Abstract
Purpose
In order to analyze the data and retinal microvasculature for non-arteritic anterior ischemic optic neuropathy (NAION), patients were referred to have carotid Doppler ultrasound (CDU) from 2016 to 2020.
Methods
In this case–control observational study, 30 NAION patients were evaluated with CDU. Twenty-two NAION patients (at least 3 months after the onset of symptoms) and 9 normal subjects underwent a complete ophthalmic examination including optical coherence tomography (OCT) and optical coherence tomography angiography (OCT-A). NAION eyes and fellow eyes were further divided into two groups based on the presence of carotid stenosis (CS). NAION patients with CS were termed “CS-NAION”; and those without CS were termed “NCS-NAION.” Measurements of radial peripapillary capillary vessel density (RPC VD), ganglion cell complex (GCC), retinal nerve fiber layer (RNFL) thicknesses were compared among groups.
Results
Fourteen of 30 NAION patients referred to have carotid Doppler were positive for CS with each one of such referrals having less than 50% stenosis. RNLF, GCC and RPC VDs were reduced in NAION patients’ eyes, when compared to controls and the fellow eyes. RPC VD was significantly lower in the temporal-superior (P = 0.037) and the superior-temporal (P = 0.012) sectors of the NCS-NAION patients than in the CS-NAION patients. No significant differences were found between CS-fellow eyes and NCS-fellow eyes in terms of RPC VDs, RNLF or GCC.
Conclusion
Results of the study highlight the effect of the carotid artery stenosis on ocular perfusion pressure in the pathogenesis of NAION. More extensive studies are necessary.
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References
Gonul S, Koktekir BE, Bakbak B et al (2013) Comparison of the ganglion cell complex and retinal nerve fibre layer measurements using Fourier domain optical coherence tomography to detect ganglion cell loss in non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol 97(8):1045–1050
Aggarwal D, Tan O, Huang D et al (2012) Patterns of ganglion cell complex and nerve fiber layer loss in nonarteritic ischemic optic neuropathy by Fourier-domain optical coherence tomography. Invest Ophthalmol Vis Sci 53(8):4539–4545
Goto K, Miki A, Araki S et al (2016) Time course of macular and peripapillary inner retinal thickness in non-arteritic anterior ischaemic optic neuropathy using spectral-domain optical coherence tomography. Neuroophthalmology 40(2):74–85
Oto S, Yilmaz G, Cakmakci S et al (2002) Indocyanine green and fluorescein angiography in nonarteritic anterior ischemic optic neuropathy. Retina 22:187–191
Arnold AC, Hepler RS (1994) Fluorescein angiography in acute nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol 117:222–230
Rougier MB, Delyfer MN, Korobelnik JF (2017) OCT angiography of acute non-arteritic anterior ischemic optic neuropathy. J Fr Ophtalmol 40:102–109
Sharma S, Ang M, Najjar RP, Sng C, Cheung CY et al (2017) Optical coherence tomography angiography in acute non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol 101:1045–1051
Wright Mayes E, Cole ED, Dang S et al (2017) Optical coherence tomography angiography in nonarteritic anterior ıschemic optic neuropathy. J Neuroophthalmol 37(4):358–364
Liu CH, Wu WC, Sun MH et al (2017) Comparison of the retinal microvascular density between open angle glaucoma and nonarteritic anterior ıschemic optic neuropathy. Invest Ophthalmol Vis Sci 58(9):3350–3356
Hata M, Oishi A, Muraoka Y et al (2017) Structural and functional analyses in nonarteritic anterior ıschemic optic neuropathy: optical coherence tomography angiography study. J Neuroophthalmol 37(2):140–148
Burde RM (1993) Optic disk risk factors for nonarteritic anterior ischemic optic neuropathy. Am J Ophthalmol 116:759–764
Hayreh SS (2000) Ischaemic optic neuropathy. Indian J Ophthalmol 48(3):171–194
Metzler W, Kessler G, Benzer W et al (1990) Ophthalmologische Bedeutung stenosierender Karotisprozesse [Ophthalmological significance of stenosing carotid processes]. Wien Med Wochenschr 140(14):387–389
Leiba H, Rachmiel R, Harris A et al (2000) Optic nerve head blood flow measurements in non-arteritic anterior ischaemic optic neuropathy. Eye (Lond) 14(Pt 6):828–833
