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Optic nerve sheath diameter and axial length in patients with optic disc drusen: a cross-sectional study

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Abstract

Aim

Measuring the optic nerve sheath diameter (ONSD) and the anteroposterior axial length of the eye in patients with optic disc drusen (ODD).

Methods

A total of 43 healthy volunteers and 41 patients with ODD were included in the study. The ONSD and axial length were measured in the posterior position using an ultrasound device (E-Z Scan AB5500 +) probe with a 10 MHz frequency. The ONSD was measured 3 mm behind the globe wall. Receiver operating characteristic (ROC) curve analysis was performed to determine patients with ODD using ONSD. Any p-value of < 0.05 was accepted to demonstrate significance.

Results

The ONSD was significantly higher (5.2 mm and 4.8 mm, p = 0.006, respectively), and the axial length was shorter (21.82 ± 2.15 mm and 23.27 ± 1.96 mm, p = 0.002, respectively) in the ODD group. The spherical equivalent was more commonly seen as hypermetropic in the ODD group (1.00 [− 0.85 to 1.75]). In the ROC analysis to determine the ONSD value in ODD diagnosis, the area under the curve was 0.6754 (95% confidence interval 0.559–0.788, p = 0.006). ONSD cutoff of 5.70 mm had a sensitivity of 0.366 and a specificity of 0.907 to diagnose ODD.

Conclusion

In this study, the ONSD was significantly higher in the ODD group. The axial length was shorter in the ODD group. This study is the first in the literature to evaluate the ONSD in patients with optic disc drusen. Further studies are needed in this regard.

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Acknowledgements

We are grateful to Beytepe Murat Erdi Eker State Hospital.

Funding

We had no financial supporting.

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Authors and Affiliations

  1. Department of Ophthalmology, Beytepe Şehit Murat Erdi Eker State Hospital, Ahlatlıbel Mh. 1746 Sk., 06800, Beytepe, Çankaya, Ankara, Turkey

    Kenan Dağdelen

  2. Department of Ophthalmology, Konya City Hospital, Konya, Turkey

    Emrah Dirican

Authors
  1. Kenan Dağdelen
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  2. Emrah Dirican
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Contributions

KD is the main author. Ophthalmologic evaluation, data collection and statistical evaluations were performed by KD. ED is a co-author and took part in the design and data analysis of the study. The authors reviewed and approved the final manuscript.

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Correspondence to Kenan Dağdelen.

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The authors declare no competing interests.

Conflict of interest

The authors declare that they have no competing interests.

Ethics approval and consent to participate

All procedures performed in studies involving human participants (including the use of human cell and/or tissue samples) were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards. The informed consent was obtained from all subjects or, if subjects are under 18, from a parent and/or legal guardian. The study was approved by the Clinical Research Ethics Board of the Republic of Turkey Ministry of Health Ankara City Hospital. Ethics Board. Clinical Research Ethics Board Identification Number: E1-21–1744.

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The data sets during and/or analyzed during the current study are available from the corresponding author on reasonable request.

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Dağdelen, K., Dirican, E. Optic nerve sheath diameter and axial length in patients with optic disc drusen: a cross-sectional study. Int Ophthalmol 43, 2109–2117 (2023). https://doi.org/10.1007/s10792-023-02654-w

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  • DOI: https://doi.org/10.1007/s10792-023-02654-w

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