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The evaluation of patient demographics, etiologies and apraclonidine test results in adult Horner's syndrome

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Abstract

Purpose

We aimed to demonstrate the patient demographics, etiologies and apraclonidine test results in adult Horner's syndrome.

Methods

This retrospective study was performed by the analysis of medical data of patients who were given 0.5% apraclonidine test. Patients' past medical history, demographic data, etiologies, accompanying neurological findings and pharmacological test results were assessed.

Results

Forty patients (21 females and 19 males) with a mean age of 50.3 ± 11.6 years were evaluated. Apraclonidine 0.5% test was positive in 37 patients (92.5%). An etiology could be identified in 20 patients (central [9 patients, 45%], preganglionic [9 patients, 45%] and postganglionic [2 patients, 10%]). Neurological findings accompanying Horner’s syndrome were present in 8 patients.

Conclusion

Despite detailed investigations, in a significant number of patients with Horner's syndrome an underlying cause may not be detected. Among the identifiable lesions, central and preganglionic involvements are still the first leading causes of Horner's syndrome. In addition, apraclonidine test may not be positive in all patients and a negative response does not exclude Horner's syndrome.

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Availability of data and material

All data obtained during the study process were used in the study.

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Acknowledgements

This work was supported by Scientific Research Project Coordination Unit of İzmir Democracy University. Project number:TPF-20H04.

Funding

This work was supported by Scientific Research Project Coordination Unit of İzmir Democracy University. Project number: TPF-20H04.

Author information

Authors and Affiliations

  1. Department of Neurology, Bozyaka Training and Research Hospital, Izmir, Turkey

    Dilek Top Karti

  2. Department of Ophthalmology, İzmir Democracy Univesity, Güzelyalı Konak /İZMİR, Mehmet Ali Akman Mahallesi, 13. Sokak No:2, Izmir, Turkey

    Omer Karti

  3. Department of Neurology, Ege University Medical Faculty, Izmir, Turkey

    Gulsum Saruhan Durmaz, Figen Gokcay & Nese Celebisoy

Authors
  1. Dilek Top Karti
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  2. Omer Karti
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  3. Gulsum Saruhan Durmaz
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  4. Figen Gokcay
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  5. Nese Celebisoy
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Contributions

All co-authors have contributed to the study, and all have read and approved the final version of the manuscript. O.K. and D.T.K had contributed to the concept. O.K., D.T.K., N.C. and F.G. were involved in the designing. F.G., N.C., O.K., D.T.K. and G.S.D participated in data collection or processing, analysis or interpretation, literature search and writing.

Corresponding author

Correspondence to Omer Karti.

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Conflicts of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

Ethics approval

This study was conducted in accordance with the tenets of the Helsinki Declaration after obtaining the approval of local ethics committee.

Human and animal research

There was no research on animals in this manuscript.

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Top Karti, D., Karti, O., Saruhan Durmaz, G. et al. The evaluation of patient demographics, etiologies and apraclonidine test results in adult Horner's syndrome. Int Ophthalmol 42, 1233–1239 (2022). https://doi.org/10.1007/s10792-021-02109-0

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  • DOI: https://doi.org/10.1007/s10792-021-02109-0

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