Skip to main content

Advertisement

SpringerLink
Log in

Evaluation of 25-Hydroxyvitamin D levels in patients with dermatochalasis

  • Original Paper
  • Published:
International Ophthalmology Aims and scope Submit manuscript

Abstract

Purpose

To compare serum 25-hydroxyvitamin D (25(OH)D) levels of patients with dermatochalasis who underwent upper lid blepharoplasty and healthy controls.

Methods

This retrospective comparative study included dermatochalasis patients who underwent upper lid blepharoplasty and age-and sex-matched controls from January 2019 to January 2021. The data, including comprehensive ophthalmological examination, internal medicine outpatient examination, and laboratory results of the dermatochalasis patients and healthy controls, were collected from the electronic patient records. Serum 25(OH)D, creatinine, calcium (Ca), phosphate (P), triglyceride (TG), low-density lipoprotein (LDL), and high-density lipoprotein (HDL) levels were evaluated and compared between the dermatochalasis patients and healthy controls.

Result

Of our participants, consisting of 46 patients with dermatochalasis and 52 healthy controls, 54 (55.10%) were female and 44 (44.90%) were male. A statistically significant difference was observed in vitamin D levels between the healthy and dermatochalasis groups (p ≤ 0.001). The percentage of individuals with vitamin D deficiency (< 20 ng/mL) was significantly higher in the dermatochalasis group (p = 0.001). In addition, the percentage of individuals with severe vitamin D deficiency (< 10 ng/mL) was again significantly higher in the dermatochalasis group (p = 0.001). The risk of dermatochalasis incidence was found to increase in cases of low vitamin D (OR = 1.210; p = 0.017).

Conclusion

Low serum 25(OH)D levels may play a role in the etiopathogenesis of dermatochalasis. Future research should include longitudinal studies and prospective clinical studies to investigate the mechanism responsible for the low vitamin D observed in dermatochalasis patients.

This is a preview of subscription content, log in via an institution to check access.

Access this article

Log in via an institution

Price excludes VAT (USA)
Tax calculation will be finalised during checkout.

Instant access to the full article PDF.

Institutional subscriptions

Fig. 1

Similar content being viewed by others

References

  1. Karnaz A, Katircioglu YA, Ozdemir ES et al (2018) The Histopathological findings of patients who underwent blepharoplasty due to dermatochalasis. Semin Ophthalmol 33:407–411

    Article  PubMed  Google Scholar 

  2. Nagi KS, Carlson JA, Wladis EJ (2011) Histologic assessment of dermatochalasis: elastolysis and lymphocytosis are fundamental and interrelated findings. Ophthalmology 118:1205–1210

    Article  PubMed  Google Scholar 

  3. Brown MS, Siegel IM, Lisman RD (1999) Prospective analysis of changes in corneal topography after upper eyelid surgery. Ophthal Plast and Reconstr Surg 15:378–383

    Article  CAS  Google Scholar 

  4. Baylis HI, Golberg RA, Kerivan K, Jacobs J (1997) Analysis and treatment of the aging face. Dermatol Clin 15:635–647

    Article  CAS  PubMed  Google Scholar 

  5. Reichrath J, Saternus R, Vogt T (2017) Endocrine actions of vitamin D in skin: Relevance for photocarcinogenesis of non-melanoma skin cancer, and beyond. Mol Cell Endocrinol 453:96–102

    Article  CAS  PubMed  Google Scholar 

  6. Bikle DD (2020) Vitamin D: Newer Concepts of Its Metabolism and Function at the Basic and Clinical Level. J Endocr Soc.;4:bvz038.

  7. Wadhwa B, Relhan V, Goel K, Kochhar AM, Garg VK (2015) Vitamin D and skin diseases: a review. Indian J Dermatol Venereol Leprol 81:344–355

    Article  PubMed  Google Scholar 

  8. Toniato E, Spinas E, Saggini A et al (2015) Immunomodulatory effects of vitamin D on skin inflammation. J Biol Regul Homeost Agents 29:563–567

    CAS  PubMed  Google Scholar 

  9. Shab-Bidar S, Neyestani TR, Djazayery A, Eshraghian MR, Houshiarrad A et al (2011) Regular consumption of vitamin D-fortified yogurt drink (Doogh) improved endothelial biomarkers in subjects with type 2 diabetes: a randomized double-blind clinical trial. BMC Med 9:125

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  10. Nagpal S, Na S, Rathnachalam R (2005) Noncalcemic actions of vitamin D receptor ligands. Endocr Rev 26:662–687

    Article  CAS  PubMed  Google Scholar 

  11. Hollis BW (2008) Assessment of vitamin D status and definition of a normal circulating range of 25-hydroxyvitamin D. Curr Opin Endocrinol Diabetes Obes 15:489–494

