Skip to main content

Advertisement

SpringerLink
Log in

Brain-derived neurotrophic factor levels and macular ganglion cell-inner plexiform layer thickness in macular telangiectasia type 2

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To determine brain-derived neurotrophic factor (BDNF) levels in the serum and aqueous humor (AH) and assess the relationship between BDNF levels and the thickness of the macular ganglion cell-inner plexiform layer (GCIPL) in macular telangiectasia type 2 (MacTel).

Methods

This study included 25 patients with MacTel (MacTel group) and 25 control subjects (control group). The levels of BDNF in the serum and AH were tested using an enzyme-binding immunosorbent assay. GCIPL thickness was measured by segmentation analysis using optical coherence tomography (OCT).

Results

There was no significant difference in the mean serum BDNF levels between the MacTel and control groups (p = 0.145). The average BDNF level in the AH was significantly lower than that in the control group (p = 0.026). OCT segmentation analyses revealed that the minimum GCIPL thickness was significantly lower in the MacTel group than in the control group (p = 0.039). In the correlation analysis of BDNF levels with GCIPL thickness, significant correlations existed between the BDNF level of the AH and minimum GCIPL thickness in the MacTel group.

Conclusion

The concentration of BDNF in the AH was decreased in the MacTel group, and this reduction was related to the minimum GCIPL thickness. The low BDNF levels detected in the MacTel group may have resulted in thinning of the GCIPL due to the loss of retinal ganglion cells.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1
Fig. 2

Similar content being viewed by others

Data and material availability

All relevant data are included in the manuscript.

References

  1. Jhingan M, Marsonia K, Shukla D, Rosenfeld PJ, Chhablani J (2017) Idopathic macular telangiectasis type 2 and co-existent diabetic retinopathy. Int J Retina Vitreous 3:50

    Article  PubMed  PubMed Central  Google Scholar 

  2. Christakis PG, Fine HF, Wiley HE (2019) The diagnosis and management of macular telangiectasia. Opthalmic Surg Lasers Imaging Retina 50(3):139–144

    Article  Google Scholar 

  3. Sauer L, Gensure RH, Hammer M, Bernstein PS (2018) Fluorescence lifetime imaging ophthalmoscopy : a novel way to assess macular telangiectasia type 2. Ophthalmol Retina 2(6):587–598

    Article  PubMed  Google Scholar 

  4. Stem MS, Gardner TW (2013) Neurodegeneration in the pathogenesis of diabetic retinopathy: molecular mechanisms and therapeutic implications. Curr Med Chem 20(26):3241–3250

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  5. Feng L, Chen H, Yi J et al (2016) Long-term protection of retinal ganglion cells and visual function by BDNF in mice with ocular hypertension. Investig Ophthalmol Vis Sci 57(8):3793–3802

    Article  CAS  Google Scholar 

  6. Dai M, Xia XB, Xiong SQ (2012) BDNF regulates GLAST and glutamine synthetase in mouse retinal Müller cells. J Cell Physiol 227:596–603

    Article  CAS  PubMed  Google Scholar 

  7. Ghaffariyeh A, Honarpisheh N, Shakiba Y et al (2009) Brain-derived neurotrophic factor in patients with normal-tension glaucoma. Optometry 80(11):635–638

    Article  PubMed  Google Scholar 

  8. Inanc M, Sekeroglu MA, Demirtas C et al (2018) Brain-derived neurotrophic factor in patients with age-related macular degeneration and its correlation with retinal layer thickness. Investig Ophthalmol Vis Sci 59(7):2833–2840

    Article  Google Scholar 

  9. Shpak AA, Gekht AB, Druzhkova TA, Kozlova KI, Gulyaeva NV (2018) Brain-derived neurotrophic factor in patients with primary open-angle glaucoma and age-related cataract. Curr Eye Res 43(2):224–231

    Article  CAS  PubMed  Google Scholar 

  10. Uzel AG, Uğurlu N, Toklu Y et al (2020) Relationship between stages of diabetic retinopathy and levels of brain-derived neurotrophic factor in aqueous humor and serum. Retina 40(1):121–125

    Article  Google Scholar 

  11. Pierro L, Gagliardi M, Iuliano L et al (2012) Retinal nerve fiber layer thickness reproducibility using seven different OCT instruments. Investiig Ophthalmol Vis Sci 53(9):5912–5920

    Article  Google Scholar 

  12. Chhablani J, Rao HB, Begum VU et al (2015) Retinal ganglion cells thinning in eyes with nonproliferative idiopathic macular telangiectasia type 2A. Invest Ophthalmol Vis Sci 56(2):1416–1422

