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Long-term evaluation of posterior corneal surface parameters after accelerated corneal cross-linking with a comparison with uncross-linked keratoconic eyes

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Abstract

Purpose

To evaluate the 36 months changes in posterior corneal surface parameters in keratoconic eyes after accelerated corneal cross-linking and to compare the data with uncross-linked progressive and non-progressive keratoconic eyes.

Methods

Thirty five cross-linked, 30 uncross-linked progressive, and 30 uncross-linked non-progressive keratoconic eyes were included. Maximum keratometry (Kmax), thinnest pachymetry, minimum radius of curvature back (Rminback), asphericity back, posterior elevation and corneal densitometry, back corneal higher order aberrations (HOAs), back surface deviation (Db), final D, posterior radius of curvature (PRC) and ‘B’ unit values were recorded at baseline and at the 12, 24, 36 months follow-up. Data were analyzed with repeated measures ANOVA and paired t-tests.

Results

Kmax and thinnest pachymetry were significantly changed in the cross-linked and progressive uncross-linked groups. Rminback, asphericity back, and HOAs did not change in either group. Total posterior corneal densitometry improved; posterior elevation, Db and B unit worsened in the cross-linked group and did not change in the uncross-linked groups. PRC and final D worsened in the cross-linked and progressive uncross-linked groups, and did not change in the non-progressive group.

Conclusion

Despite a decreased Kmax, the posterior corneal surface parameters, posterior elevation values were determined to have significantly worsened in the cross-linked group and this increase was higher than in progressive uncross-linked eyes.

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Data availability

Due to the nature of this research, participants of this study did not agree for their data to be shared publicly, so supporting data is not available.

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Acknowledgements

The study was reviewed by a native English speaker, Dr. Caroline J. Walker, Ph. D.

Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Ulucanlar Eye Training and Research Hospital, Ulucanlar Street, Number: 59, 06240, Ankara, Turkey

    Pinar Kosekahya, Mine Turkay, Esra Bahadir Camgoz & Mustafa Ilker Toker

  2. Special İdeal Eye Hospital, Kayseri, Turkey

    Mustafa Koc

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  1. Pinar Kosekahya
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  2. Mine Turkay
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  4. Mustafa Koc
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Correspondence to Pinar Kosekahya.

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Kosekahya, P., Turkay, M., Camgoz, E.B. et al. Long-term evaluation of posterior corneal surface parameters after accelerated corneal cross-linking with a comparison with uncross-linked keratoconic eyes. Int Ophthalmol 42, 3725–3738 (2022). https://doi.org/10.1007/s10792-022-02370-x

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  • DOI: https://doi.org/10.1007/s10792-022-02370-x

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