    Article  CAS  PubMed  Google Scholar 

  12. Slominski AT, Zmijewski MA, Plonka PM, Szaflarski JP, Paus R (2018) How UV Light Touches the Brain and Endocrine System Through Skin, and Why. Endocrinology 159:1992–2007

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  13. Young AR (2006) Acute effects of UVR on human eyes and skin. Prog Biophys Mol Biol 92:80–85

    Article  CAS  PubMed  Google Scholar 

  14. Akkaya S, Ulusoy DM (2020) Serum Vitamin D Levels in Patients with Keratoconus. Ocul Immunol Inflamm 28(3):348–353

    Article  CAS  PubMed  Google Scholar 

  15. Holick MF, Binkley NC, Bischoff-Ferrari HA et al (2011) Evaluation, treatment, and prevention of vitamin D deficiency: an endocrine society clinical practice guideline. J Clin Endocrinol Metab 96:1911–1930

    Article  CAS  PubMed  Google Scholar 

  16. Kim EC, Han K, Jee D (2014) Inverse relationship between high blood 25-hydroxyvitamin D and late stage of age-related macular degeneration in a representative Korean population. Invest Ophthalmol Vis Sci 55:4823–4831

    Article  CAS  PubMed  Google Scholar 

  17. Choi JA, Han K, Park YM, La TY (2014) Low serum 25-hydroxyvitamin D is associated with myopia in Korean adolescents. Invest Ophthalmol Vis Sci 55:2041–2047

    Article  CAS  PubMed  Google Scholar 

  18. Jee D, Kim EC (2015) Association between serum 25-hydroxyvitamin D levels and age-related cataracts. J Cataract Refract Surg 41:1705–1715

    Article  PubMed  Google Scholar 

  19. Jee Donghyun, Kang Seungbum, Yuan Changzheng, Cho Eunyoung, Arroyo Jorge G (2016) Serum 25-Hydroxyvitamin D Levels and Dry Eye Syndrome: Differential Effects of Vitamin D on Ocular Diseases. PLOS ONE 11(2):e0149294. https://doi.org/10.1371/journal.pone.0149294

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  20. Vitamin D (2015) Implications for ocular disease and therapeutic potential. Reins RY. McDermott AM. Exp Eye Res. 134:101–110

    Article  Google Scholar 

  21. Alia E, Kerr PE (2021) Vitamin D: Skin, sunshine, and beyond. Clinics in Dermatology Clin Dermatol 39:840–846

    Article  PubMed  Google Scholar 

  22. Colotta F, Jansson B, Bonelli F (2017) Modulation of inflammatory and immune responses by vitamin D. J Autoimmun 85:78–97

    Article  CAS  PubMed  Google Scholar 

  23. Barragan M, Good M, Kolls JK (2015) Regulation of dendritic cell function by vitamin D. Nutrients 7:8127–8151

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  24. Stoffels K, Overbergh L, Bouillon R, Mathieu C (2007) Immune regulation of 1alpha-hydroxylase in murine peritoneal macrophages: Unravelling the IFNgamma pathway. J Steroid Biochem Mol Biol 103:567–571

    Article  CAS  PubMed  Google Scholar 

  25. Agliano M, Lorenzoni P, Volpi N et al (2008) Lymphatic vessels in human eyelids: an immunohistological study in dermatochalasis and chalazion. Lymphology 41:29–39

    CAS  PubMed  Google Scholar 

  26. Dozsa A, Karolyi ZS, Degrell P (2005) Bilateral blepharochalasis. J Eur Acad Dermatol Venereol 19:725–728

    Article  CAS  PubMed  Google Scholar 

  27. Daroczy J (1995) Pathology of lymphedema. Clin Dermatol 13:433–444

    Article  CAS  PubMed  Google Scholar 

  28. Sasaki H, Kawakami Y, Ono M, Jonasson F, Shui YB, Cheng HM, Robman L, McCarty C, Chew SJ, Sasaki K (2003) Localization of cortical cataract in subjects of diverse races and latitude. Invest Ophthalmol Vis Sci 44:4210–4214

    Article  PubMed  Google Scholar 

  29. Sherwin JC, Hewitt AW, Kearns LS, Griffiths LR, Mackey DA, Coroneo MT (2013) The association between pterygium and conjunctival ultraviolet autofluorescence: the Norfolk Island Eye Study. Acta Ophthalmol 91:363–370

    Article  PubMed  Google Scholar 

  30. Millen AE, Voland R, Sondel SA, Parekh N, Horst RL, Wallace R, B, et al (2011) Vitamin D status and early age-related macular degeneration in postmenopausal women. Arch Ophthalmol. 129:481–489

