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Evaluation of the corneal biomechanical properties and corneal thickness in patients with Graves’ orbitopathy

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Abstract

Purpose

To evaluate the corneal biomechanical properties and central corneal thickness in patients with Graves’ orbitopathy (GO).

Method

A total of 132 eyes of 66 patients with GO and 108 eyes of 54 healthy subjects were enrolled. Eyes with GO were classified as high score clinical activity score (CAS, ≥ 3) (Group 1, n = 64) and low CAS score (< 3) (Group 2, n = 68). Corneal biomechanical parameters [corneal hysteresis (CH), corneal resistance factor (CRF)], Goldmann-correlated intraocular pressure (IOPg), and corneal-compensated IOP (IOPcc) levels were measured with Ocular Response Analyzer (ORA, Reichert Ophthalmic Instruments, Buffalo, NY) and compared between the groups.

Results

The mean CH values were found as 9.6 ± 1 mmHg in Group 1, 10.2 ± 0.9 mmHg in Group 2, and 11.4 ± 1.7 mmHg in the Control Group (p < 0.001). In post hoc analysis the mean CH was significantly lower in Group 1 than Group 2 and Control Group (Group 1-Group 2, p < 0.001; Group 1-Control Group, p < 0.001). The mean CRF was found as 10.5 ± 2.1 in Group 1, 10.4 ± 2.2 in Group 2, and 10.43 ± 2.0 in the Control group. There was no statistically significant difference between the groups in CRF measurements (p = 0.959). The mean IOPcc values were found as 17.1 ± 3.6 mmHg in Group 1, 15.8 ± 4.0 mmHg in Group 2 and 15.2 ± 4.1 mmHg in the Control Group. The IOPcc and IOPg measurements between all groups were statistically significant (p = 0.009, p = 0.027, respectively).

Conclusions

Corneal biomechanical measurements were different in the GO patients with varying CAS scores compared to healthy individuals.

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Authors and Affiliations

  1. Department of Ophthalmology, Çerkezköy State Hospital, Cumhuriyet Mah. Melisa sok, Forest City 1 Sitesi, B1 blok, No: 15, Çerkezköy, Tekirdağ, Turkey

    Ferdane Ataş

  2. Department of Ophthalmology, Dokuz Eylul University, Izmir, Turkey

    Gül Arikan, Meltem Söylev Bajin, Mahmut Kaya & Aylin Yaman

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  1. Ferdane Ataş
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  2. Gül Arikan
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  3. Meltem Söylev Bajin
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  4. Mahmut Kaya
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  5. Aylin Yaman
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Contributions

Conception and design were contributed by FA, MSB, GA, MK, AY. Data collection, evaluation and analyses, preparation, review, and approval of the manuscript were contributed by all authors.

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Correspondence to Ferdane Ataş.

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Ataş, F., Arikan, G., Söylev Bajin, M. et al. Evaluation of the corneal biomechanical properties and corneal thickness in patients with Graves’ orbitopathy. Int Ophthalmol 43, 2257–2263 (2023). https://doi.org/10.1007/s10792-022-02621-x

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  • DOI: https://doi.org/10.1007/s10792-022-02621-x

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