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Optic nerve sheath fenestration in leukemic patients having increased intracranial pressure: a prospective clinical trial

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Abstract

Purpose

This study aimed to assess the safety and efficacy of optic nerve sheath fenestration (ONSF) in leukemic children having increased intracranial pressure with severe uncontrolled visual loss on medical treatment and not eligible for venous sinus stenting.

Methods

In this non-randomized clinical trial, we included patients presenting with severe sight-threatening papilledema due to increased intracranial pressure following leukemia treatment. All included patients were subjected to a complete history taking, assessment of the visual acuity and fundus examination with fundus photography and grading of papilledema using Frisen scale. Patients were evaluated at 2 weeks and 3 months postoperative by recording the best-corrected visual acuity, assessment of the pupillary reaction and fundus examination and fundus photography with grading of papilledema.

Results

Among 20 patients included in this study, there was a statistically significant improvement in visual acuity of both eyes in all patients. The mean postoperative visual acuity was 0.28 ± 0.10 two weeks after surgery in the right eye and it was 0.42 ± 0.16 in the left eye. The mean visual acuity in the right eye three months after surgery was 0.78 ± 0.19 and it was 0.87 ± 0.17 in the left eye. Three months postoperatively, papilledema resolved completely in both eyes. There were no recorded ocular complications.

Conclusion

In this study, ONSF was sight-saving procedure in all leukemic patients with a significant improvement in the visual acuity, stabilization of the visual function and resolving of the papilledema over follow-up period. There were no recorded intraoperative or postoperative complications. Further well-designed studies are needed to assert upon these results.

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Availability of data and material

Data are available upon request from the corresponding author.

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Authors and Affiliations

  1. Ophthalmology Department, Faculty of Medicine, Alexandria University, Alexandria, Egypt

    Mai A. Mohammed & Ibrahim Y. Allam

  2. Faculty of Medicine, El-Khartoum Square, El Azareeta Medical Campus, Alexandria University, Champollion Street, Alexandria, 21131, Egypt

    Mohamed Fahmy Doheim

Authors
  1. Mai A. Mohammed
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  2. Mohamed Fahmy Doheim
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  3. Ibrahim Y. Allam
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Contributions

MAE, IYA and MFD designed, conducted the study, collected the data, analyzed the data, interpreted the data, wrote and gave their final approval of the manuscript.

Corresponding author

Correspondence to Mohamed Fahmy Doheim.

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Consent to Participate

Informed written consent was obtained from the parents/legal guardians of the study participants before enrollment.

Consent to Publish

Informed written consent was obtained from the parents/legal guardians of the study participants to publish the findings.

Clinical Trials Registration

NCT04431882 (June 2020).

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Mohammed, M.A., Doheim, M.F. & Allam, I.Y. Optic nerve sheath fenestration in leukemic patients having increased intracranial pressure: a prospective clinical trial. Int Ophthalmol 41, 3261–3268 (2021). https://doi.org/10.1007/s10792-021-01887-x

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  • DOI: https://doi.org/10.1007/s10792-021-01887-x

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