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Systemic oxidative stress biomarkers in patients with vitreomacular traction syndrome

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Abstract

Purpose

To evaluate whether the systemic oxidative stress biomarkers increased in patients with vitreomacular traction syndrome (VMT).

Methods

This study compared 25 patients diagnosed with VMT with 20 healthy controls. As a biomarker of systemic oxidative stress, malondialdehyde (MDA) was measured. Total oxidant status (TOS) and total antioxidant status (TAS) were measured to evaluate the systemic oxidant status.

Results

Serum MDA values were significantly higher among the patients (p < 0.001). The ideal cut-off value for MDA was determined to be 22.1 µmol/L, with 80% sensitivity and 75% specificity. The between-group differences were not statistically significant for TOS or TAS (p = 0.326 and p = 0.698, respectively).

Conclusion

Increased MDA levels suggest that systemic oxidative stress may play a role in VMT.

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Data availability

Data will be shared upon request.

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Funding

Health Science University, Kayseri City Training and Research Hospital, Foundation of Scientific Research Support funded this study (2019–22).

Author information

Authors and Affiliations

  1. Department of Ophthalmology, Kayseri City Training and Research Hospital, Health Science University, Yakut Region, 3844 Street, House Number: 20/16, 38001, Kayseri, Turkey

    Deniz Kilic, Ender Sırakaya, Bekir Küçük, Esra Vural, Soner Guven & Necati Duru

  2. Department of Biochemistry, Kayseri City Training and Research Hospital, Health Science University, Kayseri, Turkey

    Derya Kocer

Authors
  1. Deniz Kilic
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  2. Derya Kocer
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  3. Ender Sırakaya
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  4. Bekir Küçük
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  5. Esra Vural
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  6. Soner Guven
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  7. Necati Duru
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Contributions

D.K and D.K conceived the study and its design, acquired the data, drafted the article, critically revised the paper for important intellectual content, and obtained funding. ES, BK and EV conceived the study and its design; acquired and interpreted the data; and critically revised the manuscript for important intellectual content. SG and ND contributed to collection of data; statistical analysis; obtained funding; provided administrative, technical, or material support; and supervised the whole course of the study. All authors read and approved the final manuscript.

Corresponding author

Correspondence to Deniz Kilic.

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Conflict of interest

The authors report no conflict of interest.

Consent to participate and Ethical disclosure

The Research Ethics Committee of Erciyes University approved the study (2019/769), and the tenets of the Declaration of Helsinki were strictly followed. After being notified about the purpose and possible consequences of the study, each patient signed an informed consent document.

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Informed consent was taken from individuals.

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Kilic, D., Kocer, D., Sırakaya, E. et al. Systemic oxidative stress biomarkers in patients with vitreomacular traction syndrome. Int Ophthalmol 41, 3789–3796 (2021). https://doi.org/10.1007/s10792-021-01949-0

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  • DOI: https://doi.org/10.1007/s10792-021-01949-0

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