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Frequency and risk factors of narrow angles in patients with pseudoexfoliation: a case–control study

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Abstract

Purpose

To determine the frequency and risk factors of narrow angles in pseudoexfoliation (PXF) patients.

Methods

A prospective case–control study was conducted during the period from March 2017 to December 2020. Adult patients (above 40 years) presenting with PXF were consecutively enrolled (study group). Cases were matched with individuals above 40 years presenting to a comprehensive ophthalmology clinic without evidence of PXF (control group).

Results

We enrolled 196 PXF patients and 98 controls. The occurrence of narrow angles was 25% in the PXF group and 5.1% in the control group (P = 0.0001). Compared to controls, PXF patients were older (72.6 ± 9.6 vs. 64.4 ± 8.5, P < 0.0001) and had a lower mean ACD (2.79 ± 0.4 vs. 3.05 ± 0.4, P < 0.0001). There was no difference in AL measurements between both groups (23.3 ± 1.4 vs. 23.7 ± 1.0, P = 0.0714). After stratification by age group and gender, the risk of narrow angles was higher in PXF patients above 70 years (OR, 4.15; 95% CI, 0.91–23.87; P, 0.044). There was no gender difference in the risk of developing narrow angles.

Conclusion

Narrow angles are more frequently encountered in PXF patients compared to controls. Advanced age (> 70 years) is significantly associated with an increased likelihood of developing narrow angles.

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Acknowledgements

The authors would like to acknowledge the efforts of Muneera AlFutais, clinical research coordinator, for her assistance with patient enrollment and data collection.

Funding

This work did not receive any form of funding.

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Authors and Affiliations

  1. King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia

    Adi Mohammed Al Owaifeer, Ibrahim AlObaida, Sultan Alzuhairy, Syed J. Raheman, Leyla Aljasim & Deepak P. Edward

  2. Department of Surgery, College of Medicine, Ophthalmology Unit, King Faisal University, 31982, Al-Ahsa, Saudi Arabia

    Adi Mohammed Al Owaifeer

  3. Department of Ophthalmology, College of Medicine, Qassim University, Qassim, Saudi Arabia

    Sultan Alzuhairy

  4. Department of Ophthalmology and Visual Sciences, University of Illinois College of Medicine, Chicago, Chicago, IL, USA

    Deepak P. Edward

Authors
  1. Adi Mohammed Al Owaifeer
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  2. Ibrahim AlObaida
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  3. Sultan Alzuhairy
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  4. Syed J. Raheman
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  5. Leyla Aljasim
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  6. Deepak P. Edward
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Corresponding author

Correspondence to Adi Mohammed Al Owaifeer.

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The authors have no relevant financial or non-financial interests to disclose.

Ethics approval

This study was approved by the Institutional Review Board at King Khaled Eye Specialist Hospital (1542-P).

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Al Owaifeer, A.M., AlObaida, I., Alzuhairy, S. et al. Frequency and risk factors of narrow angles in patients with pseudoexfoliation: a case–control study. Int Ophthalmol 42, 1085–1091 (2022). https://doi.org/10.1007/s10792-021-02094-4

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  • DOI: https://doi.org/10.1007/s10792-021-02094-4

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