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Clinicopathological profile, management and clinical outcomes in recurrent cases of ocular surface squamous neoplasia at a tertiary care centre

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Abstract

Purpose

This study was taken up to look into the various causes of recurrence, clinicopathological profile and final outcomes in recurrent cases of ocular surface squamous neoplasia (OSSN).

Methodology

A prospective cohort study was conducted and total 18 patients were recruited. All patients were subjected to detailed history, comprehensive eye examination and imaging studies. A treatment plan was formulated based on the size and extent of the lesion. The primary outcome measure was complete response to treatment with no evidence of recurrence after12 months and secondary outcome measure was complication associated with each treatment modality.

Results

The common cause of recurrence in our study was misdiagnosis of the lesion as in 15 cases it was diagnosed as pterygium and in 03 cases it was actinic keratosis. Excision Biopsy with adjunctive cryotherapy was the preferred treatment modality followed by topical interferon-alpha 2b drop-in our study. We could achieve good outcomes in terms of complete response to the treatment in 16 cases. The complication associated with this treatment was minimal in our study as few patients complained redness and irritation which subsided after application of topical lubricants. There was no sign of recurrence even at 12 months of follow-up in all 18 cases.

Conclusion

The current study provided clinicopathological characteristics and treatment outcomes in recurrent cases of OSSN. In our study, adopting appropriate treatment strategy, regular follow-up to assess the response to treatment and change over to new treatment plan in cases with inadequate response helped in achieving good outcomes in recurrent cases of OSSN.

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Funding

No funding was received for this research.

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Authors and Affiliations

  1. Army Hospital Research and Referral, Delhi, 110010, India

    Sonali Vinay Kumar, Sanjay Kumar Mishra & Alok Sati

  2. Venkateshwara Institute of Medical Sciences, Gajraula, Uttar Pradesh, India

    Vinay Kumar

Authors
  1. Sonali Vinay Kumar
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  2. Vinay Kumar
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  3. Sanjay Kumar Mishra
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  4. Alok Sati
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Contributions

Conceptualization SVK, VK; methodology: SVK, AS; formal analysis SVK, SKM; writing-original draft preparation; SVK, VK; writing-review and editing: SVK, SKM, AS; supervision; SKM.

Corresponding author

Correspondence to Sonali Vinay Kumar.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethical approval

All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional reserch committee (Army Hospital Reserch & Referral) and with the 1964 Helsiniki Declaration and its amendments or comparable ethical standards. This manuscript did not involve any kind of animal research. All the authors consent to the publication of this manuscript in International Ophthalmology.

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Kumar, S.V., Kumar, V., Mishra, S.K. et al. Clinicopathological profile, management and clinical outcomes in recurrent cases of ocular surface squamous neoplasia at a tertiary care centre. Int Ophthalmol 43, 371–380 (2023). https://doi.org/10.1007/s10792-022-02432-0

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  • DOI: https://doi.org/10.1007/s10792-022-02432-0

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