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The association of various obstetric and perinatal factors with retinopathy of prematurity

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Abstract

Purpose

To analyze the effects of various obstetric and perinatal factors on the severity of retinopathy of prematurity (ROP).

Methods

Infants born at ≤ 32 weeks of gestation, with less than 1500 g gestational weight and having at least stage 1 ROP, were reviewed. Group1A included treatment-requiring ROP (TR-ROP), and group 2A included the remaining patients not requiring treatment. Group 1B included stage 3 ROP cases, and group 2B included the remaining stage 2 or 1 ROP cases. Group 1C included cases with zone III disease, and group 2C the remaining. The control group (group C) was composed of premature infants without ROP. The multiple comparisons were made among groups 1A, 2A, and C; 1B, 2B, and C; 1C, 2C, and C.

Results

A total of 311 infants were included. Group 1A included 34 cases, group 1B 60, group 1C 51, and group C 98. Antenatal steroid administration, gestational diabetes mellitus (GDM), gestational weight (GW), gestational age (GA), sepsis, continuous positive airway pressure (CPAP) time, and invasive mechanical ventilation (MV) time were associated with TR-ROP, stage 3 ROP, and zone I, and II disease (p < 0.05). Pregestational diabetes mellitus (DM) was only associated with stage 3 ROP (p = 0.031). Gestational hypertension was only associated with zone I and II disease (p = 0.034). The use of low-molecular-weight heparin may be protective against stage 3 disease (p = 0.031).

Conclusion

Antenatal steroid administration, GDM, GW, GA, sepsis, CPAP time, and invasive MV time were risk factors for TR-ROP and stage 3 ROP, while pregestational DM was only associated with stage 3 ROP.

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All the authors have full control of all primary data and agree to allow the International Ophthalmology to review their data upon request.

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Acknowledgements

The paper is edited for proper language by AJE editors. Certificate Verification Key is 3695-38C9-3424-574F-61DE.

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Authors and Affiliations

  1. Department of Obstetrics and Gynecology, Eskisehir Acibadem Hospital, Eskisehir, Turkey

    Ozlem Ozgur Gursoy, Hulusi Goktug Gurer & Ceren Yildiz Eren

  2. Department of Pediatrics and Neonatology, Eskisehir Acibadem Hospital, Eskisehir, Turkey

    Pinar Erdogan Ozgur

  3. Department of Ophthalmology, Eskisehir Osmangazi University Medical Faculty, Turkey, Eskisehir

    Huseyin Gursoy

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  1. Ozlem Ozgur Gursoy
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All of the authors meet all four of the following conditions: 1. Make substantial contributions to conception and design, and/or acquisition of data, and/or analysis and interpretation of data; 2. Participate in drafting the article or revising it critically for important intellectual content; 3. Give final approval of the version to be submitted; 4. Agreed to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.

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Correspondence to Huseyin Gursoy.

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Ozgur Gursoy, O., Gurer, H.G., Yildiz Eren, C. et al. The association of various obstetric and perinatal factors with retinopathy of prematurity. Int Ophthalmol 42, 2719–2728 (2022). https://doi.org/10.1007/s10792-022-02260-2

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  • DOI: https://doi.org/10.1007/s10792-022-02260-2

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