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Combined Ab interno viscocanaloplasty (ABiC) in open-angle glaucoma: 12-month outcomes

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Abstract

Purpose

The aim of this study was to analyse the safety profile and efficacy of ab interno viscocanaloplasty (ABiC) through to 12 months post-operatively.

Methods

In this retrospective study, the medical records of all patients who underwent ABiC between September 2015 and December 2019 were analysed. Complete success was defined as a 12-month reduction in intraocular pressure (IOP) ≥ 20% from baseline with no concomitant medications. Qualified success criteria were identical, with no more medications than at baseline.

Results

In all, 54 eyes of 41 patients were analysed. Mean IOP decreased from 23.6 ± 7.4 mmHg preoperatively to 14.2 ± 2.9 mmHg (-39.8%; p < 0.001) after 12 months. Concomitantly, the number of anti-glaucoma treatment dropped from 2.9 ± 1.0 to 0.6 ± 1.1 (-79.3%; p < 0.001). Amongst patients with a baseline MD < -12.0 dBs, mean IOP decreased from 22.8 ± 9.8 mmHg to 13.8 ± 4.4 mmHg (p = 0.049), with a concomitant reduction of medications from 2.8 ± 1.3 to 1.2 ± 1.3 (p < 0.001). Complete success at 12 months was achieved in 46% of eyes, and qualified success was achieved in 65% of eyes. Amongst eyes with a baseline MD < -12.0 dBs, 50% achieved complete success, and 83.3% achieved qualified success. A total of 19 eyes (35.2%) were considered surgical failure, all due to uncontrolled IOP. Of them, 7 eyes (13.0%) required further filtering surgery. Twelve post-operative adverse events were observed, with early post-operative IOP spikes being the most common (22.2%).

Conclusions

ABIC achieved a statistically significant reduction in IOP and anti-glaucoma medications through 12 months, while maintaining a favourable safety profile in mild-to-severe open-angle glaucoma.

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Data availability

Data are available from the corresponding author upon reasonable request.

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Funding

No external funding was received for this work.

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Authors and Affiliations

  1. Ophthalmology Network Organisation, Clinique de L’Oeil SA, Avenue Bois-de-la-Chapelle 35, 1213, Onex, Geneva, Switzerland

    Kevin Gillmann, Laëtitia Jessy Niegowski & Jean-Marc Baumgartner

  2. Research Institute of Ophthalmology, Giza, Egypt

    Amr Aref

Authors
  1. Kevin Gillmann
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  2. Amr Aref
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  3. Laëtitia Jessy Niegowski
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  4. Jean-Marc Baumgartner
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Contributions

Gillmann K has contributed to design, analysis, graphics, writing and supervision, Aref A and Niegowski LJ collected the data, and Baumgartner JM was involved in design, surgery, treating ophthalmologist, analysis and review.

Corresponding author

Correspondence to Kevin Gillmann.

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Conflicts of interest

None of the co-authors have any relationship with any of the companies or products discussed in this study and therefore have no conflict of interest to declare.

Ethics approval

This retrospective study was ethically validated.

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Informed consent was obtained from all participants.

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Consent for publication was obtained from all participants as part of the informed consent.

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Gillmann, K., Aref, A., Niegowski, L.J. et al. Combined Ab interno viscocanaloplasty (ABiC) in open-angle glaucoma: 12-month outcomes. Int Ophthalmol 41, 3295–3301 (2021). https://doi.org/10.1007/s10792-021-01891-1

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  • DOI: https://doi.org/10.1007/s10792-021-01891-1

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