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Evaluation of morphological characteristics of diabetic macular edema in patients with non-proliferative versus proliferative diabetic retinopathy: a spectral-domain optical coherence tomography study

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Abstract

Purpose

To evaluate the morphological characteristics in patients with diabetic macular edema (DME), either with co-existent non-proliferative diabetic retinopathy (NPDR) or with PDR.

Methods

Retrospective study includes 138 treatment naïve patients with DME, either with NPDR (n = 96) or in combination with PDR (n = 42). All patients underwent best corrected visual acuity (BCVA) measurement, spectral domain-optical coherence tomography (SD-OCT) and fluorescein angiography, while demographic characteristics were also recorded. Specific clinical and morphological characteristics were analyzed and compared between the two groups.

Results

Patients with DME and PDR presented higher central retinal thickness and mixed type of edema, with predominantly cystoid component and large cysts, extending in the foveal, peri- and para-foveal area, compared to patients with DME and NPDR. The presence of non-perfusion areas in patients with DME and PDR led to additional ellipsoid zone and external limiting membrane disruption in a higher percentage, accompanied with worse visual acuity compared to patients with DME and NPDR. Patients with DME and PDR had also higher vitreomacular traction percentage and higher HbA1c levels than those with DME and NPDR.

Conclusion

Variations in morphological characteristics of DME on SD-OCT existed between patients with NPDR and those with PDR. These differences may explain the alterations in visual acuity and prognosis.

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Data availability

Data are available upon request.

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Funding

No funding was received for this research.

Author information

Authors and Affiliations

  1. 2nd Department of Ophthalmology, National and Kapodistrian University of Athens, Athens, Greece

    George Theodossiadis, Eleni Dimitriou & Panagiotis Theodossiadis

  2. Attikon University Hospital, 1, Rimini street, 12462, Haidari, Greece

    Irini Chatziralli

Authors
  1. Irini Chatziralli
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  2. George Theodossiadis
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  3. Eleni Dimitriou
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  4. Panagiotis Theodossiadis
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Contributions

Irini Chatziralli designed the study, collected data, analyzed data, interpreted data and drafted the manuscript; George Theodossiadis conceived the study, interpreted data and critically revised the manuscript; Eleni Dimitriou collected data; Panagiotis Theodossiadis supervised the study. All authors have read and approved the current version of the manuscript.

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Correspondence to Irini Chatziralli.

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All authors certify that they have no affiliations with or involvement in any organization or entity with any financial interest (such as honoraria, educational grants, or other equity interest), or non-financial interest (such as personal or professional relationships, affiliations, knowledge or beliefs) in the subject matter or materials discussed in this manuscript.

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Chatziralli, I., Theodossiadis, G., Dimitriou, E. et al. Evaluation of morphological characteristics of diabetic macular edema in patients with non-proliferative versus proliferative diabetic retinopathy: a spectral-domain optical coherence tomography study. Int Ophthalmol 41, 2417–2424 (2021). https://doi.org/10.1007/s10792-021-01796-z

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  • DOI: https://doi.org/10.1007/s10792-021-01796-z

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