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Phacoemulsification versus Phacotrabeculectomy in Medically Controlled Primary Angle Closure Glaucoma with Cataract in an Indian Cohort: A randomized controlled trial

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Abstract

Purpose

To compare the outcomes of phacoemulsification with phacotrabeculectomy in primary angle closure glaucoma (PACG) eyes with medically controlled intraocular pressure (IOP).

Methods

Prospective, randomized control trial including 33 eyes of 33 patients who underwent phacoemulsification (Phaco) and 37 eyes (37 patients) who underwent phacotrabeculectomy (PT). The primary outcome measure was survival defined as IOP control (IOP ≥ 6 and ≤ 21 mmHg without antiglaucoma medications (AGM) at different time points. Secondary outcome measures were the rate of visual recovery and complications.

Results

The mean age in years (PT: 58.5 ± 9.8, Phaco:61.6 ± 8.9; p = 0.16), preoperative mean deviation in decibel (PT: −18.7 ± 9.3; Phaco: −16.6 ± 7.9; p = 0.32) and the mean follow up in years (PT: 2.5 ± 1.8; Phaco: 2.8 ± 2.0; p = 0.63) were similar in the two groups. The mean preoperative AGMs were more in the PT group (PT: 2.13 ± 0.97, Phaco: 1.60 ± 0.78; p = 0.01). In both the groups the survival was similar at all-time points (PT: 78% at 1-year and 52% at 5-years, Phaco: 80% at 1 year and 59% at 5 years (P = 0.82). The postoperative visual acuity in LogMAR was significantly better in the Phaco group at 1 month (PT: 0.22 ± 0.38, Phaco:0.06 ± 0.07; p = 0.02). Postoperative AGM (p = 0.68) and rate of visual field progression PT: −0.46 ± 0.41 dB/year; Phaco: −0.38 ± 0.73 dB/year; p = 0.67) were similar in both groups. One eye in PT group developed malignant glaucoma which resolved with laser hyaloidotomy and cycloplegic therapy.

Conclusions

More rapid visual recovery with similar IOP control and similar visual field stability favor phacoemulsification to phacotrabeculectomy in medically controlled PACG eyes with cataract.

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Funding

Hyderabad Eye Research Foundation.

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Authors and Affiliations

  1. VST Glaucoma Center, L V Prasad Eye Institute, Banjara Hills, Hyderabad, India

    Sirisha Senthil, Nikhil Choudhari & Chandrasekhar Garudadri

  2. Narayana Nethralaya, Bangalore, India

    Harsha L. Rao

  3. University Medical Center, University Eye Clinic Maastricht, Maastricht, The Netherlands

    Harsha L. Rao

  4. Kallam Anji Reddy Campus, L.V Prasad Eye Institute, L V Prasad Marg, Road No: 2, Banjara Hills, Hyderabad, 500034, India

    Sirisha Senthil, Nikhil Choudhari & Chandrasekhar Garudadri

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  1. Sirisha Senthil
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  3. Nikhil Choudhari
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  4. Chandrasekhar Garudadri
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Contributions

Conceptualization: SS contributed to the conceptualization of the article, methodology: HLR, GCS, NKL and SS contributed to the design of the article, Statistical analysis: HLR, SS contributed to the statistical analysis of the article, original draft preparation: SS contributed to the preparation and writing of the draft, review and editing: SS, HLR, NKL, GCS contributed to the reviewing and editing of the draft.

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Correspondence to Sirisha Senthil.

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Senthil, S., Rao, H.L., Choudhari, N. et al. Phacoemulsification versus Phacotrabeculectomy in Medically Controlled Primary Angle Closure Glaucoma with Cataract in an Indian Cohort: A randomized controlled trial. Int Ophthalmol 42, 35–45 (2022). https://doi.org/10.1007/s10792-021-01997-6

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  • DOI: https://doi.org/10.1007/s10792-021-01997-6

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