Skip to main content
SpringerLink
Log in

Incomplete retinal vascularization with retinopathy of prematurity-like ridges in healthy full-term newborns

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To describe the characteristics and clinical course of retinopathy of prematurity (ROP)-like ridges in healthy full-term newborns.

Methods

A retrospective medical record review was performed on newborns who underwent fundus photography within 72 h of birth between January 1st and December 31st, 2019 at Women & Children's Health Care Hospital of Huantai, China. The RetCam 3 wide-field digital imaging system was used for fundus photography. ROP-like ridges were discovered and described.

Results

Total of 5507 full-term infants underwent fundus photography. ROP-like ridges were discovered in 90 eyes from 57 infants (1.0%). Stage 1 ROP-like was seen in 63 of the eyes (70%), Stage 2 ROP-like in 26 of the eyes (28.9%), and Stage 3 ROP-like in 1 eye (1.1%). These ROP-like ridges were found in Zone II (41.1%) and Zone III (58.9%), but not in Zone I. Eight (8.9%) of the eyes had pre-plus-like diseases. No eyes had plus disease. All ROP-like ridges and pre-plus-like diseases were spontaneously regressed with a mean duration of 39.0 ± 8.2 days. Male sex (P = 0.003) was positively associated with ROP-like changes.

Conclusion

Healthy full-term newborns may have incomplete retinal vascularization and ROP-like ridges at birth. These ROP-like ridges showed signs of spontaneous regression.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Vinekar A, Govindaraj I, Jayadev C et al (2015) Universal ocular screening of 1021 term infants using wide-field digital imaging in a single public hospital in India - a pilot study. Acta Ophthalmol 93:e372–e376. https://doi.org/10.1111/aos.12685

    Article  PubMed  Google Scholar 

  2. Li LH, Li N, Zhao JY et al (2013) Findings of perinatal ocular examination performed on 3573, healthy full-term newborns. Br J Ophthalmol 97:588–591. https://doi.org/10.1136/bjophthalmol-2012-302539

    Article  PubMed  Google Scholar 

  3. Fei P, Liu Z, He L et al (2020) Early detection of ocular abnormalities in a Chinese multicentre neonatal eye screening programme-1-year result. Acta Ophthalmol 99(3):e415–e422. https://doi.org/10.1111/aos.14586

    Article  PubMed  PubMed Central  Google Scholar 

  4. Simkin SK, Misra SL, Battin M et al (2019) Prospective observational study of universal newborn eye screening in a hospital and community setting in New Zealand. BMJ Paediatr open 3:1–6. https://doi.org/10.1136/bmjpo-2018-000376

    Article  Google Scholar 

  5. Goyal P, Padhi TR, Das T et al (2018) Outcome of universal newborn eye screening with wide-field digital retinal image acquisition system: a pilot study. Eye 32:67–73. https://doi.org/10.1038/eye.2017.129

    Article  CAS  PubMed  Google Scholar 

  6. International Committee for the Classification of Retinopathy of P (2005) The international classification of retinopathy of prematurity revisited. Arch Ophthalmol 123:991–999. https://doi.org/10.1001/archopht.123.7.991

    Article  Google Scholar 

  7. Selvam S, Kumar T, Fruttiger M (2018) Retinal vasculature development in health and disease. Prog Retin Eye Res 63:1–19. https://doi.org/10.1016/j.preteyeres.2017.11.001

    Article  CAS  PubMed  Google Scholar 

  8. Liu D, Zheng J, Lu Y (2021) Fundus examination of 23,861 newborns by digital imaging in Ningbo. J Ophthalmol 2021:6620412. https://doi.org/10.1155/2021/6620412

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  9. Hartnett ME, Penn JS (2012) Mechanisms and management of retinopathy of prematurity. N Engl J Med 367:2515–2526. https://doi.org/10.1056/NEJMra1208129

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Kang EY-C, Lien R, Wang N-K et al (2018) Retinopathy of prematurity trends in Taiwan: a 10-year Nationwide population study. Invest Ophthalmol Vis Sci 59:3599–3607. https://doi.org/10.1167/iovs.18-24020

    Article  PubMed  Google Scholar 

  11. Ludwig CA, Chen TA, Hernandez-Boussard T et al (2017) The epidemiology of retinopathy of prematurity in the United States. Ophthalmic Surg Lasers Imaging Retin 48:553–562. https://doi.org/10.3928/23258160-20170630-06

    Article  Google Scholar 

  12. Li L, Gao Y, Chen W, Han M (2022) Screening for retinopathy of prematurity in North China. BMC Ophthalmol 22(1):1–8. https://doi.org/10.1186/s12886-022-02470-3

