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Clinical observations of corneal topographic and tomographic changes in congenital ptosis eyes: a study in China

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Abstract

Purpose

To investigate the impact of drooping eyelid on corneal topographic and tomographic alterations in congenital ptosis eyes.

Methods

Seventeen Chinese patients with unilateral congenital ptosis were included in this observational study. Ptosis eyes were included in the ptosis group, while normal contralateral eyes were included in the control group. The marginal reflex distance (MRD) was used to evaluate the severity of ptosis. Topographic and tomographic parameters measured by Pentacam, including keratometric, pachymetric, volumetric parameters as well as topometric indexes and D indexes, were recorded and compared between the ptosis group and the control group. Furthermore, correlation analyses were made between MRD and all measured corneal parameters.

Results

The value of anterior K1, Km and posterior K2, Km was significantly decreased in the ptosis eyes (p < 0.05). Corneal thickness at the pupil center point and thinnest point was significantly thicker in ptosis group compared with the ones in control group (p < 0.05). Higher ISV, IVA, KI, IHD values were observed in ptosis eyes (p < 0.05). The intergroup difference in MRD showed significant correlation with the difference in ISV (p < 0.05).

Conclusion

The whole corneal contour is remodeled to be “flatter” in ptosis eyes. The upper eyelid position was closely associated with the corneal irregularity in ptosis eyes. The reasons for the discrepancy in corneal topography and tomography between ptotic and normal eyes were complicated.

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Funding

The authors declare that no funds, grants or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Ophthalmology, First Affiliated Hospital, School of Medicine, Zhejiang University, Qingchun Road No. 79, Hangzhou, 310003, People’s Republic of China

    Jianqin Shen, Huiyan Li, Yanhong Chen, Lan Liu & Hongguang Cui

Authors
  1. Jianqin Shen
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  2. Huiyan Li
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  3. Yanhong Chen
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  4. Lan Liu
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  5. Hongguang Cui
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Contributions

JS drafted the manuscript and performed the statistical analysis. JS, HL and YC collected the data. LL was responsible for screening references. HC conceived of the study and revised the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Hongguang Cui.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Consent to participate

Written informed consent was obtained from legal parent/guardian for participants less than 18 years old and from participants directly for those 18 years or older.

Ethical approval

The study was approved by the Institutional Review Board of First Affiliated Hospital, College of Medicine, Zhejiang University. The tenets of the Declaration of Helsinki were followed for all study procedures.

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Shen, J., Li, H., Chen, Y. et al. Clinical observations of corneal topographic and tomographic changes in congenital ptosis eyes: a study in China. Int Ophthalmol 43, 1581–1590 (2023). https://doi.org/10.1007/s10792-022-02557-2

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  • DOI: https://doi.org/10.1007/s10792-022-02557-2

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