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Repeatability of i.Profiler for measuring wavefront aberrations in healthy eyes

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Abstract

Purpose

To evaluate the repeatability of wavefront aberration measurements and the correlation between corneal aberration and pupil size in normal eyes using a wavefront-based autorefractor (i.ProfilerPlus; Carl Zeiss Vision, Germany).

Methods

A prospective cross-sectional study. Wavefront aberrations, including spherical aberration (SA) (Z40), coma (Z3−1, Z31), trefoil (Z3−3, Z33) and total higher-order aberrations (tHOA), were measured at different pupil diameters. The repeatability was evaluated using one-way ANOVA method, and statistical indicators including within-subject standard deviation (Sw), test–retest repeatability (TRT), and intra-class correlation coefficient (ICC). The correlations between corneal aberrations and pupil sizes were evaluated by Pearson correlation analysis.

Results

A total of 96 healthy young volunteers were enrolled. Corneal and ocular higher-order aberrations (HOA) measured by i.Profiler showed Sw < 0.01 μm, TRT < 0.10 μm, ICC > 0.90. There was a linear positive correlation between the corneal HOA and pupil size. The correlation coefficient between SA and tHOA was the largest (r = 0.996, P < 0.001).

Conclusions

The measurements of wavefront aberrations by i.Profiler are highly repeatable. Corneal HOA was significantly dependent on pupil size. SA was the most influential aberration for visual quality in this study.

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Availability of data and material

The data that support the findings of this study are available from the corresponding author upon reasonable request and after permission of Affiliated Hospital of North Sichuan Medical College.

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Acknowledgements

This work was supported by the Key Project of Sichuan Health and Family Planning Commission (18ZD022) and the Key Project of Nanchong City and University Cooperation (18SXHZ0492).

Funding

This work was supported by the Key Project of Sichuan Health and Family Planning Commission (18ZD022) and the Key Project of Nanchong City and University Cooperation (18SXHZ0492).

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    Authors and Affiliations

    1. Department of Ophthalmology, Affiliated Hospital of North Sichuan Medical College, 1 Mao Yuan South Road, Nanchong, Sichuan, China

      Xuan Liao, Qing-Qing Tan & Chang-Jun Lan

    2. Department of Ophthalmology and Optometry, North Sichuan Medical College, Nanchong, Sichuan, China

      Xuan Liao, Mei-Jie Wang, Qing-Qing Tan & Chang-Jun Lan

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    1. Xuan Liao
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    Contributions

    All authors contributed to the study conception and design. Material preparation, data collection and analysis were performed by X.L and M.J.W. The first draft of the manuscript was written by X.L and M.J.W and all authors commented on previous versions of the manuscript. All authors read and approved the final manuscript.

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    Correspondence to Chang-Jun Lan.

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    All procedures performed in studies involving human participants were in accordance with the ethical standards of the Institutional Review Board of Affiliated Hospital of North Sichuan Medical College and with the 1964 Helsinki declaration and its later amendments or comparable ethical standards.

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    Informed consent was obtained from all individual participants included in the study.

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    Xuan Liao and Mei-Jie Wang contributed equally to this work.

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    Cite this article

    Liao, X., Wang, MJ., Tan, QQ. et al. Repeatability of i.Profiler for measuring wavefront aberrations in healthy eyes. Int Ophthalmol 42, 2525–2531 (2022). https://doi.org/10.1007/s10792-022-02300-x

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    • DOI: https://doi.org/10.1007/s10792-022-02300-x

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