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Effects of glaucoma and central corneal thickness on optic nerve head biomechanics

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Abstract

Purpose

To evaluate effects of glaucoma and central corneal thickness (CCT) on optic nerve head biomechanics.

Methods

Four groups were formed according to CCT measurements and the presence of glaucoma. Glaucomatous patients with thin (< 510 µ) and thick (> 570 µ) corneas composed groups 1 and 3, respectively. Nonglaucomatous patients with thin and thick corneas composed groups 2 and 4, respectively. Real-time elastography (RTE) was performed on all groups, and optic nerve strain rate (ONSR), orbital fat strain rate (OFSR), and strain ratio of orbital fat to the optic nerve and medial and lateral parts of the optic nerve (SROFON, SROFMON, SROFLON, respectively) were obtained and compared between groups. The correlations between CCT and these parameters were also investigated.

Results

Statistically significant difference was not found between groups in terms of strain rate of optic nerve and orbital fat, SRFON, SROFMON and SROFLON. There was a positive correlation between ONSR and OFSR and mean CCT in patients with CCT thinner than 510 µ (p: 0.03 r: 0.26, p: 0.01 r: 0.32 respectively).

Conclusion

SROFON, SROFLON and SROFMON values did not differ between glaucomatous and nonglaucomatous patients with thin or thick CCTs. The correlations between CCT and OFSR and ONSR were found to be statistically significant in patients with thin CCT.

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Funding

This study was not funded by any company.

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Authors and Affiliations

  1. Department of Ophthalmology, Sakarya University Medical Education and Research Hospital, Sakarya, Turkey

    Nilgün Özkan Aksoy, Burçin Çakır, Yakup Ersel Aksoy, Kadriye Demir Boncukçu, Sedat Özmen, Erkan Çelik & Gürsoy Alagöz

Authors
  1. Nilgün Özkan Aksoy
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  2. Burçin Çakır
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  3. Yakup Ersel Aksoy
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  4. Kadriye Demir Boncukçu
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  5. Sedat Özmen
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  6. Erkan Çelik
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  7. Gürsoy Alagöz
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Correspondence to Nilgün Özkan Aksoy.

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All authors declare that they have no conflict of interest.

Ethical approval

Prior ethical approval from the Sakarya University Institutional Review Board (IRB: 16214662/050.01.04/34) was taken. The study was performed in adherence to the 1964 Declaration of Helsinki.

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Written informed consent was obtained from each subject or from the parents of each subject in the study.

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Patients or parents of patients signed informed consent regarding publishing their data.

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Özkan Aksoy, N., Çakır, B., Aksoy, Y.E. et al. Effects of glaucoma and central corneal thickness on optic nerve head biomechanics. Int Ophthalmol 41, 1283–1289 (2021). https://doi.org/10.1007/s10792-020-01686-w

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  • DOI: https://doi.org/10.1007/s10792-020-01686-w

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