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The effect of topical bimatoprost on corneal clarity in primary open-angle glaucoma: a longitudinal prospective assessment

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Abstract

Purpose

To study the effect of topical bimatoprost on the corneal optical density values using a dual Scheimpflug Placido analysis system.

Methods

This longitudinal case–control study included 18 patients with newly diagnosed primary open-angle glaucoma who received topical bimatoprost as a first-line treatment and 20 healthy individuals (age and sex-matched controls). Corneal densitometry data were obtained using the dual Scheimpflug analyzer at pre-treatment and 1st, 6th, 12th, 18th months of post-treatment. Repeated measures of ANOVA and Pearson correlation tests were used for statistical analysis.

Results

There were statistically significant differences between pre-treatment and post-treatment 1st and 6th months corneal densitometry values (p < 0.001, p = 0.007, respectively). However, there was no statistically significant difference between the post-treatment 12th and 18th months (p > 0.05). Corneal densitometry values decreased during the 1st month. Intraocular pressure (IOP) differences were statistically significant between baseline and 1 month after treatment (P < 0.001), however not statistically significant between the 1st and 6th, 6th and 12th, 12th and 18th months after treatment (p > 0.05, for all). Corneal densitometry was not correlated with IOP (r = − 0.037, p = 0.44). In the control group, there was no statistically significant difference between baseline and post-baseline 18th-month corneal densitometry measurements (p > 0.05).

Conclusions

Topical bimatoprost administration might result in a decrease in corneal densitometry measurement. It is of clinical importance that topical bimatoprost administration can affect corneal transparency and cause a possible alteration in corneal properties.

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Authors and Affiliations

  1. University of Health Sciences Dışkapı Yıldırım Beyazıt Training and Research Hospital, Omer Halisdemir Avenue No:20, 06110, Altındag, Ankara, Turkey

    Numan Eraslan & Osman Celikay

  2. University of Health Sciences Ulucanlar Eye Training and Research Hospital, Ankara, Turkey

    Eren Ekici

Authors
  1. Numan Eraslan
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  2. Eren Ekici
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  3. Osman Celikay
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Correspondence to Numan Eraslan.

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All procedures performed in studies involving human participants were in accordance with the ethical standards of the institutional and/or national research committee and with the 1964 Helsinki Declaration and its later amendments or comparable ethical standards.

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Eraslan, N., Ekici, E. & Celikay, O. The effect of topical bimatoprost on corneal clarity in primary open-angle glaucoma: a longitudinal prospective assessment. Int Ophthalmol 42, 731–738 (2022). https://doi.org/10.1007/s10792-021-02035-1

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  • DOI: https://doi.org/10.1007/s10792-021-02035-1

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