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Ocular manifestations of HLA B 27 associated uveitis: a study of 255 cases from a tertiary eye care centre from South India

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Abstract

Purpose

To describe the clinical profile of HLA B-27-associated uveitis in Indian population.

Method

We conducted a retrospective review of medical records of 431 eyes of 255 consecutive patients with HLA B-27-associated uveitis, presented to our institute between 2012 and 2017.

Result

The study observed a male preponderance (75.7%) and the mean age of patients was 35.6 ± 13.3 years. A total of 412 (95.3%) eyes had anterior uveitis, 17(3.9%) eyes had anterior and intermediate uveitis and 3 eyes (0.7%) had intermediate uveitis. Retinal vasculitis was detected in four eyes (0.9%). A total of 176 patients (69%) in the study had evidence of systemic disease and 85% patients developed recurrences. In addition to the treatment with topical and oral steroid, immunosuppressive was required in 39.6% patients and 4% patients received biological therapy. The majority of the eyes (78.4%) had a good visual outcome, while 61 (14.2%) eyes had moderate visual impairment and 32 (7.4%) eyes had severe visual impairment at the time of final follow-up.

Conclusion

HLA-B27-associated uveitis can be associated with higher number of posterior segment involvement than it is estimated and aggressive therapy in moderate-to-severe uveitis can prevent severe visual impairment in these patients.

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Authors and Affiliations

  1. Medical and Vision Research Foundations, Sankara Nethralaya, 18, College Road, Sankara Nethralaya, Chennai, 600 006, Tamil Nadu, India

    Ruchika Lakra & Parthopratim Dutta Majumder

  2. Department of Uvea, Medical and Vision Research Foundations, Sankara Nethralaya, 18, College Road, Sankara Nethralaya, Chennai, 600 006, Tamil Nadu, India

    Nandhini Elango, Amala Elizabeth George, Sudha K. Ganesh, Jyotirmay Biswas & Parthopratim Dutta Majumder

Authors
  1. Ruchika Lakra
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  2. Nandhini Elango
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  3. Amala Elizabeth George
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  4. Sudha K. Ganesh
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  5. Jyotirmay Biswas
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  6. Parthopratim Dutta Majumder
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Correspondence to Parthopratim Dutta Majumder.

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The authors declare no financial interest or sources of support. This paper has never been submitted to any journal nor published in any form of media before. There is no conflict of interest.

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Lakra, R., Elango, N., George, A.E. et al. Ocular manifestations of HLA B 27 associated uveitis: a study of 255 cases from a tertiary eye care centre from South India. Int Ophthalmol 41, 3743–3748 (2021). https://doi.org/10.1007/s10792-021-01943-6

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  • DOI: https://doi.org/10.1007/s10792-021-01943-6

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