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Comparison of efficacy of trehalose-based eye drops versus topical 0.1% Hyaluronic Acid for management of clinically significant dry eye using non-invasive investigational modalities

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Abstract

Purpose

To compare the efficacy of trehalose-HA eye drops versus 0.1% hyaluronic acid for the treatment of dry eye.

Methods

This prospective, comparative, contralateral eye study included sixty eligible patients (mean age 44.13 ± 14.53 years). Patients having a SPEED questionnaire score of 16 or above, objective scatter index (OSI) > 1 and non-invasive tear break up time (NIBUT) of 10 s or less were included in the study. Eyes were randomized to receive 0.1% hyaluronic acid (HA) in one eye and trehalose-HA eye drops in the contralateral eye. At baseline, 1- and 3-month follow-ups, OSI, NIBUT, MG loss, tear meniscus height (TMH) and tear film osmolarity (TFO) were evaluated using non-invasive modalities

Results

There was a statistically significant improvement in NIBUT, TMH, OSI, SPEED questionnaire score in the trehalose-HA compared to the 0.1% HA group at both 1- and 3-month visits (p < 0.05). In both the study groups, compared to the baseline, the mean values of TFO, MG loss, OSI and SPEED questionnaire score significantly reduced at 3 months (p < 0.05). The mean values of NIBUT and tear meniscus height on the other hand showed a significant increase compared to the baseline values (p < 0.05). Both drugs were well tolerated by the study participants without any significant ocular side effects.

Conclusion

Trehalose-HA was found to be more effective than 0.1% HA eye drops in the management of symptomatic dry eye, as shown by significant reduction in NIBUT, TMH and OSI, when evaluated using non-invasive modalities of dry eye evaluation

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Authors and Affiliations

  1. Nethradhama Super Speciality Eye Hospital, 256/14, Kanakapura Road, Opp ICICI Bank, 7th Block, Jayanagar, Bengaluru, Karnataka, 560070, India

    Sheetal Brar, Hemanth Reddy Vanga & Sri Ganesh

Authors
  1. Sheetal Brar
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  2. Hemanth Reddy Vanga
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  3. Sri Ganesh
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Contributions

SB—Data analysis, Manuscript writing, Review of literature, HRV—Data collection, Review of literature, SG—Concept and Design, Critical revision of manuscript.

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Correspondence to Sheetal Brar.

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Brar, S., Vanga, H.R. & Ganesh, S. Comparison of efficacy of trehalose-based eye drops versus topical 0.1% Hyaluronic Acid for management of clinically significant dry eye using non-invasive investigational modalities. Int Ophthalmol 41, 3349–3359 (2021). https://doi.org/10.1007/s10792-021-01897-9

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