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  31. Gray RH, Johnson GJ, Freedman A (1992) Climatic droplet keratopathy. Surv Ophthalmol 36:241–253

    Article  CAS  PubMed  Google Scholar 

  32. Bilak Ş, Yılmaz S, Bilgin B (2021) Comparison of vitamin D levels between patients with pterygium and healthy subjects. Int Ophthalmol 41:3057–3064

    Article  PubMed  Google Scholar 

  33. Öktem Ç, Aslan F (2021) Vitamin D Levels in Young Adult Cataract Patients: A Case-Control Study. Ophthalmic Res 64:116–120

    Article  PubMed  Google Scholar 

  34. Parekh N, Chappell RJ, Millen AE, Albert DM, Mares JA (2007) Association between vitamin D and age-related macular degeneration in the Third National Health and Nutrition Examination Survey, 1988 through 1994. Arch Ophthalmol 125:661–669

    Article  CAS  PubMed  Google Scholar 

  35. Kan E, Kan EK, Yücel ÖE (2020) The Possible Link Between Vitamin D Levels and Exudative Age-related Macular Degeneration. Oman Med J 35:e83

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  36. Jee D, Kim EC, Cho E, Arroyo JG (2016) Positive Association between Blood 25-Hydroxyvitamin D Levels and Pterygium after Control for Sunlight Exposure. PLoS ONE 11:e0157501

    Article  PubMed  PubMed Central  Google Scholar 

  37. Rao P, Millen AE, Meyers KJ, Liu Z, Voland R, Sondel S et al (2015) The Relationship Between Serum 25-Hydroxyvitamin D Levels and Nuclear Cataract in the Carotenoid Age-Related Eye Study (CAREDS), an Ancillary Study of the Women’s Health Initiative. Invest Ophthalmol Vis Sci 56:4221–4230

    Article  CAS  PubMed  PubMed Central  Google Scholar 

  38. Cougnard-Grégoire A, Merle BM, Korobelnik JF, Rougier MB, Delyfer MN, Féart C, Le Goff M, Dartigues JF, Barberger-Gateau P, Delcourt C (2015) Vitamin D Deficiency in Community-Dwelling Elderly Is Not Associated with Age-Related Macular Degeneration. J Nutr 145:1865–1872

    Article  PubMed  Google Scholar 

  39. Heaney RP, Davies KM, Chen TC et al (2003) Human serum 25- hydroxycholecalciferol response to extended oral dosing with cholecalciferol. Am J Clin Nutr 77:204–210

    Article  CAS  PubMed  Google Scholar 

Download references

Acknowledgements

Res. Asst. Emre Gökay Özgür (statistician) for review of statistics.

Funding

No funding was received for this research.

Author information

Authors and Affiliations

  1. Kocaeli Derince Education and Research Hospital Ophthalmology Department , Lojman Sk İbni Sina, 41900, Derince, , Kocaeli, Turkey

    Sevim Ayça Seyyar & Ecem Onder Tokuc

Authors
  1. Sevim Ayça Seyyar
    View author publications

    You can also search for this author in PubMed Google Scholar

  2. Ecem Onder Tokuc
    View author publications

    You can also search for this author in PubMed Google Scholar

Contributions

Study design, data acquisition, research, manuscript were performed by Sevim Ayça Seyyar, Manuscript editing, research, data acquisition were performed by Ecem Önder Tokuç, All authors read and approved the final manuscript.

Corresponding author

Correspondence to Sevim Ayça Seyyar.

Ethics declarations

Competing interests

The authors declare no competing interests.

Conflict of interest

None of the authors have any financial/conflicting interests to disclose.

Ethics committee number

Derince Training and Research Hospital ethics committee 2022–22.

Additional information

Publisher's Note

Springer Nature remains neutral with regard to jurisdictional claims in published maps and institutional affiliations.

Rights and permissions

Springer Nature or its licensor holds exclusive rights to this article under a publishing agreement with the author(s) or other rightsholder(s); author self-archiving of the accepted manuscript version of this article is solely governed by the terms of such publishing agreement and applicable law.

Reprints and permissions

About this article

Check for updates. Verify currency and authenticity via CrossMark

Cite this article

Seyyar, S.A., Tokuc, E.O. Evaluation of 25-Hydroxyvitamin D levels in patients with dermatochalasis. Int Ophthalmol 43, 749–756 (2023). https://doi.org/10.1007/s10792-022-02474-4

Download citation

  • Received:

  • Accepted:

  • Published:

  • Issue Date:

  • DOI: https://doi.org/10.1007/s10792-022-02474-4

Keywords

Search

Navigation