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Peripapillary vessel density in pediatric cases with buried optic disk drusen

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Abstract

Background

To evaluate the retinal nerve fiber layer (RNFL) and peripapillary vascular density (VD) changes in the pediatric group with optic disk drusen (ODD).

Methods

Sixty eyes of 30 patients with buried ODD referred by the pediatric or neurology physicians to ophthalmology clinic with a preliminary diagnosis of papillary edema were included in this retrospective study. Sixty eyes of 30 healthy children were included as the control group. Thickness of RNFL (micrometer) and VD percentages (%) of the superior, inferior, nasal, and temporal quadrants of the peripapillary region of all cases were evaluated with optical coherence tomography angiography (OCT-A) device.

Results

The study and control groups were homogeneous in terms of age and gender. VD values were significantly lower in the study group for all four quadrants, when compared to controls (p < 0.001, p < 0.001, p = 0.003, and p < 0.001, for inferior, superior, nasal, and temporal quadrants, respectively. For RFNL thickness measurements, a significant difference between groups was only evident for the nasal quadrant, where the study group had significantly higher nasal RFNL thickness (p = 0.001).

Conclusion

This study detected decreases in peripapillary VD values in all quadrants and peripapillary RNFL thickening in nasal quadrant in pediatric cases with buried drusen compared to healthy controls. Further studies are necessary to reveal the effects of drusen pathogenesis on optic nerve head perfusion and to understand the underlying mechanisms of related complications.

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Funding

This research received no specific grant from any funding agency in the public, commercial, or not-for-profit sectors.

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Authors and Affiliations

  1. Department of Ophthalmology, University of Health Sciences, Sisli Hamidiye Etfal Training and Research Hospital, Halaskargazi Avenue, Etfal Street 34371, Şişli, Istanbul, Turkey

    Ibrahim Çağrı Türker, Ceylan Uslu Doğan, Saniye Üke Uzun & Dilek Güven

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  1. Ibrahim Çağrı Türker
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  2. Ceylan Uslu Doğan
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  3. Saniye Üke Uzun
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  4. Dilek Güven
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All the authors contributed to the conception or design of the work, the acquisition, analysis and interpretation of data, drafting the work, revising it critically for important intellectual content and gave final approval of the version to be published.

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Correspondence to Ibrahim Çağrı Türker.

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Türker, I.Ç., Doğan, C.U., Uzun, S.Ü. et al. Peripapillary vessel density in pediatric cases with buried optic disk drusen. Int Ophthalmol 41, 1337–1345 (2021). https://doi.org/10.1007/s10792-021-01700-9

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  • DOI: https://doi.org/10.1007/s10792-021-01700-9

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