    Article  PubMed  Google Scholar 

  13. Yoon CK, Yu HG (2018) Ganglion cell-inner plexiform layer and retinal nerve fiber later changes within the macula in retinitis pigmentosa: a spectral domain optical coherence tomography study. Acta Ophthalmol 96(2):180–188

    Article  Google Scholar 

  14. Tamhance M, Cabrera-Ghayouri S, Abelian G, Viswanath V (2019) Review of biomarkers in ocular matrices: challenges and opportunities. Pharm Res 36(3):40

    Article  Google Scholar 

  15. Benarroch EE (2015) Brain-derived neurotrophic factor: Regulation, effects, and potential clinical relevance. Neurology 84(16):1693–1704

    Article  PubMed  Google Scholar 

  16. Erickson KI, Prakash RS, Voss MW et al (2010) Brain-derived neurotrophic factors is associated with age-related decline in hippocampal volume. J Neurosci 30(15):5368–5375

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  17. Bathina S, Das UN (2015) Brain-derived neurotrophic factor and its clinical implications. Arch Med Sci 11(6):1164–1178

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  18. Azevedo KPM, de Oliveira VH, Medeiros GCBS et al (2020) The effects of exercise on BDNF levels in adolescents: a systematic review with meta-analysis. Int J Environ Res Public Health 17(17):6056

    Article  PubMed  PubMed Central  Google Scholar 

  19. Laske C, Banschbach S, Stransky E et al (2010) Exercise-induced normalization of decreased BDNF serum concentration in elderly women with remitted major depression. Int J Neuropsychopharmacol 13(5):595–602

    Article  CAS  PubMed  Google Scholar 

  20. Kaviarasan K, Jithu M, ArifMulla M et al (2015) Low blood and vitreal BDNF, LXA4 and altered Th1/Th2 cytokine balance are potential risk factors for diabetic retinopathy. Metab Clin Exp 64:958–966

    Article  CAS  PubMed  Google Scholar 

  21. Sung MS, Yoon JH, Park SW (2014) Diagnostic validity of macular ganglion cell-inner plexiform layer thickness deviation map algorithm using cirrus HD-OCT in preperimetric and early glaucoma. J Glaucoma 23:144–151

    Article  Google Scholar 

  22. Park KA, Park DY, Oh SY (2011) Analysis of spectral-domain optical coherence tomography measurements in amblyopia: a pilot study. Br J Ophthalmol 95:1700–1706

    Article  PubMed  Google Scholar 

  23. Powner MB, Gillies MC, Zhu M, Vevis K, Hunyor AP, Fruttiger M (2013) Loss of M¨uller’s cells and photoreceptors in macular telangiectasia type 2. Ophthalmology 120:2344–2352

    Article  PubMed  Google Scholar 

  24. Noma H, Funatsu H, Mimura T, Harino S, Hori S (2010) Aqueous humor levels of vasoactive molecules correlate with vitreous levels and macular edema in central retinal vein occlusion. Eur J Ophthalmol 20:402–409

    Article  PubMed  Google Scholar 

Download references

Funding

This study was supported by a research fund from Chosun University Hospital, 2021.

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Chosun University, 365 Pilmun-daero, Dong-gu, Gwangju, 61453, Republic of Korea

    Jun Young Yu, Da Eun Jeong & Seong Taeck Kim

  2. Department of Pediatrics, Chosun University, College of Medicine, Gwangju, Republic of Korea

    Jung Yeon Joo

Authors
  1. Jun Young Yu
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Da Eun Jeong
    View author publications

    You can also search for this author in PubMed Google Scholar

  3. Jung Yeon Joo
    View author publications

    You can also search for this author in PubMed Google Scholar

  4. Seong Taeck Kim
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

ST Kim designed the study, JY Yu and DE Jeong participated in sample collection, and JY Joo and ST Kim analyzed the obtained data. All authors have read and approved the final manuscript.

Corresponding author

Correspondence to Seong Taeck Kim.

Ethics declarations

Competing interests

Authors have no potential conflict of interest to declare.

Ethics approval

The Institutional Review Board Ethics Committee of the Chosun University Hospital approved this study.

Consent to participate

Written informed consent was obtained from all study participants.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Supplementary Information

Below is the link to the electronic supplementary material.

Supplementary file1 (XLSX 14 kb)

Rights and permissions

Springer Nature or its licensor (e.g. a society or other partner) holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Yu, J.Y., Jeong, D.E., Joo, J.Y. et al. Brain-derived neurotrophic factor levels and macular ganglion cell-inner plexiform layer thickness in macular telangiectasia type 2. Int Ophthalmol 43, 1927–1933 (2023). https://doi.org/10.1007/s10792-022-02592-z

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-022-02592-z

Keywords

Search

Navigation