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Clinicopathological characteristics of ocular surface squamous neoplasia: a 10-year review form a referral tertiary centre in Nigeria

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Abstract

Background

Ocular surface squamous neoplasia (OSSN) is a heterogeneous group of proliferative squamous lesions on the ocular surface with varying biologic behaviours. This study aims to report the clinical profile and pathological characteristics of cases of OSSN seen at a tertiary referral centre in North West Nigeria.

Methods

A retrospective review of all cases of OSSN diagnosed over a 10-year period was done.

Results

OSSN accounted for 68 out of 91 ocular surface lesions affecting twice as many males as females and a peak incidence in the 30–39 years age group. They frequently presented as higher-grade and higher-stage lesions with invasive squamous cell carcinoma being the most frequently diagnosed OSSN. They also frequently showed an association with HIV infection and a relatively long duration of symptoms before presentation.

Conclusion

OSSN occurs in a relatively young age group in our environment. Certain clinical and epidemiological features appear to predict the occurrence of higher-grade lesions, and this may help in the clinical prediction of likely pathologic grade and/or biologic behaviour of these lesions.

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Funding

The authors declare that no funds, grants, or other support were received during the preparation of this manuscript.

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Authors and Affiliations

  1. Department of Histopathology, College of Medical Sciences, Abubakar Tafawa Balewa University, Bauchi, 7204212, Nigeria

    Dauda Eneyamire Suleiman

  2. Departent of Pathology, College of Medical Sciences, Ahmadu Bello University, Zaria, Nigeria

    Almustapha Aliyu Liman, Garba Dahiru Waziri & Saad Aliyu Ahmed

  3. Department of Anatomic Pathology and Forensic Medicine, Faculty of Clinical Sciences, Kaduna State University, Kaduna, Nigeria

    Yawale Iliyasu

Authors
  1. Dauda Eneyamire Suleiman
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  2. Almustapha Aliyu Liman
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  3. Garba Dahiru Waziri
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  4. Yawale Iliyasu
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  5. Saad Aliyu Ahmed
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Contributions

All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by DES, AAL and GDW. The first draft of the manuscript was written by DES, and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Dauda Eneyamire Suleiman.

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Conflict of interest

The authors have no relevant financial or non-financial interests to disclose.

Ethical approval

Ethical clearance was received from the institutional Hospital Research and Ethics Committee (HREC). [HREC Number: ABUTH/HREC/M32/2014; Date of approval: 30th December, 2014].

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Suleiman, D.E., Liman, A.A., Waziri, G.D. et al. Clinicopathological characteristics of ocular surface squamous neoplasia: a 10-year review form a referral tertiary centre in Nigeria. Int Ophthalmol 42, 3905–3911 (2022). https://doi.org/10.1007/s10792-022-02411-5

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  • DOI: https://doi.org/10.1007/s10792-022-02411-5

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