    Article  Google Scholar 

  13. Wasilewski D, Zago RJ, Bardal AMC et al (2002) Importance of the ophthalmological evaluation in newborns. J Pediatr (Rio J) 78:209–212

    Article  PubMed  Google Scholar 

  14. Ratra D, Akhundova L, Das MK (2017) Retinopathy of prematurity like retinopathy in full-term infants. Oman J Ophthalmol 10:167–172. https://doi.org/10.4103/ojo.OJO_141_2016

    Article  PubMed  PubMed Central  Google Scholar 

  15. Wang L, Li M, Zhu J et al (2021) Clinical features of spontaneous regression of retinopathy of prematurity in China: a 5-year retrospective case series. Front Med 8:731421. https://doi.org/10.3389/fmed.2021.731421

    Article  Google Scholar 

  16. Rao F-Q, Cai X-B, Cheng F-F et al (2017) Mutations in LRP5, FZD4, TSPAN12, NDP, ZNF408, or KIF11 genes account for 38.7% of chinese patients with familial exudative vitreoretinopathy. Invest Ophthalmol Vis Sci 58:2623–2629. https://doi.org/10.1167/iovs.16-21324

    Article  CAS  PubMed  Google Scholar 

Download references

Funding

National Natural Science Foundation of China (NSFC): Qiujing Huang 81900908. Science and Technology Commission of Shanghai Municipality, Shanghai Sailing Program: Qiujing Huang 19YF1432500. Science and Technology Commission of Shanghai Municipality, Shanghai Sailing Program: Jie Peng 20YF1429700. Science and Technology Bureau of Huantai County: Hua Zhu 2018kj070028. Shanghai Hospital Development Center: Peiquan Zhao SHDC2020CR5014-002. National Natural Science Foundation of China (NSFC): Peiquan Zhao 81770964.

Author information

Author notes

  1. Qiujing Huang and Cui Wang are co–first authors.

Authors and Affiliations

  1. Department of Ophthalmology, School of Medicine, Xinhua Hospital, Shanghai Jiao Tong University, Floor 11, No. 19 Building, 1665 Kongjiang Road, Shanghai, China, 200092

    Qiujing Huang, Jie Peng & Peiquan Zhao

  2. Department of Ophthalmology, Women’s & Children’s Health Care Hospital of Huantai, 5066 Yuyang Street, Huantai, Shandong, China, 256400

    Cui Wang, Yixuan Liu, Hua Zhu & Junli Yu

  3. Ophthalmology & Optometry Medical School, Shandong University of Traditional Chinese Medicine, Jinan, Shandong, China

    Han Yu

Authors
  1. Qiujing Huang
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Cui Wang
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Han Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Yixuan Liu
    View author publications

    You can also search for this author in PubMed Google Scholar

  5. Hua Zhu
    View author publications

    You can also search for this author in PubMed Google Scholar

  6. Jie Peng
    View author publications

    You can also search for this author in PubMed Google Scholar

  7. Junli Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  8. Peiquan Zhao
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

QH was responsible for the design of the study, the analysis and interpretation of data, drafting and revising the manuscript, and submission of the manuscript. CW was responsible for the design of the study, the acquisition, and analysis of the data, and drafting and revising the manuscript. HY was responsible for the design of the study, the acquisition of the data, and drafting and revising the manuscript. YL was responsible for the design of the study, the acquisition of the data, and drafting and revising the manuscript. HZ was responsible for the design of the study, the acquisition of the data, and drafting and revising the manuscript. JP was responsible for the design of the study, the analysis of the data, and revising the manuscript. JL was responsible for the design of the study, the acquisition of the data, drafting and revising the manuscript, and submission of the manuscript. PZ was responsible for the design of the study, the analysis and interpretation of the data, drafting and revising the manuscript, and submission of the manuscript.

Corresponding authors

Correspondence to Junli Yu or Peiquan Zhao.

Ethics declarations

Conflict of interest

The authors declare that they have no competing interests.

Ethics approval

This study was conducted with Institutional Review Board approval (by the Ethics Committee of Xin Hua Hospital Affiliated to Shanghai Jiao Tong University School of Medicine, Approval No. XHEC-D-2021–083) and adhered to the tenets of the Declaration of Helsinki.

Consent to participate

Before all examinations, a consent form was signed by each infant's parents or legal guardians.

Consent for publication

Not applicable.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Huang, Q., Wang, C., Yu, H. et al. Incomplete retinal vascularization with retinopathy of prematurity-like ridges in healthy full-term newborns. Int Ophthalmol 43, 3263–3268 (2023). https://doi.org/10.1007/s10792-023-02729-8

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-023-02729-8

Keywords

Search

Navigation