared to conventional stromal surgery such as FS-LASIK. Timely treatment and close follow-up are essential to patients undertaking FS-LASIK Xtra.

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Funding

This work was supported by the Science & Technology Department of Sichuan Province (China) funding project (No. 2021YFS0221, No.2023YFS0179), 1.3.5 project for disciplines of excellence, West China Hospital, Sichuan University (No.2022HXFH032, ZYJC21058, 2021-023, 2022-014), and the Postdoctoral Research Funding of West China Hospital (No. 2020HXBH044).

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Author notes

  1. Hongbo Yin and Lixiang Wang have equally contributed to this work and also co-first authors.

Authors and Affiliations

  1. Department of Ophthalmology, West China Hospital, Sichuan University, No.37, Guoxue Alley, Chengdu, 610041, Sichuan, People’s Republic of China

    Hongbo Yin, Lixiang Wang, Rui Gong, Xiaolan Zhang & Ke Ma

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  1. Hongbo Yin
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  2. Lixiang Wang
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Contributions

All authors conducted clinical observation and the literature search. LW wrote the manuscript. HY the surgery and provided supervision. HY and KM revised the manuscript

Corresponding author

Correspondence to Ke Ma.

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The authors declare no conflict of interest.

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The studies involving human participants were reviewed and approved by the Ethics Committee of West China Hospital.

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The patients whose case reports are given in this manuscript provided their written informed consent for publication.

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Yin, H., Wang, L., Gong, R. et al. Development of interface haze after femtosecond laser-assisted in situ keratomileusis with accelerated corneal crosslinking: a case series. Int Ophthalmol 43, 4333–4342 (2023). https://doi.org/10.1007/s10792-023-02800-4

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