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Assessment the neurodegenaration process of post-geniculate optic pathway in thalamic tumors using optical coherence tomography: Post-geniculate optic pathway in thalamic tumors

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Abstract

Purpose

To investigate the effect of thalamic tumors related to post-geniculate optic pathway and those of microsurgical removal on neurodegeneration process of visual pathway using OCT.

Methods

This cross-sectional study included 30 eyes of 15 patients with thalamic tumors and data compiled from 45 eyes of 45 healthy participants. The analysis of variables was divided into ipsilateral and contralateral eye depends on the laterality of brain tumors. The data gained at baseline, postoperative 3rd and postoperative 6th month period was analyzed in One-Way Repeated Measures ANOVA.

Results

The mean superior quadrant retinal nerve fiber layer (RNFL) thickness of ipsilateral eye was significantly thicker (p = 0.02), while inferior hemifield ganglion cell-inner plexiform layer (GC-IPL) thickness of contralateral eye was significantly higher compared to control groups (p = 0.02). Significant negative correlations were found between the mean preop. mean deviation (MD) and tumor volume and time interval between initial diagnosis and surgery (r = − 0.730, p = 0.002 and r = − 0.680, p = 0.005, respectively) in the ipsilateral eye. In repeated measure analysis, there was no unfavourable effect of thalamic microsurgery on peripapillary average RNFL thickness on both ipsilateral and contralateral eyes (Ipsilateral eye; f (1.5,21.7) 0.76 p = 0.51 and contralateral eye; f (1.4,20.4) 0.42 p = 0.59).

Conclusion

This study suggests that thalamic tumors affecting post-geniculate optic pathway may lead to significant increase in RNFL and GC-IPL thicknesses and changes in VF parameters. Timely intervention in thalamic tumors may prevent irreversible loss of retinal axons secondary to neurodegeneration process.

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Data availability

Data are available upon reasoanble request from the authors.

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Acknowledgements

The authors have no any person or institution to state their acknowledgments.

Funding

This research did not receive any specific grant from funding agencies in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Ophthalmology, FEBO, Universtiy of Health Science, Umraniye Education and Training Hospital, Yeditepe University School of Medicine, 34764, Istanbul, Turkey

    Yasin Özcan

  2. Department of Ophthalmology, Yeditepe University School of Medicine, Istanbul, Turkey

    Alp Kayıran

  3. Department of Radiology, Yeditepe University School of Medicine, Istanbul, Turkey

    Gazanfer Ekinci

  4. Department of Neurosurgery, Yeditepe University School of Medicine, Istanbul, Turkey

    Uğur Türe

Authors
  1. Yasin Özcan
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  2. Alp Kayıran
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  3. Gazanfer Ekinci
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  4. Uğur Türe
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Contributions

Ozcan Y designed the study, collected the data and wrote the main manuscritp text, Kayiran A helped to statistical analyze data and correction paper, Ekinci G corrected paper and analyzed data regarding radiologic cranial images, Ture U carried out all cranial surgical procedures, correction of paper and evaluation the accuracy of data gained those patients.

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Correspondence to Yasin Özcan.

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Özcan, Y., Kayıran, A., Ekinci, G. et al. Assessment the neurodegenaration process of post-geniculate optic pathway in thalamic tumors using optical coherence tomography: Post-geniculate optic pathway in thalamic tumors. Int Ophthalmol 43, 1487–1499 (2023). https://doi.org/10.1007/s10792-022-02545-6

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  • DOI: https://doi.org/10.1007/s10792-022-02545-6

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