Wang Y, Fawzi AA, Varma R et al (2011) Pilot study of optical coherence tomography measurement of retinal blood flow in retinal and optic nerve diseases. Invest Ophthalmol Vis Sci 52:840–845
Gaier ED, Wang M, Gilbert AL et al (2018) Quantitative analysis of optical coherence tomographic angiography (OCT-A) in patients with non-arteritic anterior ischemic optic neuropathy (NAION) corresponds to visual function. PLoS ONE 13(6):e0199793
Higashiyama T, Ichiyama Y, Muraki S et al (2016) Optical coherence tomography angiography in a patient with optic atrophy after non-arteritic anterior ischaemic optic neuropathy. Neuroophthalmology 40(3):146–149
Yu PK, Cringle SJ, Yu DY (2014) Correlation between the radial peripapillary capillaries and the retinal nerve fibre layer in the normal human retina. Exp Eye Res 129:83–92
Razek AA, Elkhamary S (2011) MRI of retinoblastoma. Br J Radiol 84(1005):775–784
Abdel Razek AA, Elkhamary S, Al-Mesfer S, Alkatan HM (2012) Correlation of apparent diffusion coefficient at 3T with prognostic parameters of retinoblastoma. AJNR Am J Neuroradiol 33(5):944–948
Eissa L, Abdel Razek AAK, Helmy E (2021) Arterial spin labeling and diffusion-weighted MR imaging: utility in differentiating idiopathic orbital inflammatory pseudotumor from orbital lymphoma. Clin Imaging 71:63–68
Wolf S, Rebstock J, Bertram B et al (1989) Retinal hemodynamics and morphologic findings in patients with occlusion of the internal carotid artery. Fortschritte der Ophthalmologie: Zeitschrift der Deutschen Ophthalmologischen Gesellschaft 86(4):339–342
Abdel Razek AA, Denewer AT, Hegazy MA, Hafez MT (2014) Role of computed tomography angiography in the diagnosis of vascular stenosis in head and neck microvascular free flap reconstruction. Int J Oral Maxillofac Surg 43(7):811–815
Forjoe T, Asad Rahi M (2019) Systematic review of preoperative carotid duplex ultrasound compared with computed tomography carotid angiography for carotid endarterectomy. Ann R Coll Surg Engl 101(3):141–149
Hayreh SS, Zimmerman MB, Podhajsky P et al (1994) Nocturnal arterial hypotension and its role in optic nerve head and ocular ischemic disorders. Am J Ophthalmol 117:603–624
Arnold AC (2003) Pathogenesis of nonarteritic anterior ischemic optic neuropathy. J Neuroophthalmol 23:157–163
Knox DL, Duke JR (1971) Slowly progressive ischemic optic neuropathy: A clinicopathologic case report. Trans Am Acad Ophthalmol Otolaryngol 75(5):1065–1068
Levin LA, Louhab A (1996) Apoptosis of retinal ganglion cells in anterior ischemic optic neuropathy. Arch Ophthalmol 114(4):488–491
Kaup M, Plange N, Arend KO, Remky A (2006) Retrobulbar haemodynamics in non-arteritic anterior ischaemic optic neuropathy. Br J Ophthalmol 90(11):1350–1353. https://doi.org/10.1136/bjo.2006.093559
Hayreh SS, Zimmerman MB (2017) Ocular arterial occlusive disorders and carotid artery disease. Ophthalmol Retina Jan-Feb 1(1):12–18
Zhu W, Chen T, Jin L et al (2017) Carotid artery intimal medial thickness and carotid artery plaques in hypertensive patients with non-arteritic anterior ischaemic optic neuropathy. Graefes Arch Clin Exp Ophthalmol 255(10):2037–2043
Hayreh SS, Piegors DJ, Heistad DD (1997) Serotonin induced constriction of ocular arteries in atherosclerotic monkeys: Implications for ischemic disorders of retina and optic nerve head. Arch Ophthalmol 115:220–228
Mense L, Reimann M, Rüdiger H et al (2010) Autonomic function and cerebral autoregulation in patients undergoing carotid endarterectomy. Circ J 74:2139–2145
Kitagawa K (2010) Carotid stenosis, baroreceptor sensitivity and cerebral autoregulation – implication for cerebral hyperperfusion syndrome. Circ J 74(10):2058–2059
Acknowledgements
This study was performed in line with the principles of the Declaration of Helsinki. Approval was granted by the Ethics Committee of Istanbul Bakırköy Dr. Sadi Konuk Research and Education Hospital (Date 2020/No 12).
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Kaya, F.S. Carotid disease and retinal optical coherence tomography angiography parameters in patients with non-arteritic anterior ischemic optic neuropathy. Int Ophthalmol 42, 123–131 (2022). https://doi.org/10.1007/s10792-021-02007-5
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DOI: https://doi.org/10.1007/s10792-021-02007-5